1921
Volume 89, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Malaria diagnostics are widely used in epidemiologic studies to investigate natural history of disease and in drug and vaccine clinical trials to exclude participants or evaluate efficacy. The Malaria Laboratory Network (MLN), managed by the Office of HIV/AIDS Network Coordination, is an international working group with mutual interests in malaria disease and diagnosis and in human immunodeficiency virus/acquired immunodeficiency syndrome clinical trials. The MLN considered and studied the wide array of available malaria diagnostic tests for their suitability for screening trial participants and/or obtaining study endpoints for malaria clinical trials, including studies of HIV/malaria co-infection and other malaria natural history studies. The MLN provides recommendations on microscopy, rapid diagnostic tests, serologic tests, and molecular assays to guide selection of the most appropriate test(s) for specific research objectives. In addition, this report provides recommendations regarding quality management to ensure reproducibility across sites in clinical trials. Performance evaluation, quality control, and external quality assessment are critical processes that must be implemented in all clinical trials using malaria tests.

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2013-11-06
2017-11-19
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References

  1. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, Fullman N, Naghavi M, Lozano R, Lopez AD, , 2012. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379: 413431.[Crossref]
  2. World Health Organization, 2011. World Malaria Report 2011. Geneva: World Health Organization.
  3. Hartgers FC, Yazdanbakhsh M, , 2006. Co-infection of helminths and malaria: modulation of the immune responses to malaria. Parasite Immunol 28: 497506.[Crossref]
  4. Hochman S, Kim K, , 2009. The impact of HIV and malaria coinfection: what is known and suggested venues for further study. Interdiscip Perspect Infect Dis 2009: 617954.
  5. Pullan R, Brooker S, , 2008. The health impact of polyparasitism in humans: are we under-estimating the burden of parasitic diseases? Parasitology 135: 783794.[Crossref]
  6. Doolan DL, Dobano C, Baird JK, , 2009. Acquired immunity to malaria. Clin Microbiol Rev 22: 1336.[Crossref]
  7. Garcia LS, , 2010. Malaria. Clin Lab Med 30: 93129.[Crossref]
  8. Weiss GE, Traore B, Kayentao K, Ongoiba A, Doumbo S, Doumtabe D, Kone Y, Dia S, Guindo A, Traore A, Huang CY, Miura K, Mircetic M, Li S, Baughman A, Narum DL, Miller LH, Doumbo OK, Pierce SK, Crompton PD, , 2010. The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections. PLoS Pathog 6: e1000912.[Crossref]
  9. Bruce MC, Macheso A, Kelly-Hope LA, Nkhoma S, McConnachie A, Molyneux ME, , 2008. Effect of transmission setting and mixed species infections on clinical measures of malaria in Malawi. PLoS ONE 3: e2775.[Crossref]
  10. Kochar DK, Das A, Kochar A, Middha S, Acharya J, Tanwar GS, Gupta A, Pakalapati D, Garg S, Saxena V, Subudhi AK, Boopathi PA, Sirohi P, Kochar SK, , 2010. Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (northwestern India). Platelets 21: 623627.[Crossref]
  11. Flateau C, Le Loup G, Pialoux G, , 2011. Consequences of HIV infection on malaria and therapeutic implications: a systematic review. Lancet Infect Dis 11: 541556.[Crossref]
  12. Trape JF, Peelman P, Morault-Peelman B, , 1985. Criteria for diagnosing clinical malaria among a semi-immune population exposed to intense and perennial transmission. Trans R Soc Trop Med Hyg 79: 435442.[Crossref]
  13. World Health Organization, 2010. Guidelines for the Treatment of Malaria. Second edition. Geneva: World Health Organization.
