1921
Volume 90, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The cornerstone of schistosomiasis control is mass praziquantel treatment in high prevalence areas. Adults are an important target population, given increasing recognition of the burden of male and female genital schistosomiasis. However, use of weighing scales to calculate praziquantel dosing in rural areas can be challenging. For school-age children, the World Health Organization (WHO) has approved a dose pole to simplify praziquantel dosing based on height. We modified the pediatric dose pole by adding two height categories and incorporating a simple overweight/obesity adjustment, for simplified mass treatment of adults in sub-Saharan Africa. Using the rural Zimbabwean Demographic and Health Survey data, we show that the modified dose pole with body mass index adjustment would result in > 98% of adults receiving an acceptable dose (30–60 mg/kg), with only 1.4% and 0.3% receiving an inadequate dose (< 30 mg/kg) or high dose (> 60 mg/kg), respectively. An adult dose pole may provide a more feasible alternative to weighing scales in community-based praziquantel treatment programs.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.13-0252
2014-04-02
2017-11-18
Loading full text...

Full text loading...

/deliver/fulltext/14761645/90/4/634.html?itemId=/content/journals/10.4269/ajtmh.13-0252&mimeType=html&fmt=ahah

References

  1. World Health Organization, 2006. Preventive Chemotherapy in Human Helminthiasis. Geneva: World Health Organization. Available at: http://www.who.int/schistosomiasis/strategy/en/index.html. Accessed April 16, 2013.
  2. Montresor A, Engels D, Chitsulo L, Bundy DA, Brooker S, Savioli L, , 2001. Development and validation of a ‘tablet pole’ for the administration of praziquantel in sub-Saharan Africa. Trans R Soc Trop Med Hyg 95: 542544.[Crossref]
  3. Montresor A, Odermatt P, Muth S, Iwata F, Raja'a YA, Assis AM, Zulkifli A, Kabatereine NB, Fenwick A, Al-Awaidy S, Allen H, Engels D, Savioli L, , 2005. The WHO dose pole for the administration of praziquantel is also accurate in non-African populations. Trans R Soc Trop Med Hyg 99: 7881.[Crossref]
  4. World Health Organization, 2011. Report of a meeting to review the results of studies on the treatment of schistosomiasis in preschool-age children. Geneva: World Health Organization. Available at: http://www.who.int/schistosomiasis/archives/en/. Accessed November 10, 2013.
  5. Sousa-Figueiredo JC, Betson M, Stothard JR, , 2012. Treatment of schistosomiasis in African infants and preschool-aged children: downward extension and biometric optimization of the current praziquantel dose pole. In Health 4: 95102.[Crossref]
  6. Downs JA, Mguta C, Kaatano GM, Mitchell KB, Bang H, Simplice H, Kalluvya SE, Changalucha JM, Johnson WD, Jr Fitzgerald DW, , 2011. Urogenital schistosomiasis in women of reproductive age in Tanzania's Lake Victoria region. Am J Trop Med Hyg 84: 364369.[Crossref]
  7. Kjetland EF, Ndhlovu PD, Gomo E, Mduluza T, Midzi N, Gwanzura L, Midzi N, Mason PR, Friis H, Gundersen SG, , 2006. Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS 20: 593600.[Crossref]
  8. Mbabazi PS, Andan O, Fitzgerald DW, Chitsulo L, Engels D, Downs JA, , 2011. Examining the relationship between urogenital schistosomiasis and HIV infection. PLoS Negl Trop Dis 5: e1396.[Crossref]
  9. World Health Organization, 2002. Report of the WHO Informal Consultation on the Use of Praziquantel during Pregnancy/Lactation and Albendazole/Mebendazole in Children under 24 Months. Geneva: World Health Organziation. Available at: http://apps.who.int/iris/bitstream/10665/68041/1/WHO_CDS_CPE_PVC_2002.4.pdf. Accessed April 16, 2013.
  10. Keshtkar AA, Semnani S, Pourshams A, Khademi H, Roshandel G, Boffetta P, Malekzadeh R, , 2010. Pictogram use was validated for estimating individual's body mass index. J Clin Epidemiol 63: 655659.[Crossref]
  11. Stunkard AJ, Sorensen T, Schulsinger F, , 1983. Use of the Danish Adoption Register for the study of obesity and thinness. Res Publ Assoc Res Nerv Ment Dis 60: 115120.
  12. World Health Organization, 2012. Schistosomiasis. Fact Sheet No. 115, March 2013. Geneva: World Health Organization. Available at: http://www.who.int/mediacentre/factsheets/fs115/en/. Accessed April 17, 2013.
  13. Baalwa J, Byarugaba BB, Kabagambe EK, Otim AM, , 2010. Prevalence of overweight and obesity in young adults in Uganda. Afr Health Sci 10: 367373.
  14. Shayo GA, Mugusi FM, , 2011. Prevalence of obesity and associated risk factors among adults in Kinondoni municipal district, Dar es Salaam Tanzania. BMC Public Health 11: 365.[Crossref]
  15. Patt MR, Lane AE, Finney CP, Yanek LR, Becker DM, , 2002. Body image assessment: comparison of figure rating scales among urban Black women. Ethn Dis 12: 5462.
  16. Jordan I, Hebestreit A, Swai B, Krawinkel MB, , 2013. Breast cancer risk among women with long-standing lactation and reproductive parameters at low risk level: a case-control study in northern Tanzania. Breast Cancer Res Treat 142: 133141.[Crossref]
  17. Strandgaard H, Johansen MV, Montresor A, Ornbjerg N, , 2007. Field testing of the WHO dose pole for administration of praziquantel in the treatment of opisthorchiasis in Lao PDR. Trans R Soc Trop Med Hyg 101: 11201123.[Crossref]
  18. Alexander ND, Cousens SN, Yahaya H, Abiose A, Jones BR, , 1993. Ivermectin dose assessment without weighing scales. Bull World Health Organ 71: 361366.
  19. Bulik CM, Wade TD, Heath AC, Martin NG, Stunkard AJ, Eaves LJ, , 2001. Relating body mass index to figural stimuli: population-based normative data for caucasians. Int J Obes Relat Metab Disord 25: 15171524.[Crossref]
  20. Harris CV, Bradlyn AS, Coffman J, Gunel E, Cottrell L, , 2008. BMI-based body size guides for women and men: development and validation of a novel pictorial method to assess weight-related concepts. Int J Obes (Lond) 32: 336342.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.13-0252
Loading
/content/journals/10.4269/ajtmh.13-0252
Loading

Data & Media loading...

  • Received : 08 May 2013
  • Accepted : 05 Jan 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error