Volume 89, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Recent studies of malaria in mice show that high blood-stage parasitemia levels inhibit the development of subsequent liver-stage infections. Whether a similar inhibitory effect on liver-stage by blood-stage infection occurs in humans is unknown. We have analyzed data from a treatment-time-to-infection cohort of children < 10 years of age residing in a malaria holoendemic area of Kenya where people experience a new blood-stage infection approximately every 2 weeks. We hypothesized that if high parasitemia blocked the liver stage, then high levels of parasitemia should be followed by a “skipped” peak of parasitemia. Statistical analysis of “natural infection” field data and stochastic simulation of infection dynamics show that the data are consistent with high parasitemia inhibiting liver-stage parasite development in humans.


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  • Received : 24 Jan 2013
  • Accepted : 11 Jul 2013
  • Published online : 06 Nov 2013

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