  14. Roper C, Pearce R, Nair S, Sharp B, Nosten F, Anderson T, , 2004. Intercontinental spread of pyrimethamine-resistant malaria. Science 305: 1124.[Crossref]
  15. Wellems TE, Plowe CV, , 2001. Chloroquine-resistant malaria. J Infect Dis 184: 770776.[Crossref]
  16. White NJ, Pongtavornpinyo W, Maude RJ, Saralamba S, Aguas R, Stepniewska K, Lee SJ, Dondorp AM, White LJ, Day NP, , 2009. Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance. Malar J 8: 253.[Crossref]
  17. Ohrt C, Purnomo Sutamihardja MA, Tang D, Kain KC, , 2002. Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials. J Infect Dis 186: 540546.[Crossref]
  18. Van Braeckel E, Koutsoukos M, Bourguignon P, Clement F, McNally L, Leroux-Roels G, , 2011. Vaccine-induced HIV seropositivity: a problem on the rise. J Clin Virol 50: 334337.[Crossref]
  19. Cooper CJ, Metch B, Dragavon J, Coombs RW, Baden LR, , 2010. Vaccine-induced HIV seropositivity/reactivity in noninfected HIV vaccine recipients. JAMA 304: 275283.[Crossref]
  20. Makler MT, Palmer CJ, Ager AL, , 1998. A review of practical techniques for the diagnosis of malaria. Ann Trop Med Parasitol 92: 419433.[Crossref]
  21. Bruce-Chwatt LJ, , 1984. DNA probes for malaria diagnosis. Lancet 1: 795.[Crossref]
  22. Payne D, , 1988. Use and limitations of light microscopy for diagnosing malaria at the primary health care level. Bull World Health Organ 66: 621626.
  23. World Health Organization, 1988. Malaria diagnosis: memorandum from a WHO meeting. Bull World Health Organ 66: 575594.
  24. Milne LM, Kyi MS, Chiodini PL, Warhurst DC, , 1994. Accuracy of routine laboratory diagnosis of malaria in the United Kingdom. J Clin Pathol 47: 740742.[Crossref]
  25. Wongsrichanalai C, Barcus MJ, Muth S, Sutamihardja A, Wernsdorfer WH, , 2007. A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT). Am J Trop Med Hyg 77: 119127.
  26. Dowling MA, Shute GT, , 1966. A comparative study of thick and thin blood films in the diagnosis of scanty malaria parasitaemia. Bull World Health Organ 34: 249267.
  27. Laurens MB, Duncan CJ, Epstein JE, Hill AV, Komisar JL, Lyke KE, Ockenhouse CF, Richie TL, Roestenberg M, Sauerwein RW, Spring MD, Talley AK, Moorthy VS, Consensus Group on Design of Clinical Trials of Controlled Human Malaria Infection; , 2012. A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines. Vaccine 30: 53025304.[Crossref]
  28. Bejon P, Andrews L, Hunt-Cooke A, Sanderson F, Gilbert SC, Hill AV, , 2006. Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density. Malar J 5: 104.[Crossref]
  29. Murphy SC, Prentice JL, Williamson K, Wallis CK, Fang FC, Fried M, Pinzon C, Wang R, Talley AK, Kappe SH, Duffy PE, Cookson BT, , 2012. Real-time quantitative reverse transcription PCR for monitoring of blood-stage Plasmodium falciparum infections in malaria human challenge trials. Am J Trop Med Hyg 86: 383394.[Crossref]
  30. O'Meara WP, Barcus M, Wongsrichanalai C, Muth S, Maguire JD, Jordan RG, Prescott WR, McKenzie FE, , 2006. Reader technique as a source of variability in determining malaria parasite density by microscopy. Malar J 5: 118.[Crossref]
  31. Olliaro P, Djimde A, Karema C, Martensson A, Ndiaye JL, Sirima SB, Dorsey G, Zwang J, , 2011. Standardised versus actual white cell counts in estimating thick film parasitaemia in African children under five. Trop Med Int Health 16: 551554.[Crossref]
  32. World Health Organization, 2009. Malaria Microscopy Quality Assurance Manual – Version 1. Geneva: World Health Organization.
  33. Guindo MA, Shott JP, Saye R, Diakite ML, Sanogo S, Dembele MB, Keita S, Nagel MC, Ellis RD, Aebig JA, Diallo DA, Doumbo OK, , 2012. Promoting good clinical laboratory practices and laboratory accreditation to support clinical trials in sub-Saharan Africa. Am J Trop Med Hyg 86: 573579.[Crossref]
  34. Ohrt C, Obare P, Nanakorn A, Adhiambo C, Awuondo K, O'Meara WP, Remich S, Martin K, Cook E, Chretien JP, Lucas C, Osoga J, McEvoy P, Owaga ML, Odera JS, Ogutu B, , 2007. Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya. Malar J 6: 79.[Crossref]
