1921
Volume 89, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Post-treatment soil-transmitted helminth re-infection patterns were studied as part of a randomized controlled trial among school-aged children from an ethnic minority group in Yunnan province, People's Republic of China. Children with a soil-transmitted helminth infection ( = 194) were randomly assigned to triple-dose albendazole or placebo and their infection status monitored over a 6-month period using the Kato-Katz and Baermann techniques. Baseline prevalence of , , hookworm, and were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half of the participants harboring triple-species infections. For the intervention group ( = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and 19.6% for hookworm, , and , respectively. Egg reduction rates were above 88% for all three species. Rapid re-infection with was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and was considerably slower.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.13-0009
2013-07-10
2017-06-29
Loading full text...

Full text loading...

/deliver/fulltext/14761645/89/1/23.html?itemId=/content/journals/10.4269/ajtmh.13-0009&mimeType=html&fmt=ahah

References

  1. Brooker S, , 2010. Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers: a review. Int J Parasitol 40: 11371144.[Crossref]
  2. Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabè E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT-A, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA, 3rd Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Lèon FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, AlMazroa MA, Memish ZA, , 2012. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380: 21972223.[Crossref]
  3. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Ehrlich Sachs E, Sachs JD, Savioli L, , 2007. Control of neglected tropical diseases. N Engl J Med 357: 10181027.[Crossref]
  4. Utzinger J, Becker SL, Knopp S, Blum J, Neumayr AL, Keiser J, Hatz CF, , 2012. Neglected tropical diseases: diagnosis, clinical management, treatment and control. Swiss Med Wkly 142: w13727.
  5. Cox FEG, , 2002. History of human parasitology. Clin Microbiol Rev 15: 595612.[Crossref]
  6. Brooker S, Clements ACA, Bundy DAP, , 2006. Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv Parasitol 62: 221261.[Crossref]
  7. Hotez PJ, Bundy DAP, Beegle K, Brooker S, Drake L, de Silva N, Montresor A, Engels D, Jukes M, Chitsulo L, Chow J, Laxminarayan R, Michaud C, Bethony J, Correa-Oliveira R, Xiao SH, Fenwick A, Savioli L, Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P, , 2006. Helminth infections: soil-transmitted helminth infections and schistosomiasis. In: Disease Control Priorities in Developing Countries. 2nd ed. , Washington, DC: World Bank.
  8. Crompton DWT, Nesheim MC, , 2002. Nutritional impact of intestinal helminthiasis during the human life cycle. Annu Rev Nutr 22: 3559.[Crossref]
  9. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J, , 2008. Helminth infections: the great neglected tropical diseases. J Clin Invest 118: 13111321.[Crossref]
  10. Nga TT, Winichagoon P, Dijkhuizen MA, Khan NC, Wasantwisut E, Wieringa FT, , 2011. Decreased parasite load and improved cognitive outcomes caused by deworming and consumption of multi-micronutrient fortified biscuits in rural Vietnamese schoolchildren. Am J Trop Med Hyg 85: 333340.[Crossref]
  11. Yap P, Du ZW, Chen R, Zhang LP, Wu FW, Wang J, Wang XZ, Zhou H, Zhou XN, Utzinger J, Steinmann P, , 2012. Soil-transmitted helminth infections and physical fitness in school-aged Bulang children in southwest China: results from a cross-sectional survey. Parasit Vectors 5: 50.[Crossref]
