1921
Volume 90, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Hepatitis E virus (HEV) infections lead to tens of thousands of deaths annually, mostly in developing countries. Hepatitis E poses a significant threat to the health of expectant mothers, a well-noted epidemiologic feature of the disease, but the contribution of vertically transmitted HEV infection to fetal and neonatal morbidity and mortality has received limited attention. Evidence assembled to date suggests that mother-to-child HEV transmission may be frequent and deleterious to the fetus and newborn in pregnancies affected by hepatitis E. Additional work is required to resolve key questions. (1) What risks do subclinical maternal HEV infections and infections early in pregnancy pose to fetal health and development? (2) Does vertical transmission occur during labor and/or breastfeeding and contribute appreciably to neonatal morbidity and mortality? (3) How do treatment decisions for severely ill mothers affect fetal and neonatal outcomes? (4) Can maternal vaccination effectively prevent vertical transmission of HEV?

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2017-06-28
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References

  1. Labrique AB, Kuniholm MH, Nelson KE, Scheld WM, Grayson ML, Hughes JM, , 2010. The global impact of hepatitis E: new horizons for an emerging virus. , eds. Emerging Infections, Vol. 9. Washington, DC: ASM Press, pp 5388.
  2. Rein DB, Stevens G, Theaker J, Wittenborn JS, Wiersma ST, , 2012. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55: 988997.[Crossref]
  3. Teshale EH, Hu DJ, Holmberg SD, , 2010. The two faces of hepatitis E virus. Clin Infect Dis 51: 328334.[Crossref]
  4. Meng XJ, , 2011. From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety. Virus Res 161: 2330.[Crossref]
  5. Teo CG, , 2010. Much meat, much malady: changing perceptions of the epidemiology of hepatitis E. Clin Microbiol Infect 16: 2432.[Crossref]
  6. Kuniholm MH, Purcell RH, McQuillan GM, Engle RE, Wasley A, Nelson KE, , 2009. Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988–1994. J Infect Dis 200: 4856.[Crossref]
  7. Colson P, Borentain P, Queyriaux B, Kaba M, Moal V, Gallian P, Heyries L, Raoult D, Gérolami R, , 2010. Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis 202: 825834.[Crossref]
  8. Dalton HR, Bendall R, Ijaz S, Banks M, , 2008. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis 8: 698709.[Crossref]
  9. Nelson KE, Kmush B, Labrique AB, , 2011. The epidemiology of hepatitis E virus infections in developed countries and among immunocompromised patients. Expert Rev Anti Infect Ther 9: 11331148.[Crossref]
  10. Matsubayashi K, Kang JH, Sakata H, Takahashi K, Shindo M, Kato M, Sato S, Kato T, Nishimori H, Tsuji K, Maguchi H, Yoshida J, Maekubo H, Mishiro S, Ikeda H, , 2008. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion 48: 13681375.[Crossref]
  11. Pischke S, Suneetha PV, Baechlein C, Barg-Hock H, Heim A, Kamar N, Schlue J, Strassburg CP, Lehner F, Raupach R, Bremer B, Magerstedt P, Cornberg M, Seehusen F, Baumgaertner W, Klempnauer J, Izopet J, Manns MP, Grummer B, Wedemeyer H, , 2010. Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients. Liver Transpl 16: 7482.[Crossref]
  12. Sakata H, Matsubayashi K, Takeda H, Sato S, Kato T, Hino S, Tadokoro K, Ikeda H, , 2008. A nationwide survey for hepatitis E virus prevalence in Japanese blood donors with elevated alanine aminotransferase. Transfusion 48: 25682576.[Crossref]
  13. Takahashi M, Nishizawa T, Yoshikawa A, Sato S, Isoda N, Ido K, Sugano K, Okamoto H, , 2002. Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad. J Gen Virol 83: 19311940.[Crossref]
  14. Xia H, Wahlberg N, Belak S, Meng XJ, Liu L, , 2011. The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective. Arch Virol 156: 121124.[Crossref]
  15. Teo CG, , 2012. Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E. Epidemiol Infect 140: 767787.[Crossref]
  16. Naidu SS, Viswanathan R, , 1957. Infectious hepatitis in pregnancy during Delhi epidemic. Indian J Med Res 45 (Suppl): 7176.