  35. Jordan R, Torrez M, Mico M, , 2010. Improving malaria diagnosis in Equatorial Guinea. Rural 21: 41543.
  36. Kiggundu M, Nsobya SL, Kamya MR, Filler S, Nasr S, Dorsey G, Yeka A, , 2011. Evaluation of a comprehensive refresher training program in malaria microscopy covering four districts of Uganda. Am J Trop Med Hyg 84: 820824.[Crossref]
  37. Prescott WR, Jordan RG, Grobusch MP, Chinchilli VM, Kleinschmidt I, Borovsky J, Plaskow M, Torres M, Mico M, Schwabe C, , 2012. Performance of a malaria microscopy image analysis slide reading device. Malar J 11: 155.[Crossref]
  38. Purwar Y, Shah SL, Clarke G, Almugairi A, Muehlenbachs A, , 2011. Automated and unsupervised detection of malarial parasites in microscopic images. Malar J 10: 364.[Crossref]
  39. Tek FB, Dempster AG, Kale I, , 2009. Computer vision for microscopy diagnosis of malaria. Malar J 8: 153.[Crossref]
  40. World Health Organization; Foundation for Innovative New Diagnostics, TDR, 2012. RDT Evaluation Programme. Available at: http://www2.wpro.who.int/sites/rdt/who_rdt_evaluation. Accessed October 24, 2012.
  41. Marquart L, Butterworth A, McCarthy JS, Gatton ML, , 2012. Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance. Malar J 11: 74.[Crossref]
  42. Gamboa D, Ho MF, Bendezu J, Torres K, Chiodini PL, Barnwell JW, Incardona S, Perkins M, Bell D, McCarthy J, Cheng Q, , 2010. A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests. PLoS ONE 5: e8091.[Crossref]
  43. Koita OA, Doumbo OK, Ouattara A, Tall LK, Konare A, Diakite M, Diallo M, Sagara I, Masinde GL, Doumbo SN, Dolo A, Tounkara A, Traore I, Krogstad DJ, , 2012. False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene. Am J Trop Med Hyg 86: 194198.[Crossref]
  44. Iqbal J, Siddique A, Jameel M, Hira PR, , 2004. Persistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection. J Clin Microbiol 42: 42374241.[Crossref]
  45. Tjitra E, Suprianto S, McBroom J, Currie BJ, Anstey NM, , 2001. Persistent ICT malaria P.f/P.v panmalarial and HRP2 antigen reactivity after treatment of Plasmodium falciparum malaria is associated with gametocytemia and results in false-positive diagnoses of Plasmodium vivax in convalescence. J Clin Microbiol 39: 10251031.[Crossref]
  46. Kattenberg JH, Tahita CM, Versteeg IA, Tinto H, Traore-Coulibaly M, Schallig HD, Mens PF, , 2012. Antigen persistence of rapid diagnostic tests in pregnant women in Nanoro, Burkina Faso, and the implications for the diagnosis of malaria in pregnancy. Trop Med Int Health 17: 550557.[Crossref]
  47. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G, , 2008. Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis 197: 510518.[Crossref]
  48. Chinkhumba J, Skarbinski J, Chilima B, Campbell C, Ewing V, San Joaquin M, Sande J, Ali D, Mathanga D, , 2010. Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi. Malar J 9: 209.
  49. McMorrow ML, Masanja MI, Kahigwa E, Abdulla SM, Kachur SP, , 2010. Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania. Am J Trop Med Hyg 82: 151155.[Crossref]
  50. Aidoo M, Patel JC, Barnwell JW, , 2012. Dried Plasmodium falciparum-infected samples as positive controls for malaria rapid diagnostic tests. Malar J 11: 239.[Crossref]
  51. Iqbal J, Khalid N, Hira PR, , 2003. Performance of rapid malaria Pf antigen test for the diagnosis of malaria and false-reactivity with autoantibodies. Adv Exp Med Biol 531: 135148.[Crossref]
  52. Iqbal J, Sher A, Rab A, , 2000. Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors. J Clin Microbiol 38: 11841186.
  53. Gillet P, Scheirlinck A, Stokx J, De Weggheleire A, Chauque HS, Canhanga OD, Tadeu BT, Mosse CD, Tiago A, Mabunda S, Bruggeman C, Bottieau E, Jacobs J, , 2011. Prozone in malaria rapid diagnostics tests: how many cases are missed? Malar J 10: 166.[Crossref]
  54. World Health Organization, 2010. Malaria Rapid Diagnostic Test Performance: Summary Results of WHO Product Testing of Malaria RDTs: Rounds 1 and 2 (2008–2009). Diseases WHOOBOTSPFRaTIT. Geneva: World Health Organization.
