Volume 90, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A molecular screening of wild-caught rodents was conducted in French Guiana, South America to identify hosts of the hantavirus Maripa described in 2008 in a hantavirus pulmonary syndrome (HPS) case. Over a 9-year period, 418 echimyids and murids were captured. Viral RNA was detected in two sigmodontine rodents, and , trapped close to the house of a second HPS case that occurred in 2009 and an close to the fourth HPS case identified in 2013. Sequences from the rodents had 96% and 97% nucleotide identity (fragment of S and M segments, respectively) with the sequence of the first human HPS case. Phylogenetic reconstructions based on the complete sequence of the S segment show that Maripa virus is closely related to Rio Mamore hantavirus. Using environmental descriptors of trapping sites, including vegetation, landscape units, rain, and human disturbance, a maximal entropy-based species distribution model allowed for identification of areas of higher predicted occurrence of the two rodents, where emergence risks of Maripa virus are expected to be higher.


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  1. Jonsson CB, Figueiredo LT, Vapalahti O, , 2010. A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev 23: 412441.[Crossref] [Google Scholar]
  2. Allen LJS, McCormack RK, Jonsson CB, , 2006. Mathematical models for hantavirus infection in rodents. Bull Math Biol 68: 511524.[Crossref] [Google Scholar]
  3. Sauvage F, Langlais M, Pontier D, , 2007. Predicting the emergence of human hantavirus disease using a combination of viral dynamics and rodent demographic patterns. Epidemiol Infect 135: 4656.[Crossref] [Google Scholar]
  4. Carroll DS, Mills JN, Montgomery JM, Bausch DG, Blair PJ, Burans JP, Felices V, Gianella A, Iihoshi N, Nichol ST, Olson JG, Rogers DS, Salazar M, Ksiazek TG, , 2005. Hantavirus pulmonary syndrome in central Bolivia: relationships between reservoir hosts, habitats, and viral genotypes. Am J Trop Med Hyg 72: 4246. [Google Scholar]
  5. Mills JN, Schmidt K, Ellis BA, Calderón G, Enria D, Ksiazek TG, , 2007. A longitudinal study of hantavirus infection in three sympatric reservoir species in agroecosystems on the Argentine Pampa. Vector Borne Zoonotic Dis 7: 229240.[Crossref] [Google Scholar]
  6. Patterson BD, , 1994. Accumulating knowledge on the dimensions of biodiversity: systematic perspectives on Neotropical mammals. Biodivers Lett 2: 7986.[Crossref] [Google Scholar]
  7. Rosa ES, Mills JN, Padula PJ, Elkhoury MR, Ksiazek TG, Mendes WS, Santos ED, Araújo GC, Martinez VP, Rosa JF, Edelstein A, Vasconcelos PF, , 2005. Newly recognized hantaviruses associated with hantavirus pulmonary syndrome in northern Brazil: partial genetic characterization of viruses and serologic implication of likely reservoirs. Vector Borne Zoonotic Dis 5: 1119.[Crossref] [Google Scholar]
  8. Medeiros DB, da Rosa ES, Marques AA, Simith DB, Carnero AR, Chiang JO, Prazeres ITE, Vasconcelos PFC, Nunes MRT, , 2010. Circulation of hantaviruses in the influence area of the Cuiabá-Santarém Highway. Mem Inst Oswaldo Cruz 105: 665671.[Crossref] [Google Scholar]
  9. Travassos da Rosa ES, Medeiros DB, Nunes MR, Simith DB, de Souza Pereira A, Elkhoury MR, Lavocat M, Marques AAR, Via AV, D'Andrea P, Bonvincino CR, Lemos ERS, Vasconcelos PFC, , 2011. Pygmy rice rat as potential host of Castelo dos Sonhos Hantavirus. Emerg Infect Dis 17: 15271530.[Crossref] [Google Scholar]
  10. Firth C, Tokarz A, Simith DB, Nunes MRT, Bhat M, Rosa EST, Medeiros DBA, Palacio G, Vasconcelos PFC, Lipkin WI, , 2012. Diversity and distribution of hantaviruses in South America. J Virol 84: 1375613766.[Crossref] [Google Scholar]
  11. Matheus S, Djossou F, Moua D, Bourbigot AM, Hommel D, Lacoste V, Dussart P, Lavergne A, , 2010. Hantavirus pulmonary syndrome, French Guiana. Emerg Infect Dis 16: 739741.[Crossref] [Google Scholar]
  12. Lim BK, , 2012. Preliminary assessment of neotropical mammal DNA barcodes: an underestimation of biodiversity. Open Zool J 5: 1017.[Crossref] [Google Scholar]
  13. Johnson AM, Bowen MD, Ksiazek TG, Williams RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST, , 1997. Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238: 115127.[Crossref] [Google Scholar]
  14. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S, , 2011. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28: 27312739.[Crossref] [Google Scholar]