  17. Viswanathan R, , 1957. Certain epidemiological features of infectious hepatitis during the Delhi epidemic, 1955–1956. Hepatitis Frontiers (Henry Ford Hospital International Symposium). Detroit, MI: Churchill, 207210.
  18. Khuroo MS, Teli MR, Skidmore S, Sofi MA, Khuroo MI, , 1981. Incidence and severity of viral hepatitis in pregnancy. Am J Med 70: 252255.[Crossref]
  19. Khatun F, Rasheed S, Moran AC, Alam AM, Shomik MS, Sultana M, Choudhury N, Iqbal M, Bhuiya A, , 2012. Causes of neonatal and maternal deaths in Dhaka slums: implications for service delivery. BMC Public Health 12: 84.[Crossref]
  20. Boccia D, Guthmann JP, Klovstad H, Hamid N, Tatay M, Ciglenecki I, Nizou JY, Nicand E, Guerin PJ, , 2006. High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan. Clin Infect Dis 42: 16791684.[Crossref]
  21. Rab MA, Bile MK, Mubarik MM, Asghar H, Sami Z, Siddiqi S, Dil AS, Barzgar MA, Chaudhry MA, Burney MI, , 1997. Water-borne hepatitis E virus epidemic in Islamabad, Pakistan: a common source outbreak traced to the malfunction of a modern water treatment plant. Am J Trop Med Hyg 57: 151157.
  22. Labrique AB, Sikder SS, Krain LJ, West KP, Jr Christian P, Rashid M, Nelson KE, , 2012. Hepatitis E, a vaccine-preventable cause of maternal death. Emerg Infect Dis 18: 14011404.[Crossref]
  23. Khuroo MS, Duermeyer W, Zargar SA, Ahanger MA, Shah MA, , 1983. Acute sporadic non-A, non-B hepatitis in India. Am J Epidemiol 118: 360364.[Crossref]
  24. Khuroo MS, Kamili S, , 2003. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. J Viral Hepat 10: 6169.[Crossref]
  25. Kumar S, Ratho RK, Chawla YK, Chakraborti A, , 2007. The incidence of sporadic viral hepatitis in North India: a preliminary study. Hepatobiliary Pancreat Dis Int 6: 596599.
  26. Gurley ES, Halder AK, Streatfield PK, Sazzad HM, Nurul Huda TM, Hossain MJ, Luby SP, , 2012. Estimating the burden of maternal and neonatal deaths associated with jaundice in Bangladesh: possible role of hepatitis E infection. Am J Public Health 102: 22482254.[Crossref]
  27. Purcell RH, Ticehurst J, Zuckerman AJ, , 1988. Enterically transmitted non-A, non-B hepatitis: epidemiology and clinical characteristics. , ed. Viral Hepatitis and Liver Disease. New York, NY: Alan R. Liss, 131137.
  28. Wong DC, Purcell RH, Sreenivasan MA, Prasad SR, Pavri KM, , 1980. Epidemic and endemic hepatitis in India: evidence for a non-A, non-B hepatitis virus aetiology. Lancet 2: 876879.[Crossref]
  29. Arankalle VA, Chadha MS, Tsarev SA, Emerson SU, Risbud AR, Banerjee K, Purcell RH, , 1994. Seroepidemiology of water-borne hepatitis in India and evidence for a third enterically-transmitted hepatitis agent. Proc Natl Acad Sci USA 91: 34283432.[Crossref]
  30. Purdy MA, Khudyakov YE, , 2010. Evolutionary history and population dynamics of hepatitis E virus. PLoS One 5: e14376.[Crossref]
  31. Purdy MA, Khudyakov YE, , 2011. The molecular epidemiology of hepatitis E virus infection. Virus Res 161: 3139.[Crossref]
  32. Balayan MS, Andjaparidze AG, Savinskaya SS, Ketiladze ES, Braginsky DM, Savinov AP, Poleschuk VF, , 1983. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20: 2331.[Crossref]
  33. Patra S, Kumar A, Trivedi SS, Puri M, Sarin SK, , 2007. Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection. Ann Intern Med 147: 2833.[Crossref]
  34. Beniwal M, Kumar A, Kar P, Jilani N, Sharma JB, , 2003. Prevalence and severity of acute viral hepatitis and fulminant hepatitis during pregnancy: a prospective study from north India. Indian J Med Microbiol 21: 184185.