  55. Fried M, Duffy PE, , 1996. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science 272: 15021504.[Crossref]
  56. Adegnika AA, Kohler C, Agnandji ST, Chai SK, Labuda L, Breitling LP, Schonkeren D, Weerdenburg E, Issifou S, Luty AJ, Kremsner PG, Yazdanbakhsh M, , 2008. Pregnancy-associated malaria affects toll-like receptor ligand-induced cytokine responses in cord blood. J Infect Dis 198: 928936.[Crossref]
  57. Mockenhaupt FP, Rong B, Till H, Eggelte TA, Beck S, Gyasi-Sarpong C, Thompson WN, Bienzle U, , 2000. Submicroscopic Plasmodium falciparum infections in pregnancy in Ghana. Trop Med Int Health 5: 167173.[Crossref]
  58. Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D, , 2009. Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Malar J 8: 254.[Crossref]
  59. World Health Organization, 2004. A Strategic Framework for Malaria Prevention and Control during Pregnancy in the African Region. Brazzaville, Republic of Congo: World Health Organization.
  60. Badaut C, Bertin G, Rustico T, Fievet N, Massougbodji A, Gaye A, Deloron P, , 2010. Towards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6epsilon domain of VAR2CSA. PLoS ONE 5: e11276.[Crossref]
  61. Hviid L, , 2010. The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development. Hum Vaccin 6: 8489.[Crossref]
  62. Brahmbhatt H, Sullivan D, Kigozi G, Askin F, Wabwire-Mangenm F, Serwadda D, Sewankambo N, Wawer M, Gray R, , 2008. Association of HIV and malaria with mother-to-child transmission, birth outcomes, and child mortality. J Acquir Immune Defic Syndr 47: 472476.[Crossref]
  63. Dhorda M, Piola P, Nyehangane D, Tumwebaze B, Nalusaji A, Nabasumba C, Turyakira E, McGready R, Ashley E, Guerin PJ, Snounou G, , 2012. Performance of a histidine-rich protein 2 rapid diagnostic test, Paracheck Pf(R), for detection of malaria infections in Ugandan pregnant women. Am J Trop Med Hyg 86: 9395.[Crossref]
  64. Kattenberg JH, Ochodo EA, Boer KR, Schallig HD, Mens PF, Leeflang MM, , 2011. Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women. Malar J 10: 321.[Crossref]
  65. Kyabayinze DJ, Tibenderana JK, Nassali M, Tumwine LK, Riches C, Montague M, Counihan H, Hamade P, Van Geertruyden JP, Meek S, , 2011. Placental Plasmodium falciparum malaria infection: operational accuracy of HRP2 rapid diagnostic tests in a malaria endemic setting. Malar J 10: 306.[Crossref]
  66. Tagbor H, Bruce J, Browne E, Greenwood B, Chandramohan D, , 2008. Performance of the OptiMAL dipstick in the diagnosis of malaria infection in pregnancy. Ther Clin Risk Manag 4: 631636.[Crossref]
  67. Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H, , 2008. Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. Malar J 7: 221.[Crossref]
  68. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR, , 2012. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med 367: 21102118.[Crossref]
  69. Mills LA, Kagaayi J, Nakigozi G, Galiwango RM, Ouma J, Shott JP, Ssempijja V, Gray RH, Wawer MJ, Serwadda D, Quinn TC, Reynolds SJ, , 2010. Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda. Am J Trop Med Hyg 82: 145147.[Crossref]
  70. Ssekabira U, Bukirwa H, Hopkins H, Namagembe A, Weaver MR, Sebuyira LM, Quick L, Staedke S, Yeka A, Kiggundu M, Schneider G, McAdam K, Wabwire-Mangen F, Dorsey G, , 2008. Improved malaria case management after integrated team-based training of health care workers in Uganda. Am J Trop Med Hyg 79: 826833.
  71. McMorrow ML, Aidoo M, Kachur SP, , 2011. Malaria rapid diagnostic tests in elimination settings: can they find the last parasite? Clin Microbiol Infect 17: 16241631.[Crossref]
  72. Ciceron L, Jaureguiberry G, Gay F, Danis M, , 1999. Development of a Plasmodium PCR for monitoring efficacy of antimalarial treatment. J Clin Microbiol 37: 3538.