  12. WHO, 2006. Preventive Chemotherapy in Human Helminthiasis: Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers. Geneva: World Health Organization.
  13. WHO, 2012. Eliminating Soil-Transmitted Helminthiases as a Public Health Problem in Children. Geneva: World Health Organization.
  14. Prichard RK, Basáñez MG, Boatin BA, McCarthy JS, Garcia HH, Yang GJ, Sripa B, Lustigman S, , 2012. A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis 6: e1549.[Crossref]
  15. Keiser J, Utzinger J, , 2008. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 19371948.[Crossref]
  16. Jia TW, Melville S, Utzinger J, King CH, Zhou XN, , 2012. Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis. PLoS Negl Trop Dis 6: e1621.[Crossref]
  17. Gabrielli AF, Montresor A, Chitsulo L, Engels D, Savioli L, , 2011. Preventive chemotherapy in human helminthiasis: theoretical and operational aspects. Trans R Soc Trop Med Hyg 105: 683693.[Crossref]
  18. Taylor-Robinson DC, Maayan N, Soares-Weiser K, Donegan S, Garner P, , 2012. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, hemoglobin and school performance. Cochrane Database Syst Rev 11: CD000371.
  19. Humphries D, Nguyen S, Boakye D, Wilson M, Cappello M, , 2012. The promise and pitfalls of mass drug administration to control intestinal helminth infections. Curr Opin Infect Dis 25: 584589.[Crossref]
  20. Steinmann P, Du ZW, Wang LB, Wang XZ, Jiang JY, Li LH, Marti H, Zhou XN, Utzinger J, , 2008. Extensive multiparasitism in a village of Yunnan province, People's Republic of China, revealed by a suite of diagnostic methods. Am J Trop Med Hyg 78: 760769.
  21. Steinmann P, Zhou XN, Du ZW, Jiang JY, Xiao SH, Wu ZX, Zhou H, Utzinger J, , 2008. Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial. PLoS Negl Trop Dis 2: e322.[Crossref]
  22. Ziegelbauer K, Steinmann P, Zhou H, Du ZW, Jiang JY, Fürst T, Jia TW, Zhou XN, Utzinger J, , 2010. Self-rated quality of life and school performance in relation to helminth infections: case study from Yunnan, People's Republic of China. Parasit Vectors 3: 61.[Crossref]
  23. Eng J, , 2003. Sample size estimation: how many individuals should be studied? Radiology 227: 309313.[Crossref]
  24. Kang M, Ragan BG, Park JH, , 2008. Issues in outcomes research: an overview of randomization techniques for clinical trials. J Athl Train 43: 215221.[Crossref]
  25. R Development Core Team, 2010. R: A Language and Environment for Statistical Analysis. Vienna: R Development Core Team.
  26. Yap P, Fürst T, Müller I, Kriemler S, Utzinger J, Steinmann P, , 2012. Determining soil-transmitted helminth infection status and physical fitness of school-aged children. J Vis Exp 66: 3966.
  27. Montresor A, Crompton DWT, Hall A, Bundy DAP, , 1998. Guidelines for the Evaluation of Soil-Transmitted Helminthiasis and Schistosomiasis at Community Level. Geneva: World Health Organization.
  28. Danso-Appiah A, Garner P, Olliaro PL, Utzinger J, , 2009. Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review. Parasitology 136: 18371849.[Crossref]
  29. Schulz KF, Altman DG, Moher D, , 2010. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. BMJ 340: c332.[Crossref]
  30. Coordinating Office of the National Survey on the Important Human Parasitic Diseases, 2005. A national survey on current status of the important parasitic diseases in human population. Chin J Parasitol Parasit Dis 23: 332340 (in Chinese).
  31. Balen J, Raso G, Li YS, Zhao ZY, Yuan LP, Williams GM, Luo XS, Shi MZ, Yu XL, Utzinger J, McManus DP, , 2011. Risk factors for helminth infections in a rural and a peri-urban setting of the Dongting Lake area, People's Republic of China. Int J Parasitol 41: 11651173.[Crossref]