  35. Tsega E, Hansson BG, Krawczynski K, Nordenfelt E, , 1992. Acute sporadic viral hepatitis in Ethiopia: causes, risk factors, and effects on pregnancy. Clin Infect Dis 14: 961965.[Crossref]
  36. Goumba CM, Yandoko-Nakoune ER, Komas NP, , 2010. A fatal case of acute hepatitis E among pregnant women, Central African Republic. BMC Res Notes 3: 103.[Crossref]
  37. International Centre for Diarrhoeal Disease Research Bangladesh, 2009. Outbreak of hepatitis E in a low income urban community in Bangladesh. ICDDR, B Health Sci Bull 7: 1420.
  38. Rasheeda CA, Navaneethan U, Jayanthi V, , 2008. Liver disease in pregnancy and its influence on maternal and fetal mortality: a prospective study from Chennai, Southern India. Eur J Gastroenterol Hepatol 20: 362364.[Crossref]
  39. Rayis DA, Jumaa AM, Gasim GI, Karsany MS, Adam I, , 2013. An outbreak of hepatitis E and high maternal mortality at Port Sudan, Eastern Sudan. Pathog Glob Health 107: 6668.[Crossref]
  40. Maila HT, Bowyer SM, Swanepoel R, , 2004. Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995. J Gen Virol 85: 8995.[Crossref]
  41. Goldenberg RL, Thompson C, , 2003. The infectious origins of stillbirth. Am J Obstet Gynecol 189: 861873.[Crossref]
  42. Goldenberg RL, McClure EM, Saleem S, Reddy UM, , 2010. Infection-related stillbirths. Lancet 375: 14821490.[Crossref]
  43. Kelley M, Rubens CE, Group GR, , 2010. Global report on preterm birth and stillbirth (6 of 7): ethical considerations. BMC Pregnancy Childbirth 10 (Suppl 1): S6.[Crossref]
  44. Lawn JE, Blencowe H, Pattinson R, Cousens S, Kumar R, Ibiebele I, Gardosi J, Day LT, Stanton C, Lancet's Stillbirths Series Steering Committee; , 2011. Stillbirths: where? when? why? How to make the data count? Lancet 377: 14481463.[Crossref]
  45. Zhai Q, Zhang LF, Liang RM, Zhang YH, Sun SY, Cao XY, , 1994. Immunohistochemical study of hepatitis E virus antigen in liver tissues from patients with hepatitis E. Chin Med J (Engl) 107: 222224.
  46. El-Esnawy NA, Ali MA, Bayoumi FS, Abo-El-Khir A, Abdel-Wahab KS, , 2001. Waterborne viruses associated with repeated abortion. J Egypt Public Health Assoc 76: 487503.
  47. Tsarev SA, Tsareva TS, Emerson SU, Rippy MK, Zack P, Shapiro M, Purcell RH, , 1995. Experimental hepatitis E in pregnant rhesus monkeys: failure to transmit hepatitis E virus (HEV) to offspring and evidence of naturally acquired antibodies to HEV. J Infect Dis 172: 3137.[Crossref]
  48. Arankalle VA, Chadha MS, Banerjee K, Srinivasan MA, Chobe LP, , 1993. Hepatitis E virus infection in pregnant rhesus monkeys. Indian J Med Res 97: 48.
