1921
Volume 90, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

There is still no well-established consensus about the clinical management of hydatidosis. Currently, surgery continues to be the first therapeutic option, although treatment with anti-parasitic drugs is indicated as an adjuvant to surgery to decrease the number of relapses and hydatid cyst size. When surgery is not possible, medical treatment is indicated. Traditionally, albendazole was used in monotherapy as the standard treatment. However, combined therapy with albendazole plus praziquantel appears to improve anti-parasitic effectiveness. To date, no safety studies focusing on such combined therapy have been published for the treatment of hydatidosis. In this work, we analyze the adverse effects seen in 57 patients diagnosed with hydatidosis who were treated with praziquantel plus albendazole combined therapy between 2006 and 2010.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.13-0059
2014-05-07
2019-01-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/90/5/819.html?itemId=/content/journals/10.4269/ajtmh.13-0059&mimeType=html&fmt=ahah

References

  1. Budke CM, Deplazes P, Torgerson PR, , 2006. Global socioeconomic impact of cystic echinococcosis. Emerg Infect Dis 12: 296303.[Crossref] [Google Scholar]
  2. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L, , 2007. Control of neglected tropical diseases. N Engl J Med 357: 10181027.[Crossref] [Google Scholar]
  3. Seimenis A, , 2003. Overview of the epidemiological situation on echinococcosis in the Mediterranean region. Acta Trop 85: 191195.[Crossref] [Google Scholar]
  4. Sotiraki S, Himonas C, Korkoliakou P, , 2003. Hydatidosis-echinococcosis in Greece. Acta Trop 85: 197201.[Crossref] [Google Scholar]
  5. Lorenzini R, Ruggieri A, , 1987. Distribution of echinococcosis/hydatidosis in Italy. J Helminthol 61: 261267.[Crossref] [Google Scholar]
  6. Rojo-Vazquez FA, Pardo-Lledias J, Francos-Von Hunefeld M, Cordero-Sanchez M, Alamo-Sanz R, Hernandez-Gonzalez A, Brunetti E, Siles-Lucas M, , 2011. Cystic echinococcosis in Spain: current situation and relevance for other endemic areas in Europe. PLoS Negl Trop Dis 5: e893.[Crossref] [Google Scholar]
  7. Pardo J, Muro A, Galindo I, Cordero M, Carpio A, Siles-Lucas M, , 2005. Hydatidosis in the province of Salamanca (Spain): should we let down our guard? Enferm Infecc Microbiol Clin 23: 266269.[Crossref] [Google Scholar]
  8. Vuitton DA, , 2009. Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus? Expert Rev Anti Infect Ther 7: 145149.[Crossref] [Google Scholar]
  9. WHO, 1996. Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis. Bull World Health Organ 74: 231242. [Google Scholar]
  10. Menezes da Silva A, , 2003. Hydatid cyst of the liver-criteria for the selection of appropriate treatment. Acta Trop 85: 237242.[Crossref] [Google Scholar]
  11. Smego RA, Jr Sebanego P, , 2005. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 9: 6976.[Crossref] [Google Scholar]
  12. Silva MA, Mirza DF, Bramhall SR, Mayer AD, McMaster P, Buckels JA, , 2004. Treatment of hydatid disease of the liver. Evaluation of a UK experience. Dig Surg 21: 227233, discussion 233–234.[Crossref] [Google Scholar]
  13. Pelaez V, Kugler C, Correa D, Del Carpio M, Guangiroli M, Molina J, Marcos B, Lopez E, , 2000. PAIR as percutaneous treatment of hydatid liver cysts. Acta Trop 75: 197202.[Crossref] [Google Scholar]
  14. Ustunsoz B, Akhan O, Kamiloglu MA, Somuncu I, Ugurel MS, Cetiner S, , 1999. Percutaneous treatment of hydatid cysts of the liver: long-term results. AJR Am J Roentgenol 172: 9196.[Crossref] [Google Scholar]
  15. Filice C, Brunetti E, Bruno R, Crippa FG, , 2000. Percutaneous drainage of echinococcal cysts (PAIR–puncture, aspiration, injection, reaspiration): results of a worldwide survey for assessment of its safety and efficacy. WHO-Informal Working Group on Echinococcosis-Pair Network. Gut 47: 156157.[Crossref] [Google Scholar]
  16. Perez-Molina JA, Diaz-Menendez M, Gallego JI, Norman F, Monge-Maillo B, Ayala AP, Lopez-Velez R, , 2011. Evaluation of nitazoxanide for the treatment of disseminated cystic echinococcosis: report of five cases and literature review. Am J Trop Med Hyg 84: 351356.[Crossref] [Google Scholar]
  17. Mohamed AE, Yasawy MI, Al Karawi MA, , 1998. Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology 45: 16901694. [Google Scholar]
  18. Yasawy MI, al Karawi MA, Mohamed AR, , 1993. Combination of praziquantel and albendazole in the treatment of hydatid disease. Trop Med Parasitol 44: 192194. [Google Scholar]
  19. El-On J, , 2003. Benzimidazole treatment of cystic echinococcosis. Acta Trop 85: 243252.[Crossref] [Google Scholar]
  20. Falagas ME, Bliziotis IA, , 2007. Albendazole for the treatment of human echinococcosis: a review of comparative clinical trials. Am J Med Sci 334: 171179.[Crossref] [Google Scholar]
  21. Stojkovic M, Zwahlen M, Teggi A, Vutova K, Cretu CM, Virdone R, Nicolaidou P, Cobanoglu N, Junghanss T, , 2009. Treatment response of cystic echinococcosis to benzimidazoles: a systematic review. PLoS Negl Trop Dis 3: e524.[Crossref] [Google Scholar]
