Volume 88, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We studied the value of an IgG Western blot (WB) with (Pk) antigen for diagnosis of North American paragonimiasis. The test was evaluated with sera from patients with Pk and infections, with control sera from patients with other helminth infections, and sera from healthy Americans. All 11 proven Pk infection sera and two samples from suspected cases that were negative by WB at the Centers for Disease Control and Prevention (CDC) contained antibodies to antigens at 34 kDa and at 21/23 kDa. Seven of 7 sera contained antibodies to the 34 kDa antigen, but only 2 recognized the 21/23 kDa doublet. No control samples were reactive with these antigens. Antibody reactivity declined after praziquantel treatment. Thus, the WB appears to be superior to WB for diagnosing Pk infections, and it may be useful for assessing responses to treatment.


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  • Received : 30 Nov 2012
  • Accepted : 16 Jan 2013
  • Published online : 05 Jun 2013

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