  49. Kasorndorkbua C, Thacker BJ, Halbur PG, Guenette DK, Buitenwerf RM, Royer RL, Meng XJ, , 2003. Experimental infection of pregnant gilts with swine hepatitis E virus. Can J Vet Res 67: 303306.
  50. Krawczynski K, Meng XJ, Rybczynska J, , 2011. Pathogenetic elements of hepatitis E and animal models of HEV infection. Virus Res 161: 7883.[Crossref]
  51. Hosmillo M, Jeong YJ, Kim HJ, Park JG, Nayak MK, Alfajaro MM, Collantes TM, Park SJ, Ikuta K, Yunoki M, Kang MI, Park SI, Cho KO, , 2010. Molecular detection of genotype 3 porcine hepatitis E virus in aborted fetuses and their sows. Arch Virol 155: 11571161.[Crossref]
  52. Khuroo MS, Kamili S, Jameel S, , 1995. Vertical transmission of hepatitis E virus. Lancet 345: 10251026.[Crossref]
  53. Khuroo MS, , 2006. Association of severity of hepatitis E virus infection in the mother and vertically transmitted infection in the fetus. JK Pract 13: 7074.
  54. Kumar A, Beniwal M, Kar P, Sharma JB, Murthy NS, , 2004. Hepatitis E in pregnancy. Int J Gynaecol Obstet 85: 240244.[Crossref]
  55. Dahiya M, Kumar A, Kar P, Gupta RK, , 2005. Acute viral hepatitis in third trimester of pregnancy. Indian J Gastroenterol 24: 128129.
  56. Singh S, Mohanty A, Joshi YK, Deka D, Mohanty S, Panda SK, , 2003. Mother-to-child transmission of hepatitis E virus infection. Indian J Pediatr 70: 3739.[Crossref]
  57. Bonney JHM, Kwame-Aryee RAD, Obed SD, Tamatey AAD, Barnor JSD, Armah NBD, Oppong SAD, Osei-Kwasi MD, , 2012. Fatal hepatitis E viral infection in pregnant women in Ghana: a case series. BMC Res Notes 5: 478.[Crossref]
  58. Khuroo MS, Kamili S, , 2009. Clinical course and duration of viremia in vertically transmitted hepatitis E virus (HEV) infection in babies born to HEV-infected mothers. J Viral Hepat 16: 519523.[Crossref]
  59. Mansoor M, Raza H, Tariq R, , 2011. Feto-maternal outcome in HEV infection. Ann King Edward Med Univ 17: 8690.
  60. Pradhan M, Anand B, Singh A, , 2012. Hepatitis E virus infection causing isolated fetal ascites: a case report. Fetal Diagn Ther 32: 292294.[Crossref]
  61. Beasley RP, Hwang LY, Lee GC, Lan CC, Roan CH, Huang FY, Chen CL, , 1983. Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet 2: 10991102.[Crossref]
  62. Begum N, Polipalli SK, Husain SA, Kumar A, Kar P, , 2010. Duration of hepatitis E viremia in pregnancy. Int J Gynaecol Obstet 108: 207210.[Crossref]
  63. Aggarwal R, , 2011. Clinical presentation of hepatitis E. Virus Res 161: 1522.[Crossref]
  64. Gérolami R, Moal V, Colson P, , 2008. Chronic hepatitis E with cirrhosis in a kidney-transplant recipient. N Engl J Med 358: 859860.[Crossref]
  65. Kamar N, Selves J, Mansuy JM, Ouezzani L, Peron JM, Guitard J, Cointault O, Esposito L, Abravanel F, Danjoux M, Durand D, Vinel JP, Izopet J, Rostaing L, , 2008. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 358: 811817.[Crossref]
  66. Lockwood GL, Fernandez-Barredo S, Bendall R, Banks M, Ijaz S, Dalton HR, , 2008. Hepatitis E autochthonous infection in chronic liver disease. Eur J Gastroenterol Hepatol 20: 800803.[Crossref]
  67. Haagsma EB, van den Berg AP, Porte RJ, Benne CA, Vennema H, Reimerink JH, Koopmans MP, , 2008. Chronic hepatitis E virus infection in liver transplant recipients. Liver Transpl 14: 547553.[Crossref]
  68. Dalton HR, Bendall RP, Keane FE, Tedder RS, Ijaz S, , 2009. Persistent carriage of hepatitis E virus in patients with HIV infection. N Engl J Med 361: 10251027.[Crossref]
