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Volume 89, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Unresolved Problems Related to Scrub Typhus: A Seriously Neglected Life-Threatening Disease, Page 1 of 1

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References

  1. Traub R, Wisseman CL, Jr, 1974. The ecology of chigger-borne rickettsiosis (scrub typhus). J Med Entomol 11: 237303.[Crossref]
  2. Roberts LW, Rapmund G, Cadigan FC, Jr, 1977. Sex ratios in Rickettsia tsutsugamushi-infected and noninfected colonies of Leptotrombidium (Acari:Trombiculidae). J Med Entomol 14: 8992.[Crossref]
  3. Roberts LW, Muul I, Robinson DM, , 1977. Numbers of Leptotrombidium (Leptotrombidium) deliense (Acarina: trombiculidae) and prevalence of Rickettsia tsutsugamushi in adjacent habitats of peninsular Malaysia. Southeast Asian J Trop Med Public Health 8: 207213.
  4. Traub R, Wisseman CL, Jr Jones MR, O'Keefe JJ, , 1975. The acquisition of Rickettsia tsutsugamushi by chiggers (trombiculid mites) during the feeding process. Ann N Y Acad Sci 266: 91114.[Crossref]
  5. Walker JS, Chan CT, Manikumaran C, Elisberg BL, , 1975. Attempts to infect and demonstrate transovarial transmission of R. tsutsugamushi in three species of Leptotrombidium mites. Ann N Y Acad Sci 266: 8090.[Crossref]
  6. Takahashi M, Murata M, Machida K, Hori E, Kawamura A, Jr Tanaka H, , 1990. Aggregated distribution of infective spots composed of Leptotrombidium pallidum, highly prevalent with Rickettsia tsutsugamushi, demonstrated by sentinel voles, Microtus montebelli, on the ground. Jpn J Exp Med 60: 325335.
  7. Frances SP, Watcharapichat P, Phulsuksombati D, Tanskul P, , 2000. Transmission of Orientia tsutsugamushi, the aetiological agent for scrub typhus, to co-feeding mites. Parasitology 120: 601607.[Crossref]
  8. Urakami H, Takahashi M, Murata M, Tamura A, , 1994. Electron microscopic study of the distribution and the vertical transmission of Rickettsia tsutsugamushi in Leptotrombidium pallidum . Jpn J Med Sci Biol 47: 127139.[Crossref]
  9. Nakayama K, Kurokawa K, Fukuhara M, Urakami H, Yamamoto S, Yamazaki K, Ogura Y, Ooka T, Hayashi T, , 2010. Genome comparison and phylogenetic analysis of Orientia tsutsugamushi strains. DNA Res 17: 281291.[Crossref]
  10. Rosenburg R, , 1997. Drug-resistant scrub typhus: paradigm and paradox. Parasitol Today 13: 131132.[Crossref]
  11. Watt G, Parola P, , 2003. Scrub typhus and tropical rickettsioses. Curr Opin Infect Dis 16: 429436.[Crossref]
  12. Rapmund G, , 1984. Rickettsial diseases of the Far East: new perspectives. J Infect Dis 149: 330338.[Crossref]
  13. Kelly DJ, Fuerst PA, Ching WM, Richards AL, , 2009. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi . Clin Infect Dis 48 (Suppl 3): S203S230.[Crossref]
  14. Osuga K, Kimura M, Goto H, Shimada K, Suto T, , 1991. A case of Tsutsugamushi disease probably contracted in Africa. Eur J Clin Microbiol Infect Dis 10: 9596.[Crossref]
  15. Ghorbani RP, Ghorbani AJ, Jain MK, Walker DH, , 1997. A case of scrub typhus probably acquired in Africa. Clin Infect Dis 25: 14731474.[Crossref]
  16. Izzard L, Fuller A, Blacksell SD, Paris DH, Richards AL, Aukkanit N, Nguyen C, Jiang J, Fenwick S, Day NP, Graves S, Stenos J, , 2010. Isolation of a novel Orientia species (O. chuto sp. nov.) from a patient infected in Dubai. J Clin Microbiol 8: 44044409.[Crossref]
  17. Balcells ME, Rabagliati R, García P, Poggi H, Oddó D, Concha M, Abarca K, Jiang J, Kelly DJ, Richards AL, Fuerst PA, , 2011. Endemic scrub typhus-like illness, Chile. Emerg Infect Dis 17: 16591663.[Crossref]
  18. Manosroi J, Chutipongvivate S, Auwanit W, Manosroi A, , 2006. Determination and geographic distribution of Orientia tsutsugamushi serotypes in Thailand by nested polymerase chain reaction. Diagn Microbiol Infect Dis 55: 185190.[Crossref]
  19. Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN, , 2006. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis 12: 256262.[Crossref]
  20. Brown GW, Robinson DM, Huxsoll DL, Ng TS, Lim KJ, , 1976. Scrub typhus: a common cause of illness in indigenous populations. Trans R Soc Trop Med Hyg 70: 444448.[Crossref]
  21. Brown GW, Robinson DM, Huxsoll DL, , 1978. Serological evidence for a high incidence of transmission of Rickettsia tsutsugamushi in two Orang Asli settlements in Peninsular Malaysia. Am J Trop Med Hyg 27: 121123.