  22. Horton RJ, , 1997. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop 64: 7993.[Crossref] [Google Scholar]
  23. Cobo F, Yarnoz C, Sesma B, Fraile P, Aizcorbe M, Trujillo R, Diaz-de-Liano A, Ciga MA, , 1998. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by Echinococcus granulosus . Trop Med Int Health 3: 462466.[Crossref] [Google Scholar]
  24. Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A, Roilides E, Giannoulis E, , 2008. Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol 21: 429435.[Crossref] [Google Scholar]
  25. Jamshidi M, Mohraz M, Zangeneh M, Jamshidi A, , 2008. The effect of combination therapy with albendazole and praziquantel on hydatid cyst treatment. Parasitol Res 103: 195199.[Crossref] [Google Scholar]
  26. Salto E, Juarez E, Roiz MP, Abad J, , 1991. Combined chemotherapy (mebendazole plus praziquantel) in patients with hydatidosis. Enferm Infecc Microbiol Clin 9: 527529. [Google Scholar]
  27. Jevtic M, Mikic D, Arsic-Komljenovic G, Stankovic N, Ristanovic E, Sjenicic G, Janicijevic-Hudomal S, , 2008. Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease. Vojnosanit Pregl 65: 539544.[Crossref] [Google Scholar]
  28. Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, , 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603605. [Google Scholar]
  29. el-Hawey AM, Massoud AM, el-Rakieby A, Rozeik MS, Nassar MO, , 1990. Side effects of praziquantel in bilharzial children on a field level. J Egypt Soc Parasitol 20: 599605. [Google Scholar]
  30. Lima RM, Ferreira MA, de Jesus Ponte Carvalho TM, Dumet Fernandes BJ, Takayanagui OM, Garcia HH, Coelho EB, Lanchote VL, , 2011. Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity. Br J Clin Pharmacol 71: 528535.[Crossref] [Google Scholar]
  31. Namwanje H, Kabatereine N, Olsen A, , 2011. A randomized controlled clinical trial on the safety of co-administration of albendazole, ivermectin and praziquantel in infected schoolchildren in Uganda. Trans R Soc Trop Med Hyg 105: 181188.[Crossref] [Google Scholar]
  32. Kaur S, Singhi P, Singhi S, Khandelwal N, , 2009. Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J 28: 403406.[Crossref] [Google Scholar]
  33. Mohammed KA, Haji HJ, Gabrielli AF, Mubila L, Biswas G, Chitsulo L, Bradley MH, Engels D, Savioli L, Molyneux DH, , 2008. Triple co-administration of ivermectin, albendazole and praziquantel in Zanzibar: a safety study. PLoS Negl Trop Dis 2: e171.[Crossref] [Google Scholar]
  34. WHO, 2003. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop 85: 253261.[Crossref] [Google Scholar]
  35. Witassek F, Burkhardt B, Eckert J, Bircher J, , 1981. Chemotherapy of alveolar echinococcosis. Comparison of plasma mebendazole concentrations in animals and man. Eur J Clin Pharmacol 20: 427433.[Crossref] [Google Scholar]
  36. Morris DL, Taylor DH, , 1988. Optimal timing of post-operative albendazole prophylaxis in E. granulosus . Ann Trop Med Parasitol 82: 6566.[Crossref] [Google Scholar]
  37. Gollackner B, Langle F, Auer H, Maier A, Mittlbock M, Agstner I, Karner J, Langer F, Aspock H, Loidolt H, Rockenschaub S, Steininger R, , 2000. Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J Surg 24: 717721.[Crossref] [Google Scholar]
  38. Gavidia CM, Gonzalez AE, Barron EA, Ninaquispe B, Llamosas M, Verastegui MR, Robinson C, Gilman RH, , 2010. Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4: e616.[Crossref] [Google Scholar]
  39. Morris DL, Richards KS, Clarkson MJ, Taylor DH, , 1990. Comparison of albendazole and praziquantel therapy of Echinococcus granulosus in naturally infected sheep. Vet Parasitol 36: 8390.[Crossref] [Google Scholar]
  40. Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A, Roilides E, Giannoulis E, , 2008. Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol 21: 429435.[Crossref] [Google Scholar]
  41. el Hawey AM, Massoud AM, el Rakieby A, Rozeik MS, Nassar MO, , 1990. Side effects of praziquantel in bilharzial children on a field level. J Egypt Soc Parasitol 20: 599605. [Google Scholar]
  42. Jaoko WG, Muchemi G, Oguya FO, , 1996. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 73: 499501. [Google Scholar]
  43. Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, , 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603605. [Google Scholar]
  44. Jaoko WG, Muchemi G, Oguya FO, , 1996. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 73: 499501. [Google Scholar]
  45. Alvela-Suarez L, Novo-Veleiro I, Belhassen-Garcia M, Velasco-Tirado V, Jimenez-Cabrera S, Iglesias-Gomez A, Cordero-Sanchez M, , 2011. Dysgeusia as an adverse reaction to praziquantel. Drug Chem Toxicol 35: 116117.[Crossref] [Google Scholar]
  46. Winning A, Braslins P, McCarthy JS, , 2009. Case report: nitazoxanide for treatment of refractory bony hydatid disease. Am J Trop Med Hyg 80: 176178. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.13-0059
Loading
/content/journals/10.4269/ajtmh.13-0059
Loading

Data & Media loading...

  • Received : 28 Jan 2013
  • Accepted : 17 Dec 2013

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error