  73. Coleman RE, Sattabongkot J, Promstaporm S, Maneechai N, Tippayachai B, Kengluecha A, Rachapaew N, Zollner G, Miller RS, Vaughan JA, Thimasarn K, Khuntirat B, , 2006. Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand. Malar J 5: 121.[Crossref]
  74. Das A, Holloway B, Collins WE, Shama VP, Ghosh SK, Sinha S, Hasnain SE, Talwar GP, Lal AA, , 1995. Species-specific 18S rRNA gene amplification for the detection of P. falciparum and P. vivax malaria parasites. Mol Cell Probes 9: 161165.[Crossref]
  75. Han ET, Watanabe R, Sattabongkot J, Khuntirat B, Sirichaisinthop J, Iriko H, Jin L, Takeo S, Tsuboi T, , 2007. Detection of four Plasmodium species by genus- and species-specific loop-mediated isothermal amplification for clinical diagnosis. J Clin Microbiol 45: 25212528.[Crossref]
  76. Kho WG, Chung JY, Sim EJ, Kim MY, Kim DW, Jongwutiwes S, Tanabe K, , 2003. A multiplex polymerase chain reaction for a differential diagnosis of Plasmodium falciparum and Plasmodium vivax . Parasitol Int 52: 229236.[Crossref]
  77. Mangold KA, Manson RU, Koay ES, Stephens L, Regner M, Thomson RB, Jr Peterson LR, Kaul KL, , 2005. Real-time PCR for detection and identification of Plasmodium spp. J Clin Microbiol 43: 24352440.[Crossref]
  78. Mens PF, Schoone GJ, Kager PA, Schallig HD, , 2006. Detection and identification of human Plasmodium species with real-time quantitative nucleic acid sequence-based amplification. Malar J 5: 80.[Crossref]
  79. Mixson-Hayden T, Lucchi NW, Udhayakumar V, , 2010. Evaluation of three PCR-based diagnostic assays for detecting mixed Plasmodium infection. BMC Res Notes 3: 88.[Crossref]
  80. Perandin F, Manca N, Calderaro A, Piccolo G, Galati L, Ricci L, Medici MC, Arcangeletti MC, Snounou G, Dettori G, Chezzi C, , 2004. Development of a real-time PCR assay for detection of Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale for routine clinical diagnosis. J Clin Microbiol 42: 12141219.[Crossref]
  81. Rougemont M, Van Saanen M, Sahli R, Hinrikson HP, Bille J, Jaton K, , 2004. Detection of four Plasmodium species in blood from humans by 18S rRNA gene subunit-based and species-specific real-time PCR assays. J Clin Microbiol 42: 56365643.[Crossref]
  82. Safeukui I, Millet P, Boucher S, Melinard L, Fregeville F, Receveur MC, Pistone T, Fialon P, Vincendeau P, Fleury H, Malvy D, , 2008. Evaluation of FRET real-time PCR assay for rapid detection and differentiation of Plasmodium species in returning travellers and migrants. Malar J 7: 70.[Crossref]
  83. Schneider P, Wolters L, Schoone G, Schallig H, Sillekens P, Hermsen R, Sauerwein R, , 2005. Real-time nucleic acid sequence-based amplification is more convenient than real-time PCR for quantification of Plasmodium falciparum . J Clin Microbiol 43: 402405.[Crossref]
  84. Schoone GJ, Oskam L, Kroon NC, Schallig HD, Omar SA, , 2000. Detection and quantification of Plasmodium falciparum in blood samples using quantitative nucleic acid sequence-based amplification. J Clin Microbiol 38: 40724075.
  85. Singh B, Bobogare A, Cox-Singh J, Snounou G, Abdullah MS, Rahman HA, , 1999. A genus- and species-specific nested polymerase chain reaction malaria detection assay for epidemiologic studies. Am J Trop Med Hyg 60: 687692.