  22. Chanyasanha C, Kaeburong K, Chenchittikul M, Sujirarat D, , 1998. Seroprevalence of scrub typhus infection in patients with pyrexia at some malaria clinics in three western provinces of Thailand. Asian Pac J Allergy Immunol 16: 119125.
  23. Corwin A, Soderquist R, Suwanabun N, Sattabongkot J, Martin L, Kelly D, Beecham J, , 1999. Scrub typhus and military operations in Indochina. Clin Infect Dis 29: 940941.[Crossref]
  24. World Health Organization Department of Communicable Disease Surveillance and Response, 1999. WHO Recommended Surveillance Standards, Vol 2. Geneva: World Health Organization.
  25. Spicer PE, Taufa T, Benjamin AL, , 2007. Scrub typhus (Orientia tsutsugamushi), spotted fever (Rickettsia australis) and dengue fever as possible causes of mysterious deaths in the Strickland Gorge area of Southern Highlands and West Sepik Provinces of Papua New Guinea. P N G Med J 50: 172183.
  26. Mathai E, Rolain JM, Verghese L, Mathai M, Jasper P, Verghese G, Raoult D, , 2003. Case reports: scrub typhus during pregnancy in India. Trans R Soc Trop Med Hyg 97: 570572.[Crossref]
  27. Lewis MD, Yousuf AA, Lerdthusnee K, Razee A, Chandranoi K, Jones JW, , 2003. Scrub typhus reemergence in the Maldives. Emerg Infect Dis 9: 16381641.[Crossref]
  28. Premaratna R, Loftis AD, Chandrasena TG, Dasch GA, de Silva HJ, , 2008. Rickettsial infections and their clinical presentations in the Western Province of Sri Lanka: a hospital-based study. Int J Infect Dis 12: 198202.[Crossref]
  29. Chong Y, , 1989. Application of serologic diagnosis of Tsutsugamushi disease (scrub typhus) in Korea where the disease was recently recognized to be endemic. Yonsei Med J 30: 111117.[Crossref]
  30. Chang WH, Kang JS, Lee WK, Choi MS, Lee JH, , 1990. Serological classification by monoclonal antibodies of Rickettsia tsutsugamushi isolated in Korea. J Clin Microbiol 28: 685688.