  32. Shang Y, Tang LH, Zhou SS, Chen YD, Yang YC, Lin SX, , 2010. Stunting and soil-transmitted-helminth infections among school-age pupils in rural areas of southern China. Parasit Vectors 3: 97.[Crossref]
  33. Mofid LS, Bickle Q, Jiang JY, Du ZW, Patrick E, , 2011. Soil-transmitted helminthiasis in rural south-west China: prevalence, intensity and risk factor analysis. Southeast Asian J Trop Med Public Health 42: 513526.
  34. Steinmann P, Utzinger J, Du ZW, Jiang JY, Chen JX, Hattendorf J, Zhou H, Zhou XN, , 2011. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One 6: e25003.[Crossref]
  35. Hotez PJ, , 2012. Engaging a rising China through neglected tropical diseases. PLoS Negl Trop Dis 6: e1599.[Crossref]
  36. Utzinger J, Bergquist R, Olveda R, Zhou XN, , 2010. Important helminth infections in Southeast Asia: diversity, potential for control and prospects for elimination. Adv Parasitol 72: 130.[Crossref]
  37. Hotez PJ, Ehrenberg JP, , 2010. Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region. Adv Parasitol 72: 3153.[Crossref]
  38. Albonico M, Smith PG, Ercole E, Hall A, Chwaya HM, Alawi KS, Savioli L, , 1995. Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area. Trans R Soc Trop Med Hyg 89: 538541.[Crossref]
  39. Saathoff E, Olsen A, Kvalsvig JD, Appleton CC, , 2004. Patterns of geohelminth infection, impact of albendazole treatment and re-infection after treatment in schoolchildren from rural KwaZulu-Natal/South-Africa. BMC Infect Dis 4: 27.[Crossref]
  40. Vercruysse J, Behnke JM, Albonico M, Ame SM, Angebault C, Bethony JM, Engels D, Guillard B, Nguyen TV, Kang G, Kattula D, Kotze AC, McCarthy JS, Mekonnen Z, Montresor A, Periago MV, Sumo L, Tchuem Tchuenté LA, Dang TC, Zeynudin A, Levecke B, , 2011. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis 5: e948.[Crossref]
  41. Namwanje H, Kabatereine NB, Olsen A, , 2011. Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. Trans R Soc Trop Med Hyg 105: 586590.[Crossref]
  42. Speich B, Ame SM, Ali SM, Alles R, Hattendorf J, Utzinger J, Albonico M, Keiser J, , 2012. Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial. PLoS Negl Trop Dis 6: e1685.[Crossref]
  43. Geary TG, , 2012. Are new anthelmintics needed to eliminate human helminthiases? Curr Opin Infect Dis 25: 709717.[Crossref]
  44. Montresor A, , 2011. Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis. Trans R Soc Trop Med Hyg 105: 361363.[Crossref]
  45. Keiser J, Utzinger J, , 2010. The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 73: 197230.[Crossref]
  46. Geary TG, Woo K, McCarthy JS, Mackenzie CD, Horton J, Prichard RK, de Silva NR, Olliaro PL, Lazdins-Helds JK, Engels DA, Bundy DA, , 2010. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40: 113.[Crossref]
  47. CDC, 2013. Hookworm: Biology. Available at: http://www.cdc.gov/parasites/hookworm/biology.html. Accessed February 21, 2013.
  48. Steinmann P, Zhou XN, Du ZW, Jiang JY, Wang LB, Wang XZ, Li LH, Marti H, Utzinger J, , 2007. Occurrence of Strongyloides stercoralis in Yunnan province, China, and comparison of diagnostic methods. PLoS Negl Trop Dis 1: e75.[Crossref]
  49. Becker SL, Sieto B, Silué KD, Adjossan L, Koné S, Hatz C, Kern WV, N'Goran EK, Utzinger J, , 2011. Diagnosis, clinical features, and self-reported morbidity of Strongyloides stercoralis and hookworm infection in a co-endemic setting. PLoS Negl Trop Dis 5: e1292.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.13-0009
Loading
/content/journals/10.4269/ajtmh.13-0009
Loading

Data & Media loading...

Supplementary Data

Supplementary PDF

  • Received : 07 Jan 2013
  • Accepted : 27 Mar 2013

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error