  86. Singh B, Kim Sung L, Matusop A, Radhakrishnan A, Shamsul SS, Cox-Singh J, Thomas A, Conway DJ, , 2004. A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 363: 10171024.[Crossref]
  87. Snounou G, Singh B, , 2002. Nested PCR analysis of Plasmodium parasites. Methods Mol Med 72: 189203.
  88. Snounou G, , 2002. Genotyping of Plasmodium spp. Nested PCR. Methods Mol Med 72: 103116.
  89. Swan H, Sloan L, Muyombwe A, Chavalitshewinkoon-Petmitr P, Krudsood S, Leowattana W, Wilairatana P, Looareesuwan S, Rosenblatt J, , 2005. Evaluation of a real-time polymerase chain reaction assay for the diagnosis of malaria in patients from Thailand. Am J Trop Med Hyg 73: 850854.
  90. Tangin A, Komichi Y, Wagatsuma Y, Rashidul H, Wataya Y, Kim HS, , 2008. Detection of malaria parasites in mosquitoes from the malaria-endemic area of Chakaria, Bangladesh. Biol Pharm Bull 31: 703708.[Crossref]
  91. Vo TK, Bigot P, Gazin P, Sinou V, De Pina JJ, Huynh DC, Fumoux F, Parzy D, , 2007. Evaluation of a real-time PCR assay for malaria diagnosis in patients from Vietnam and in returned travellers. Trans R Soc Trop Med Hyg 101: 422428.[Crossref]
  92. Bachmann LH, Desmond RA, Stephens J, Hughes A, Hook EW, 3rd, 2002. Duration of persistence of gonococcal DNA detected by ligase chain reaction in men and women following recommended therapy for uncomplicated gonorrhea. J Clin Microbiol 40: 35963601.[Crossref]
  93. Johnson RE, Newhall WJ, Papp JR, Knapp JS, Black CM, Gift TL, Steece R, Markowitz LE, Devine OJ, Walsh CM, Wang S, Gunter DC, Irwin KL, Delisle S, Berman SM, , 2002. Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections—2002. MMWR Recomm Rep 51: 138.
  94. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G, , 2004. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis 189: 22202226.[Crossref]
  95. Robinson T, Campino SG, Auburn S, Assefa SA, Polley SD, Manske M, Macinnis B, Rockett KA, Maslen GL, Sanders M, Quail MA, Chiodini PL, Kwiatkowski DP, Clark TG, Sutherland CJ, , 2011. Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients. PLoS ONE 6: e23204.[Crossref]
  96. Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G, , 2003. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg 68: 133139.
  97. Daniels R, Ndiaye D, Wall M, McKinney J, Sene PD, Sabeti PC, Volkman SK, Mboup S, Wirth DF, , 2012. Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum . Antimicrob Agents Chemother 56: 29762986.[Crossref]
  98. Gunderson JH, Sogin ML, Wollett G, Hollingdale M, De La Cruz VF, Waters AP, McCutchan TF, , 1987. Structurally distinct, stage-specific ribosomes occur in Plasmodium . Science 238: 933937.[Crossref]
  99. Oguike MC, Betson M, Burke M, Nolder D, Stothard JR, Kleinschmidt I, Proietti C, Bousema T, Ndounga M, Tanabe K, Ntege E, Culleton R, Sutherland CJ, , 2011. Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities. Int J Parasitol 41: 677683.[Crossref]
  100. Sutherland CJ, Tanomsing N, Nolder D, Oguike M, Jennison C, Pukrittayakamee S, Dolecek C, Hien TT, Do Rosario VE, Arez AP, Pinto J, Michon P, Escalante AA, Nosten F, Burke M, Lee R, Blaze M, Otto TD, Barnwell JW, Pain A, Williams J, White NJ, Day NP, Snounou G, Lockhart PJ, Chiodini PL, Imwong M, Polley SD, , 2010. Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. J Infect Dis 201: 15441550.[Crossref]
  101. Hermsen CC, Telgt DS, Linders EH, Van De Locht LA, Eling WM, Mensink EJ, Sauerwein RW, , 2001. Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR. Mol Biochem Parasitol 118: 247251.[Crossref]
  102. Murphy SC, Daza G, Chang M, Coombs R, , 2012. Laser cutting eliminates nucleic acid cross-contamination in dried blood spot processing. J Clin Microbiol 50: 41284130.[Crossref]