  31. Liu YX, Jia N, Suo JJ, Xing YB, Liu G, Xiao HJ, Jia N, Zhao ZT, Min JS, Feng PT, Ma SB, Richardus JH, Cao WC, , 2009. Characteristics of pediatric scrub typhus in a new endemic region of northern China. Pediatr Infect Dis J 28: 11111114.[Crossref]
  32. Zhang S, Song H, Liu Y, Li Q, Wang Y, Wu J, Wan J, Li G, Yu C, Li X, Yin W, Xu Z, Liu B, Zhang Q, Wan K, Li G, Fu X, Zhang J, He J, Hai R, Yu D, Walker DH, Xu J, Yu XJ, , 2010. Scrub typhus in previously unrecognized areas of endemicity in China. J Clin Microbiol 48: 12411244.[Crossref]
  33. Zhang M, Zhao ZT, Wang XJ, Li Z, Ding L, Ding SJ, , 2012. Scrub typhus: surveillance, clinical profile and diagnostic issues in Shandong, China. Am J Trop Med Hyg 87: 10991104.[Crossref]
  34. Paris DH, Blacksell SD, Newton PN, Day NP, , 2008. Simple, rapid and sensitive detection of Orientia tsutsugamushi by loop-isothermal DNA amplification. Trans R Soc Trop Med Hyg 102: 12391246.[Crossref]
  35. Blacksell SD, Jenjaroen K, Phetsouvanh R, Wuthiekanun V, Day NP, Newton PN, Ching WM, , 2010. Accuracy of AccessBio immunoglobulin M and total antibody rapid immunochromatographic assays for the diagnosis of acute scrub typhus infection. Clin Vaccine Immunol 17: 263266.[Crossref]
  36. Blacksell SD, Jenjaroen K, Phetsouvanh R, Tanganuchitcharnchai A, Phouminh P, Phongmany S, Day NP, Newton PN, , 2010. Accuracy of rapid IgM-based immunochromatographic and immunoblot assays for diagnosis of acute scrub typhus and murine typhus infections in Laos. Am J Trop Med Hyg 83: 365369.[Crossref]
  37. Vallee J, Thaojaikong T, Moore CE, Phetsouvanh R, Richards AL, Souris M, Fournet F, Salem G, Gonzalez JP, Newton PN, , 2010. Contrasting spatial distribution and risk factors for past infection with scrub typhus and murine typhus in Vientiane City, Lao PDR. PLoS Negl Trop Dis 4: e909.[Crossref]
  38. Lee N, Ip M, Wong B, Lui G, Tsang OT, Lai JY, Choi KW, Lam R, Ng TK, Ho J, Chan YY, Cockram CS, Lai ST, , 2008. Risk factors associated with life-threatening rickettsial infections. Am J Trop Med Hyg 78: 973978.
  39. Smadel JE, Ley HL, Jr Diercks FH, Traub R, Tipton VJ, Frick LP, , 1951. Immunization against scrub typhus. I. Combined living vaccine and chemoprophylaxis in volunteers. Am J Hyg 53: 317325.
  40. Wang CC, Liu SF, Liu JW, Chung YH, Su MC, Lin MC, , 2007. Acute respiratory distress syndrome in scrub typhus. Am J Trop Med Hyg 76: 11481152.
  41. Silpapojakul K, Chupuppakarn S, Yuthasompob S, Varachit B, Chaipak D, Borkerd T, Silpapojakul K, , 1991. Scrub and murine typhus in children with obscure fever in the tropics. Pediatr Infect Dis J 10: 200203.[Crossref]
  42. Jeong YJ, Kim S, Wook YD, Lee JW, Kim KI, Lee SH, , 2007. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 27: 161172.[Crossref]
  43. Silpapojakul K, Varachit B, Silpapojakul K, , 2004. Paediatric scrub typhus in Thailand: a study of 73 confirmed cases. Trans R Soc Trop Med Hyg 98: 354359.[Crossref]
  44. Ogawa M, Hagiwara T, Kishimoto T, Shiga S, Yoshida Y, Furuya Y, Kaiho I, Ito T, Nemoto H, Yamamoto N, Masukawa K, , 2002. Scrub typhus in Japan: epidemiology and clinical features of cases reported in 1998. Am J Trop Med Hyg 67: 162165.
  45. Allen AC, Spitz S, , 1945. A comparative study of the pathology of scrub typhus (Tsutsugamushi disease) and other rickettsial diseases. Am J Pathol 21: 603681.
  46. Elisberg BL, Campbell JM, Bozeman FM, , 1968. Antigenic diversity of Rickettsia tsutsugamushi: epidemiologic and ecologic significance. J Hyg Epidemiol Microbiol Immunol 12: 1825.
