1921
Volume 89, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The aim of this translational study was to show the use of molecular surveillance for polymorphisms and copy number as a monitoring tool to track the emergence and dynamics of drug resistance. A molecular baseline for Suriname was established in 2005, with chloroquine resistance transporter () and multidrug resistance () markers and copy number in 40 samples. The baseline results revealed the existence of a uniformly distributed mutated genotype corresponding with the fully mefloquine-sensitive 7G8-like genotype (Y184F, S1034C, N1042D, and D1246Y) and a fixed N86 haplotype. All samples harbored the pivotal K76T mutation, showing that chloroquine reintroduction should not yet be contemplated in Suriname. After 5 years, 40 samples were assessed to trace temporal changes in the status of polymorphisms and copy number and showed minor genetic alterations in the gene and no significant changes in copy number, thus providing scientific support for prolongation of the current drug policy in Suriname.

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2013-08-07
2017-11-18
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  • Received : 19 Nov 2012
  • Accepted : 22 May 2013

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