Volume 91, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenase–deficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of malaria.


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  1. Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E, , 2009. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 42: 267278.[Crossref]
  2. Santana MS, de Lacerda MV, Barbosa MG, Alecrim WD, Alecrim MG, , 2009. Glucose-6-phosphate dehydrogenase deficiency in an endemic area for malaria in Manaus: a cross-sectional survey in the Brazilian Amazon. PLoS ONE 4: e5259.[Crossref]
  3. Santana MS, Monteiro WM, Siqueira AM, Costa MF, Sampaio V, Lacerda MV, Alecrim MG, , 2013. Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon. Trans R Soc Trop Med Hyg 107: 301306.[Crossref]
  4. Brazilian Ministry of Health, 2011. Surveillance of Risk and Protective Factors for Chronic Diseases through Telephone Survey. Information about Diabetes. Available at: http://portalsaude.saude.gov.br/portalsaude/arquivos/pdf/2012/Mai/09/Vigitel_2011_diabetes_final.pdf. Accessed December 20, 2011.
  5. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC, , 2010. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J 24: 14971505.[Crossref]
  6. Price MD, Cockburn B, , 2001. Glucose-6-phosphate dehydrogenase activity in diabetes in Trinidad and Tobago. West Indian Med J 50: 3435.
  7. World Health Organization, 2006. Definition and Diagnosis of Diabetes Melittus and Intermediate Hyperglycaemia. Available at: http://www.who.int/diabetes/publications/Definition%20and%20diagnosis%20of%20diabetes_new.pdf. Accessed December 20, 2011.
  8. Chanmugam D, Frumin AM, , 1964. Abnormal oral glucose tolerance response in erythrocyte glucose-6-phosphate dehydrogenase deficiency. N Engl J Med 271: 12021204.[Crossref]
  9. Niazi GA, , 1991. Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus. Int J Hematol 54: 295298.
  10. Cappai G, Songini M, Doria A, Cavallerano JD, Lorenzi M, , 2011. Increased prevalence of proliferative retinopathy in patients with type 1 diabetes who are deficient in glucose-6-phosphate dehydrogenase. Diabetologia 54: 15391542.[Crossref]
  11. Meloni T, Pacifico A, Forteleoni G, Meloni GF, , 1992. G6PD deficiency and diabetes mellitus in northern Sardinian subjects. Haematologica 77: 9495.
  12. Vinzio S, Andres E, Perrin AE, Schlienger JL, Goichot B, , 2004. Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency. Diabetes Res Clin Pract 64: 181183.[Crossref]

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  • Received : 17 Jan 2013
  • Accepted : 13 Mar 2014

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