  47. Tay ST, Rohani YM, Ho TM, Shamala D, , 2005. Sequence analysis of the hypervariable regions of the 56 kDa immunodominant protein genes of Orientia tsutsugamushi strains in Malaysia. Microbiol Immunol 49: 6771.[Crossref]
  48. Irons EN, , 1946. Clinical and laboratory variation of virulence in scrub typhus. Am J Trop Med Hyg 26: 165174.
  49. Shirai A, Montrey RD, Werner RM, Arimbalam S, Huxsoll DL, , 1979. Clinical responses of silvered leaf monkeys to infection with selected strains of Rickettsia tsutsugamushi . J Infect Dis 140: 811814.[Crossref]
  50. Kim YS, Lee HJ, Chang M, Son SK, Rhee YE, Shim SK, , 2006. Scrub typhus during pregnancy and its treatment: a case series and review of the literature. Am J Trop Med Hyg 75: 955959.
  51. Blacksell SD, Bryant NJ, Paris DH, Doust JA, Sakoda Y, Day NP, , 2007. Scrub typhus serologic testing with the indirect immunofluorescence method as a diagnostic gold standard: a lack of consensus leads to a lot of confusion. Clin Infect Dis 44: 391401.[Crossref]
  52. Koh GCKW, Maude RJ, Paris DH, Newton PN, Blacksell SD, , 2010. Diagnosis of scrub yyphus. Am J Trop Med Hyg 82: 368370.[Crossref]
  53. Lee YS, Wang PH, Tseng SJ, Ko CF, Teng HJ, , 2006. Epidemiology of scrub typhus in eastern Taiwan, 2000–2004. Jpn J Infect Dis 59: 235238.
  54. Saisongkorh W, Chenchittikul M, Silpapojakul K, , 2004. Evaluation of nested PCR for the diagnosis of scrub typhus among patients with acute pyrexia of unknown origin. Trans R Soc Trop Med Hyg 98: 360366.[Crossref]
  55. Walsh DS, Myint KS, Kantipong P, Jongsakul K, Watt G, , 2001. Orientia tsutsugamushi in peripheral white blood cells of patients with acute scrub typhus. Am J Trop Med Hyg 65: 899901.
  56. Furuya Y, Yoshida Y, Katayama T, Yamamoto S, Kawamura A, Jr, 1993. Serotype-specific amplification of Rickettsia tsutsugamushi DNA by nested polymerase chain reaction. J Clin Microbiol 31: 16371640.
  57. Horinouchi H, Murai K, Okayama A, Nagatomo Y, Tachibana N, Tsubouchi H, , 1996. Genotypic identification of Rickettsia tsutsugamushi by restriction fragment length polymorphism analysis of DNA amplified by the polymerase chain reaction. Am J Trop Med Hyg 54: 647651.
  58. Paris DH, Blacksell SD, Nawtaisong P, Jenjaroen K, Teeraratkul A, Chierakul W, Wuthiekanun V, Kantipong P, Day NP, , 2011. Diagnostic accuracy of a loop-mediated isothermal PCR assay for detection of Orientia tsutsugamushi during acute scrub typhus infection. PLoS Negl Trop Dis 5: e1307.[Crossref]
  59. Kundin WD, Liu C, Harmon P, Rodina P, , 1964. Pathogenesis of scrub typhus infection (Rickettsia tsutsugamushi) as studied by immunofluorescence. J Immunol 93: 772781.
  60. Groves MG, Osterman JV, , 1978. Host defenses in experimental scrub typhus: genetics of natural resistance to infection. Infect Immun 19: 583588.
  61. Sunyakumthorn P, Paris DH, Chan T-C, Jones M, Luce-Fedrow A, Chattopadhya S, Jiang J, Anantatat T, Turner GDH, Day NPJ, Richards AL, , 2013. An intradermal inoculation model of scrub typhus in Swiss CD-1 mice demonstrates more rapid dissemination of virulent strains of Orientia tsutsugamushi . PLoS One 8: e54570.[Crossref]
  62. Heisey GB, Gan E, Shirai A, Groves MG, , 1981. Scrub typhus antibody in cynomolgus monkeys (Macaca fascicularis) in Malaysia. Lab Anim Sci 31: 289291.