  15. Nylander JAA, , 2004. MrModeltest v2. Uppsala, Sweden: Evolutionary Biology Centre, Uppsala University. [Google Scholar]
  16. Ronquist F, Huelsenbeck JP, , 2003. MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics 19: 15721574.[Crossref] [Google Scholar]
  17. Matheus S, Lavergne A, de Thoisy B, Dussart P, Lacoste V, , 2012. Complete genome sequence of a novel hantavirus variant of Rio Mamoré virus, Maripa virus, from French Guiana. J Virol 86: 5399.[Crossref] [Google Scholar]
  18. Billings AN, Rollin PE, Milazzo ML, Molina CP, Eyzaguirre EJ, Livingstone W, Ksiazek TG, Fulhorst CF, , 2010. Pathology of Black Creek Canal virus infection in juvenile hispid cotton rats (Sigmodon hispidus). Vector Borne Zoonotic Dis 10: 621628.[Crossref] [Google Scholar]
  19. Boone JD, Otteson EW, McGwire KC, Villard P, Rowe JE, St Jeor SC, , 1998. Ecology and demographics of hantavirus infections in rodent populations in the Walker River Basin of Nevada and California. Am J Trop Med Hyg 59: 445451. [Google Scholar]
  20. Vincent MJ, Quiroz E, Gracia F, Sanchez AJ, Ksiazek TG, Kitsutani PT, Ruedas LA, Tinnin DS, Caceres L, Garcia A, Rollin PE, Mills JN, Peters CJ, Nichol ST, , 2000. Hantavirus pulmonary syndrome in Panama: identification of novel hantaviruses and their likely reservoirs. Virology 277: 1419.[Crossref] [Google Scholar]
  21. Suzan G, Giermakowski JT, Marce E, Suzan-Azpiri H, Armién B, Yates TL, , 2006. Modeling hantavirus reservoir species dominance in high seroprevalence areas on the Azuero Peninsula of Panama. Am J Trop Med Hyg 74: 11031110. [Google Scholar]
  22. Chu YK, Goodin D, Owen RD, Koch D, Jonsson CB, , 2009. Sympatry of 2 hantavirus strains, Paraguay, 2003–2007. Emerg Infect Dis 15: 19771980.[Crossref] [Google Scholar]
  23. Milazzo ML, Cajimat MN, Hanson JD, Bradley RD, Quintana M, Sherman C, Velásquez RT, Fulhorst CF, , 2006. Catacamas virus, a hantaviral species naturally associated with Oryzomys couesi (Coues' oryzomys) in Honduras. Am J Trop Med Hyg 75: 10031010. [Google Scholar]
  24. Raboni SM, Hoffmann FG, Oliveira RC, Teixeira BR, Bonvincino CR, Stella RC, Carstensen S, Bordignon J, D'Andrea PS, Lemos ERS, do Santos CND, , 2009. Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil). J Gen Virol 90: 21662171.[Crossref] [Google Scholar]
  25. Wisz MS, Hijmans RJ, Li R, Peterson AT, Graham CH, Guisan A, , 2008. Effects of sample size on the performance of species distribution models. Divers Distrib 14: 763773.[Crossref] [Google Scholar]
  26. Phillips SJ, Anderson RP, Schapire RE, , 2006. Maximum entropy modeling of species geographic distributions. Ecol Modell 190: 231259.[Crossref] [Google Scholar]
  27. Voss RS, , 1991. An introduction to the Neotropical muroid rodent genus Zygodontomys . B Am Mus Nat Hist 210: 1113. [Google Scholar]
  28. Gond V, Freycon V, Molino JF, Brunaux O, Ingrassia F, Joubert P, Pekel JF, Prévost MF, Thierron V, Trombe PJ, Sabatier D, , 2011. Broad-scale spatial pattern of forest landscapes types in the Guiana shield. Int J Appl Earth Obs Geoinf 13: 357367.[Crossref] [Google Scholar]
  29. Guitet S, Cornu JF, Brunaux O, Betbeder J, Carozza JM, Richard-Hansen C, , 2013. Landform and landscape mapping, French Guiana (South America). J Maps, doi:10.1080/17445647.2013.785371. [Google Scholar]
  30. de Thoisy B, Richard-Hansen C, Goguillon B, Joubert P, Obstancias J, Winterton P, Brosse S, , 2010. Rapid evaluation of threats to biodiversity: human footprint score and large vertebrate species responses in French Guiana. Biodivers Conserv 19: 15671584.[Crossref] [Google Scholar]
  31. Dudík M, Schapire RE, Phillips SJ, , 2005. Correcting sample selection bias in maximum entropy density estimation. Adv Neural Inf Process Syst 18: 323330. [Google Scholar]
  32. Raes N, ter Steege H, , 2007. A null-model for significance testing of presence-only species distribution models. Ecography (Cop.) 30: 727736.[Crossref] [Google Scholar]
  33. Wilson DE, Reeder DM, , eds. 2005. Mammal Species of the World. A Taxonomic and Geographic Reference. Baltimore, MD: The Johns Hopkins University Press. [Google Scholar]

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  • Received : 13 May 2013
  • Accepted : 17 Feb 2014
  • Published online : 04 Jun 2014

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