1921
Volume 89, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Previously, we have shown that persons with human immunodeficiency virus 1 (HIV-1) infection and reduced CD4 T-lymphocyte counts excrete significantly fewer eggs than HIV-1–negative persons with similar intensities of schistosome infections. To determine how antiretroviral therapy (ART) might affect egg excretion, we conducted a study of HIV+ adults living in an area highly endemic for as they began an ART program. Fecal egg excretion and CD4 T-lymphocyte counts were evaluated at enrollment as well as 2 and 4 weeks after initiation of ART. Fourteen individuals who were Kato–Katz-negative at enrollment subsequently started excreting eggs accompanied by a significant increase in CD4 T lymphocytes ( = 0.004). Study participants who were egg-positive at enrollment and received both praziquantel and ART also showed significantly increased CD4 T-lymphocyte counts compared with baseline ( < 0.0001). Our data support a role for CD4 T lymphocytes in egg excretion.

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  • Received : 23 Jan 2013
  • Accepted : 03 Apr 2013
  • Published online : 10 Jul 2013
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