  63. MacMillan JG, Rice RM, Jerrells TR, , 1985. Development of antigen-specific cell-mediated immune responses after infection of cynomolgus monkeys (Macaca fascicularis) with Rickettsia tsutsugamushi . J Infect Dis 152: 739749.[Crossref]
  64. Shirai A, Montrey RD, Werner RM, Arimbalam S, Huxsoll DL, , 1979. Comparison of experimental Rickettsia tsutsugamushi infections in silvered leaf (Presbytis cristatus) and cynomolgus (Macaca fascicularis) monkeys. Jpn J Med Sci Biol 32: 345351.[Crossref]
  65. Robinson DM, Chan TC, Huxsoll DL, , 1976. Clinical response of silvered leaf monkeys (Presbytis cristatus) to infection with strains of Rickettsia tsutsugamushi virulent and avirulent for mice. J Infect Dis 134: 193197.[Crossref]
  66. Walsh DS, Delacruz EC, Abalos RM, Tan EV, Jiang J, Richards AL, Eamsila C, Rodkvantook W, Myint KS, , 2007. Clinical and histological features of inoculation site skin lesions in cynomolgus monkeys experimentally infected with Orientia tsutsugamushi . Vector Borne Zoonotic Dis 7: 547554.[Crossref]
  67. Tullis J, Gersh I, Jenny E, McLimans WF, Vinson JW, , 1947. Tissue pathology of experimental Tsutsugamushi disease (scrub typhus) in Swiss mice and macacus rhesus monkeys and the report of one human case acquired in the laboratory. Am J Trop Med Hyg 27: 245269.
  68. Paris DH, Phetsouvanh R, Tanganuchitcharnchai A, Jones M, Jenjaroen K, Vongsouvath M, Ferguson DP, Blacksell SD, Newton PN, Day NP, Turner GD, , 2012. Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium. PLoS Negl Trop Dis 6: e1466.[Crossref]
  69. Paris DH, Jenjaroen K, Blacksell SD, Phetsouvanh R, Wuthiekanun V, Newton PN, Day NP, Turner GD, , 2008. Differential patterns of endothelial and leucocyte activation in ‘typhus-like’ illnesses in Laos and Thailand. Clin Exp Immunol 153: 6367.[Crossref]
  70. Moron CG, Popov VL, Feng HM, Wear D, Walker DH, , 2001. Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus. Mod Pathol 14: 752759.[Crossref]
  71. Ge Y, Rikihisa Y, , 2011. Subversion of host cell signaling by Orientia tsutsugamushi . Microbes Infect 13: 638648.[Crossref]
  72. Smadel JE, Ley HL, Jr Diercks RH, Cameron JA, , 1952. Persistence of Rickettsia tsutsugamushi in tissues of patients recovered from scrub typhus. Am J Hyg 56: 294302.
  73. Chung MH, Lee JS, Baek JH, Kim M, Kang JS, , 2012. Persistence of Orientia tsutsugamushi in humans. J Korean Med Sci 27: 231235.[Crossref]
  74. Fox JP, , 1948. The long persistence of Rickettsia orientalis in the blood and tissues of infected animals. J Immunol 59: 109114.
  75. Shirai A, Saunders JP, Dohany AL, Huxsoll DL, Groves MG, , 1982. Transmission of scrub typhus to human volunteers by laboratory-reared chiggers. Jpn J Med Sci Biol 35: 916.[Crossref]
  76. Shirai A, Saunders JP, Dohany AL, Huxsoll DL, Groves MG, , 1982. Transmission of scrub typhus to human volunteers by laboratory-reared chiggers. Jpn J Med Sci Biol 35: 3946.
  77. Shirai A, Catanzaro PJ, Phillips SM, Osterman JV, , 1976. Host defenses in experimental scrub typhus: role of cellular immunity in heterologous protection. Infect Immun 14: 3946.
  78. Rikihisa Y, Ito S, , 1983. Effect of antibody on entry of Rickettsia tsutsugamushi into polymorphonuclear leukocyte cytoplasm. Infect Immun 39: 928938.
  79. Nacy CA, Osterman JV, , 1979. Host defenses in experimental scrub typhus: role of normal and activated macrophages. Infect Immun 26: 744750.
  80. Robinson DM, Huxsoll DL, , 1975. Protection against scrub typhus infection engendered by the passive transfer of immune sera. Southeast Asian J Trop Med Public Health 6: 477482.