  69. Kamar N, Abravanel F, Selves J, Garrouste C, Esposito L, Lavayssière L, Cointault O, Ribes D, Cardeau I, Nogier MB, Mansuy JM, Muscari F, Peron JM, Izopet J, Rostaing L, , 2010. Influence of immunosuppressive therapy on the natural history of genotype 3 hepatitis-E virus infection after organ transplantation. Transplantation 89: 353360.[Crossref]
  70. Legrand-Abravanel F, Kamar N, Sandres-Saune K, Garrouste C, Dubois M, Mansuy JM, Muscari F, Sallusto F, Rostaing L, Izopet J, , 2010. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J Infect Dis 202: 835844.[Crossref]
  71. Renou C, Lafeuillade A, Cadranel JF, Pavio N, Pariente A, Allegre T, Poggi C, Penaranda G, Cordier F, Nicand E, ANGH; , 2010. Hepatitis E virus in HIV-infected patients. AIDS 24: 14931499.[Crossref]
  72. Halac U, Beland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F, , 2011. Chronic hepatitis E infection in children with liver transplantation. Gut 61: 597603.[Crossref]
  73. Dalton HR, Keane FE, Bendall R, Mathew J, Ijaz S, , 2011. Treatment of chronic hepatitis E in a patient with HIV infection. Ann Intern Med 155: 479480.[Crossref]
  74. Kamar N, Garrouste C, Haagsma EB, Garrigue V, Pischke S, Chauvet C, Dumortier J, Cannesson A, Cassuto-Viguier E, Thervet E, Conti F, Lebray P, Dalton HR, Santella R, Kanaan N, Essig M, Mousson C, Radenne S, Roque-Afonso AM, Izopet J, Rostaing L, , 2011. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 140: 14811489.[Crossref]
  75. Jagjit Singh GK, Ijaz S, Rockwood N, Farnworth SP, Devitt E, Atkins M, Tedder R, Nelson M, , 2011. Chronic hepatitis E as a cause for cryptogenic cirrhosis in HIV. J Infect 66: 103106.[Crossref]
  76. Colson P, Dhiver C, Poizot-Martin I, Tamalet C, Gérolami R, , 2011. Acute and chronic hepatitis E in patients infected with human immunodeficiency virus. J Viral Hepat 18: 227228.[Crossref]
  77. Motte A, Roquelaure B, Galambrun C, Bernard F, Zandotti C, Colson P, , 2012. Hepatitis E in three immunocompromized children in southeastern France. J Clin Virol 53: 162166.[Crossref]
  78. Halac U, Beland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F, , 2012. Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant. J Pediatr 160: 871874.e1.[Crossref]
  79. Pischke S, Stiefel P, Franz B, Bremer B, Suneetha PV, Heim A, Ganzenmueller T, Schlue J, Horn-Wichmann R, Raupach R, Darnedde M, Scheibner Y, Taubert R, Haverich A, Manns MP, Wedemeyer H, Bara CL, , 2012. Chronic hepatitis E in heart transplant recipients. Am J Transplant 12: 31283133.[Crossref]
  80. Lhomme S, Abravanel F, Dubois M, Sandres Saune K, Rostaing L, Kamar N, Izopet J, , 2012. Hepatitis E virus quasispecies and the outcome of acute hepatitis E in solid-organ transplant patients. J Virol 86: 1000610014.[Crossref]
  81. Scobie L, Dalton HR, , 2013. Hepatitis E: source and route of infection, clinical manifestations and new developments. J Viral Hepat 20: 111.[Crossref]
  82. Kamar N, Rostaing L, Izopet J, , 2013. Hepatitis E virus infection in immunosuppressed patients: natural history and therapy. Semin Liver Dis 33: 6270.[Crossref]
  83. Caron M, Bouscaillou J, Kazanji M, , 2012. Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa. Virol J 9: 254.[Crossref]
  84. Jaiswal SB, Chitnis DS, Asolkar MV, Naik G, Artwani KK, , 1996. Aetiology and prognostic factors in hepatic failure in central India. Trop Gastroenterol 17: 217220.
