Volume 89, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Two cases of domestically acquired fascioliasis are reported. Patient One was a 63-year-old male who developed a febrile illness 2 months after eating watercress in Marin County. Patient Two was a 38-year-old male who had eaten watercress with Patient One, and also developed a febrile illness. Both patients had eosinophilia and liver lesions on imaging. Diagnosis was made by serology and treatment was with triclabendazole.


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  1. Keiser J, Utzinger J, , 2005. Emerging foodborne trematodiasis. Emerg Infect Dis 11: 15071514.[Crossref]
  2. Marcos LA, Terashima A, Gotuzzo E, , 2008. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis 21: 523530.[Crossref]
  3. Cabada MM, White AC, Jr, 2012. New developments in epidemiology, diagnosis, and treatment of fascioliasis. Curr Opin Infect Dis 25: 518522.[Crossref]
  4. Welch RD, Smith PH, Malone JB, Holmes RA, Geaghan JP, , 1987. Herd evaluation of Fasciola hepatica infection levels in Louisiana cattle by an enzyme-linked immunosorbent assay. Am J Vet Res 48: 345347.
  5. Knapp SE, Dunkel AM, Han K, Zimmerman LA, , 1992. Epizootiology of fascioliasis in Montana. Vet Parasitol 42: 241246.[Crossref]
  6. Kane YI, , 2010. A Walk on the Wild Side—for Lunch. Wall Street Journal. New York: Dow Jones and Company, Inc. Available at: http://online.wsj.com/article/SB10001424052748704631504575532072467298394.html. Accessed January 26, 2013.
  7. Fried B, Abruzzi A, , 2010. Food-borne trematode infections of humans in the United States of America. Parasitol Res 106: 12631280.[Crossref]
  8. Norton RA, Monroe L, , 1961. Infection by Fasciola hepatica acquired in California. Gastroenterology 41: 4648.
  9. MacLean JD, Graeme-Cook FM, , 2002. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-2002. A 50-year-old man with eosinophilia and fluctuating hepatic lesions. N Engl J Med 346: 12321239.[Crossref]
  10. Hauser SC, Bynum TE, , 1984. Abnormalities on ERCP in a case of human fascioliasis. Gastrointest Endosc 30: 8082.[Crossref]
  11. Hillyer GV, Soler de Galanes M, , 1988. Identification of a 17-kilodalton Fasciola hepatica immunodiagnostic antigen by the enzyme-linked immunoelectrotransfer blot technique. J Clin Microbiol 26: 20482053.
  12. Esteban J, Barges M, Mas-Coma S, , 1998. Geographical distribution, diagnosis and treatment of human fascioliasis: a review. Res Rev Parisitol 58: 1342.
  13. Fürst T, Keiser J, Utzinger J, , 2012. Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. Lancet Infect Dis 12: 210221.[Crossref]
  14. Mas-Coma S, , 2005. Epidemiology of fascioliasis in human endemic areas. J Helminthol 79: 207216.[Crossref]
  15. Mas-Coma MS, Esteban JG, Bargues MD, , 1999. Epidemiology of human fascioliasis: a review and proposed new classification. Bull World Health Organ 77: 340346.
  16. Fürst T, Sayasone S, Odermatt P, Keiser J, Utzinger J, , 2012. Manifestation, diagnosis, and management of foodborne trematodiasis. BMJ 344: e4093.[Crossref]
  17. Haag E, , 2007. Enemy within. Angus Journal 29: 255257. Available at: http://www.angusjournal.com/ArticlePDF/enemywithin.pdf. Accessed April, 4, 2013.
  18. Freeborn S, , 1928. Liver Fluke and Stomach Worm of Sheep. California Agricultural Extension Service, Circular 17. The College of Agriculture, University of California. Available at: http://ia600700.us.archive.org/35/items/liverflukestomac17free/liverflukestomac17free.pdf. Accessed April 4, 2013.
  19. Fox NJ, White PC, McClean CJ, Marion G, Evans A, Hutchings MR, , 2011. Predicting impacts of climate change on Fasciola hepatica risk. PLoS ONE 6: e16126.[Crossref]
  20. Neff GW, Dinavahi RV, Chase V, Reddy KR, , 2001. Laparoscopic appearance of Fasciola hepatica infection. Gastrointest Endosc 53: 668671.[Crossref]
  21. Stemmermann GN, , 1953. Human infestation with Fasciola gigantica . Am J Pathol 29: 731759.
  22. Alatoom A, Sheffield J, Gander RM, Shaw J, Cavuoti D, , 2008. Fascioliasis in pregnancy. Obstet Gynecol 112: 483485.[Crossref]
  23. Agnamey P, Fortes-Lopes E, Raccurt CP, Boncy J, Totet A, , 2012. Cross-sectional serological survey of human fascioliasis in Haiti. J Parasitol Res 2012: 751951.[Crossref]
  24. Martínez-Barbabosa I, Gutiérrez-Quiroz M, Romero-Cabello R, Ruiz-González L, Gutiérrez-Cárdenas EM, Alpizar-Sosa A, Pimienta-Lastra RdJ, , 2006. Seroepidemiology of fascioliasis in school children in Mexico City. Rev Biomed 17: 251257. Available at: http://www.medigraphic.com/pdfs/revbio/bio-2006/bio064c.pdf. Accessed April 4, 2013.
  25. Marcos LA, Tagle M, Terashima A, Bussalleu A, Ramirez C, Carrasco C, Valdez L, Huerta-Mercado J, Freedman DO, Vinetz JM, Gotuzzo E, , 2008. Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis. Am J Trop Med Hyg 78: 222227.
  26. Graham CS, Brodie SB, Weller PF, , 2001. Imported Fasciola hepatica infection in the United States and treatment with triclabendazole. Clin Infect Dis 33: 15.[Crossref]
  27. Favennec L, Jave Ortiz J, Gargala G, Lopez Chegne N, Ayoub A, Rossignol JF, , 2003. Double-blind, randomized, placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru. Aliment Pharmacol Ther 17: 265270.[Crossref]
  28. Apt W, Aguilera X, Vega F, Miranda C, Zulantay I, Perez C, Gabor M, Apt P, , 1995. Treatment of human chronic fascioliasis with triclabendazole: drug efficacy and serologic response. Am J Trop Med Hyg 52: 532535.
  29. Hien TT, Truong NT, Minh NH, Dat HD, Dung NT, Hue NT, Dung TK, Tuan PQ, Campbell JI, Farrar JJ, Day JN, , 2008. A randomized controlled pilot study of artesunate versus triclabendazole for human fascioliasis in central Vietnam. Am J Trop Med Hyg 78: 388392.
  30. Cuffari C, Oligny L, Seidman EG, , 1998. Dientamoeba fragilis masquerading as allergic colitis. J Pediatr Gastroenterol Nutr 26: 1620.[Crossref]
  31. Sorvillo F, Ash LR, Berlin OG, Morse SA, , 2002. Baylisascaris procyonis: an emerging helminthic zoonosis. Emerg Infect Dis 8: 355359.[Crossref]

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  • Received : 06 Feb 2013
  • Accepted : 05 Jun 2013

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