  81. Seong SY, Huh MS, Jang WJ, Park SG, Kim JG, Woo SG, Choi MS, Kim IS, Chang WH, , 1997. Induction of homologous immune response to Rickettsia tsutsugamushi Boryong with a partial 56-kilodalton recombinant antigen fused with the maltose-binding protein MBP-Bor56. Infect Immun 65: 15411545.
  82. Saunders JP, Brown GW, Shirai A, Huxsoll DL, , 1980. The longevity of antibody to Rickettsia tsutsugamushi in patients with confirmed scrub typhus. Trans R Soc Trop Med Hyg 74: 253257.[Crossref]
  83. Jerrells TR, Osterman JV, , 1982. Host defenses in experimental scrub typhus: delayed-type hypersensitivity responses of inbred mice. Infect Immun 35: 117123.
  84. Palmer BA, Hetrick FM, Jerrells TJ, , 1984. Production of gamma interferon in mice immune to Rickettsia tsutsugamushi . Infect Immun 43: 5965.
  85. Palmer BA, Hetrick FM, Jerrells TR, , 1984. Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with Rickettsia tsutsugamushi . Infect Immun 46: 237244.
  86. Park S, Hwang KJ, Chu H, Park SH, Shim SK, Choi YS, Kim JS, Park MY, , 2010. Inhibition of Orientia tsutsugamushi infection by a truncated recombinant 56 kDa outer membrane protein. Lett Appl Microbiol 50: 445451.[Crossref]
  87. Chierakul W, de Fost M, Suputtamongkol Y, Limpaiboon R, Dondorp A, White NJ, van der Poll T, , 2004. Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clin Immunol 113: 140144.[Crossref]
  88. de Fost M, Chierakul W, Pimda K, Dondorp AM, White NJ, Van der Poll T, , 2005. Activation of cytotoxic lymphocytes in patients with scrub typhus. Am J Trop Med Hyg 72: 465467.
  89. Kramme S, An le V, Khoa ND, Trin le V, Tannich E, Rybniker J, Fleischer B, Drosten C, Panning M, , 2009. Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients. J Clin Microbiol 47: 586589.[Crossref]
  90. Chung DR, Lee YS, Lee SS, , 2008. Kinetics of inflammatory cytokines in patients with scrub typhus receiving doxycycline treatment. J Infect 56: 4450.[Crossref]
  91. Iwasaki H, Mizoguchi J, Takada N, Tai K, Ikegaya S, Ueda T, , 2010. Correlation between the concentrations of tumor necrosis factor-alpha and the severity of disease in patients infected with Orientia tsutsugamushi . Int J Infect Dis 14: e328e333.[Crossref]
  92. Paris DH, Chansamouth V, Nawtaisong P, Löwenberg EC, Phetsouvanh R, Blacksell SD, Lee SJ, Dondorp AM, van der Poll T, Newton PN, Levi M, Day NP, , 2012. Coagulation and inflammation in scrub typhus and murine typhus—a prospective comparative study from Laos. Clin Microbiol Infect 18: 12211228.[Crossref]
  93. Eisenberg GH, Jr Osterman JV, , 1978. Effects of temperature on the stability of Rickettsia tsutsugamushi and gamma-irradiated scrub typhus immunogens. Infect Immun 22: 298300.
  94. Eisenberg GH, Jr Osterman JV, , 1978. Gamma-irradiated scrub typhus immunogens: development and duration of immunity. Infect Immun 22: 8086.
  95. Valbuena G, Walker DH, , 2012. Approaches to vaccines against Orientia tsutsugamushi . Front Cell Infect Microbiol 2: 170.
  96. Choi Y, Kim KS, Kim TY, Cheong HS, Ahn BY, , 2006. Long-term egg-yolk adaptation of the Orientia tsutsugamushi for preparation of a formalinized immunogen. Vaccine 24: 14381445.[Crossref]
  97. Ha NY, Cho NH, Kim YS, Choi MS, Kim IS, , 2011. An autotransporter protein from Orientia tsutsugamushi mediates adherence to nonphagocytic host cells. Infect Immun 79: 17181727.[Crossref]
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  • Received : 01 Feb 2013
  • Accepted : 13 Apr 2013

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