  85. Jaiswal SP, Jain AK, Naik G, Soni N, Chitnis DS, , 2001. Viral hepatitis during pregnancy. Int J Gynaecol Obstet 72: 103108.[Crossref]
  86. Jilani N, Das BC, Husain SA, Baweja UK, Chattopadhya D, Gupta RK, Sardana S, Kar P, , 2007. Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J Gastroenterol Hepatol 22: 676682.[Crossref]
  87. Kar P, Jilani N, Husain SA, Pasha ST, Anand R, Rai A, Das BC, , 2008. Does hepatitis E viral load and genotypes influence the final outcome of acute liver failure during pregnancy? Am J Gastroenterol 103: 24952501.[Crossref]
  88. Strand RT, Franque-Ranque M, Bergstrom S, Weiland O, , 2003. Infectious aetiology of jaundice among pregnant women in Angola. Scand J Infect Dis 35: 401403.[Crossref]
  89. Tsega E, Krawczynski K, Hansson BG, Nordenfelt E, , 1993. Hepatitis E virus infection in pregnancy in Ethiopia. Ethiop Med J 31: 173181.
  90. Sikder SS, Labrique AB, Ullah B, Ali H, Rashid M, Mehra S, Jahan N, Shamim AA, West KP, Christian P, , 2011. Accounts of severe acute obstetric complications in rural Bangladesh. BMC Pregnancy Childbirth 11: 76.[Crossref]
  91. Filippi V, Richard F, Lange I, Ouattara F, , 2009. Identifying barriers from home to the appropriate hospital through near-miss audits in developing countries. Best Pract Res Clin Obstet Gynaecol 23: 389400.[Crossref]
  92. Hamid SS, Jafri SM, Khan H, Shah H, Abbas Z, Fields H, , 1996. Fulminant hepatic failure in pregnant women: acute fatty liver or acute viral hepatitis? J Hepatol 25: 2027.[Crossref]
  93. Aggarwal R, , 2003. Hepatic encephalopathy in pregnancy. Indian J Gastroenterol 22 (Suppl 2): S78S80.
  94. Jayanthi V, Udayakumar N, , 2008. Acute liver failure in pregnancy: an overview. Minerva Gastroenterol Dietol 54: 7584.
  95. Devarbhavi H, Kremers WK, Dierkhising R, Padmanabhan L, , 2008. Pregnancy-associated acute liver disease and acute viral hepatitis: differentiation, course and outcome. J Hepatol 49: 930935.[Crossref]
  96. Mast EE, Alter MJ, Holland PV, Purcell RH, , 1998. Evaluation of assays for antibody to hepatitis E virus by a serum panel. Hepatitis E Virus Antibody Serum Panel Evaluation Group. Hepatology 27: 857861.[Crossref]
  97. Bose PD, Das BC, Kumar A, Gondal R, Kumar D, Kar P, , 2011. High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. J Hepatol 54: 11071113.[Crossref]
  98. Mishra N, Walimbe AM, Arankalle VA, , 2013. Hepatitis E virus from India exhibits significant amino acid mutations in fulminant hepatic failure patients. Virus Genes 46: 4753.[Crossref]
  99. Stoszek SK, Abdel-Hamid M, Saleh DA, El Kafrawy S, Narooz S, Hawash Y, Shebl FM, El Daly M, Said A, Kassem E, Mikhail N, Engle RE, Sayed M, Sharaf S, Fix AD, Emerson SU, Purcell RH, Strickland GT, , 2006. High prevalence of hepatitis E antibodies in pregnant Egyptian women. Trans R Soc Trop Med Hyg 100: 95101.[Crossref]
  100. Labrique AB, Zaman K, Hossain Z, Saha P, Yunus M, Hossain A, Ticehurst JR, Nelson KE, , 2010. Epidemiology and risk factors of incident hepatitis E virus infections in rural Bangladesh. Am J Epidemiol 172: 952961.[Crossref]
