Volume 90, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Opportunistic diseases cause substantial morbidity and mortality to human immunodeficiency virus (HIV)-infected patients. Highly active antiretroviral therapy (HAART) leading to immune reconstitution is the most effective treatment of preventing opportunistic diseases. This retrospective study established an epidemiologic profile of opportunistic diseases 10 years after the introduction of HAART. The HIV antiretroviral therapy-naive patients matching inclusion criteria were included. The primary outcome was the prevalence of opportunistic diseases. From January 1, 2002 to September 30, 2010, 654 opportunistic diseases were identified in 458 patients. Pulmonary tuberculosis, herpes zoster, cerebral toxoplasmosis, oral candidiasis, and severe pneumonia accounted for 22.05%, 15.94%, 14.19%, 14.19%, and 9.39%, respectively. Cryptococcal meningitis and pneumocystosis accounted for 0.44% and 0.21%, respectively. The prevalence of opportunistic diseases in Gabon remains high. New guidelines emphasize the importance of initiating antiretroviral therapy early to reconstitute the immune system, and reduce disease risk, and treat the primary opportunistic infection of pulmonary tuberculosis.


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  1. UNAIDS, 2010. Global Report: UNAIDS Report on the Global AIDS Epidemic 2010. Available at: http://data.unaids.org/pub/Report/2009/JC1700_Epi_Update_2009_en.pdf. Accessed July 8, 2011.
  2. Zolopa A, Andersen J, Powderly W, Sanchez A, Sanne I, Suckow C, Hogg E, Komarow L, , 2009. Early antiretroviral therapy reduces AIDS progression/death in individuals with acute opportunistic infections: a multicenter randomized strategy trial. PLoS ONE 4: e5575.[Crossref]
  3. Okome-Nkoumou M, Mbounja-Loclo ME, Kombila M, , 2000. Spectrum of opportunistic infections in subjects infected with HIV at Libreville, Gabon. Sante 10: 329337.
  4. Okome-Nkoumou M, Boguikouma JB, Kombila M, , 2006. Opportunistic diseases in HIV-infected patients at the Jeanne Ebori Foundation in Libreville, Gabon. Med Trop 66: 167171.
  5. CDC, Epi Info. Available at: http://wwwn.cdc.gov/epiinfo/. Accessed February 15, 2012.
  6. Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C, , 2003. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 163: 10091021.[Crossref]
  7. Oumar AA, Diallo S, Kaba MK, Cisse IA, Tounkara A, , 2008. Prevalence des infections opportunistes au cours du SIDA en milieu hospitalier de Bamako, Mali. Louv Med 127: 1217.
  8. Gordon MA, Graham SM, Walsh AL, Wilson L, Phiri A, Molyneux E, Zijlstra EE, Heyderman RS, Hart CA, Molyneux ME, , 2008. Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi. Clin Infect Dis 46: 963969.[Crossref]
  9. Jarvis JN, Harrison TS, , 2007. HIV-associated cryptococcal meningitis. AIDS 21: 21192129.[Crossref]
  10. Garcia-Hermoso D, Janbon G, Dromer F, , 1999. Epidemiological evidence for dormant Cryptococcus neoformans infection. J Clin Microbiol 37: 32043209.
  11. Grant AD, Djomand G, Smets P, Kadio A, Coulibaly M, Kakou A, Maurice C, Whitaker JP, Sylla-Koko F, Bonard D, Wiktor SZ, Hayes RJ, De Cock KM, Greenberg AE, , 1997. Profound immunosuppression across the spectrum of opportunistic disease among hospitalized HIV-infected adults in Abidjan, Cote d'Ivoire. AIDS 11: 13571364.[Crossref]
  12. Lundgren JD, Melbye M, Pedersen C, Rosenberg PS, Gerstoft J, , 1995. Changing patterns of Kaposi's sarcoma in Danish acquired immunodeficiency syndrome patients with complete follow-up. The Danish Study Group for HIV Infection (DASHI). Am J Epidemiol 141: 652658.[Crossref]
  13. Peters BS, Beck EJ, Coleman DG, Wadsworth MJ, Mcguinness O, Harris JR, Pinching AJ, , 1991. Changing disease patterns in patients with AIDS in a referral centre in the United Kingdom: the changing face of AIDS. BMJ 302: 203207.[Crossref]
  14. Lifson AR, Darrow WW, Hessol NA, O'Malley PM, Barnhart JL, Jaffe HW, Rutherford GW, , 1990. Kaposi's sarcoma in a cohort of homosexual and bisexual men. Epidemiology and analysis for cofactors. Am J Epidemiol 131: 221231.[Crossref]

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  • Received : 26 Dec 2012
  • Accepted : 06 Oct 2013

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