  101. Mishra N, Arankalle VA, , 2011. Association of polymorphisms in the promoter regions of TNF-alpha (−308) with susceptibility to hepatitis E virus and TNF-alpha (−1031) and IFN-gamma (+874) genes with clinical outcome of hepatitis E infection in India. J Hepatol 55: 12271234.[Crossref]
  102. Cardenas I, Means RE, Aldo P, Koga K, Lang SM, Booth CJ, Manzur A, Oyarzun E, Romero R, Mor G, , 2010. Viral infection of the placenta leads to fetal inflammation and sensitization to bacterial products predisposing to preterm labor. J Immunol 185: 12481257.[Crossref]
  103. Cardenas I, Mor G, Aldo P, Lang SM, Stabach P, Sharp A, Romero R, Mazaki-Tovi S, Gervasi M, Means RE, , 2011. Placental viral infection sensitizes to endotoxin-induced pre-term labor: a double hit hypothesis. Am J Reprod Immunol 65: 110117.[Crossref]
  104. Gerolami R, Borentain P, Raissouni F, Motte A, Solas C, Colson P, , 2011. Treatment of severe acute hepatitis E by ribavirin. J Clin Virol 52: 6062.[Crossref]
  105. Karim F, Rahman S, Al-Mahtab M, Ahmed F, , 2012. Successful treatment of severe hepatitis E with ribavirin: a case report from Bangladesh. Euroasian J Hepato-Gastroenterol 2: 5657.[Crossref]
  106. Pischke S, Hardtke S, Bode U, Birkner S, Chatzikyrkou C, Kauffmann W, Bara CL, Gottlieb J, Wenzel J, Manns MP, Wedemeyer H, , 2013. Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience. Liver Int 33: 722726.[Crossref]
  107. State of Florida Department of Health Central Pharmacy, 2010. National Library of Medicine (NLM) DailyMed Database, 2010. Available at: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3b8b0c65-e466-4662-9e85-5a253d31ebe8. Accessed November 1, 2012.
  108. Navaneethan U, Al Mohajer M, Shata MT, , 2008. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int 28: 11901199.[Crossref]
  109. Shrestha MP, Scott RM, Joshi DM, Mammen MP, Jr Thapa GB, Thapa N, Myint KS, Fourneau M, Kuschner RA, Shrestha SK, David MP, Seriwatana J, Vaughn DW, Safary A, Endy TP, Innis BL, , 2007. Safety and efficacy of a recombinant hepatitis E vaccine. N Engl J Med 356: 895903.[Crossref]
  110. Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Wang H, Yang CL, Jiang HM, Cai JP, Wang YJ, Ai X, Hu YM, Tang Q, Yao X, Yan Q, Xian YL, Wu T, Li YM, Miao J, Ng MH, Shih JW, Xia NS, , 2010. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 376: 895902.[Crossref]
  111. Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Yao X, Liang ZL, Wu T, Li JX, Yan Q, Yang CL, Jiang HM, Huang HJ, Xian YL, Shih JWK, Ng MH, Li YM, Wang JZ, Zhu FC, Xia NS, , 2013. Protection against hepatitis E virus by naturally acquired and vaccine induced immunity. Clin Microbiol Infect, online ahead of print. doi:10.1111/1469-0691.12419.
  112. Wu T, Zhu FC, Huang SJ, Zhang XF, Wang ZZ, Zhang J, Xia NS, , 2011. Safety of the hepatitis E vaccine for pregnant women: a preliminary analysis. Hepatology 55: 2038.[Crossref]
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  • Received : 15 May 2013
  • Accepted : 19 Nov 2013

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