  103. Buppan P, Putaporntip C, Pattanawong U, Seethamchai S, Jongwutiwes S, , 2010. Comparative detection of Plasmodium vivax and Plasmodium falciparum DNA in saliva and urine samples from symptomatic malaria patients in a low endemic area. Malar J 9: 72.[Crossref]
  104. Mharakurwa S, Simoloka C, Thuma PE, Shiff CJ, Sullivan DJ, , 2006. PCR detection of Plasmodium falciparum in human urine and saliva samples. Malar J 5: 103.[Crossref]
  105. Putaporntip C, Buppan P, Jongwutiwes S, , 2011. Improved performance with saliva and urine as alternative DNA sources for malaria diagnosis by mitochondrial DNA-based PCR assays. Clin Microbiol Infect 17: 14841491.[Crossref]
  106. Lamikanra AA, Dobano C, Jimenez A, Nhabomba A, Tsang HP, Guinovart C, Manaca MN, Quinto L, Aguilar R, Cistero P, Alonso PL, Roberts DJ, Mayor A, , 2012. A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children. Malar J 11: 201.[Crossref]
  107. Bharti AR, Letendre SL, Patra KP, Vinetz JM, Smith DM, , 2009. Malaria diagnosis by a polymerase chain reaction-based assay using a pooling strategy. Am J Trop Med Hyg 81: 754757.[Crossref]
  108. Al-Soud WA, Radstrom P, , 2001. Purification and characterization of PCR-inhibitory components in blood cells. J Clin Microbiol 39: 485493.[Crossref]
  109. Westgard JO, Barry PL, Hunt MR, Groth T, , 1981. A multi-rule Shewhart chart for quality control in clinical chemistry. Clin Chem 27: 493501.
  110. Mayor A, Moro L, Aguilar R, Bardaji A, Cistero P, Serra-Casas E, Sigauque B, Alonso PL, Ordi J, Menendez C, , 2012. How hidden can malaria be in pregnant women? Diagnosis by microscopy, placental histology, polymerase chain reaction and detection of histidine-rich protein 2 in plasma. Clin Infect Dis 54: 15611568.[Crossref]
  111. Epstein JE, Rao S, Williams F, Freilich D, Luke T, Sedegah M, De La Vega P, Sacci J, Richie TL, Hoffman SL, , 2007. Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update. J Infect Dis 196: 145154.[Crossref]
  112. Sauerwein RW, Roestenberg M, Moorthy VS, , 2011. Experimental human challenge infections can accelerate clinical malaria vaccine development. Nat Rev Immunol 11: 5764.[Crossref]
  113. Andrews L, Andersen RF, Webster D, Dunachie S, Walther RM, Bejon P, Hunt-Cooke A, Bergson G, Sanderson F, Hill AV, Gilbert SC, , 2005. Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials. Am J Trop Med Hyg 73: 191198.
  114. Hermsen CC, De Vlas SJ, Van Gemert GJ, Telgt DS, Verhage DF, Sauerwein RW, , 2004. Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction. Am J Trop Med Hyg 71: 196201.
  115. Bejon P, Andrews L, Andersen RF, Dunachie S, Webster D, Walther M, Gilbert SC, Peto T, Hill AV, , 2005. Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites. J Infect Dis 191: 619626.[Crossref]
  116. Kuamsab N, Putaporntip C, Pattanawong U, Jongwutiwes S, , 2012. Simultaneous detection of Plasmodium vivax and Plasmodium falciparum gametocytes in clinical isolates by multiplex-nested RT-PCR. Malar J 11: 190.[Crossref]
  117. Lima NF, Bastos MS, Ferreira MU, , 2012. Plasmodium vivax: reverse transcriptase real-time PCR for gametocyte detection and quantitation in clinical samples. Exp Parasitol 132: 348354.[Crossref]
  118. Wargo AR, Randle N, Chan BH, Thompson J, Read AF, Babiker HA, , 2006. Plasmodium chabaudi: reverse transcription PCR for the detection and quantification of transmission stage malaria parasites. Exp Parasitol 112: 1320.[Crossref]
  119. Drame PM, Poinsignon A, Besnard P, Cornelie S, Le Mire J, Toto JC, Foumane V, Dos-Santos MA, Sembene M, Fortes F, Simondon F, Carnevale P, Remoue F, , 2010. Human antibody responses to the Anopheles salivary gSG6-P1 peptide: a novel tool for evaluating the efficacy of ITNs in malaria vector control. PLoS ONE 5: e15596.[Crossref]
  120. Poinsignon A, Cornelie S, Mestres-Simon M, Lanfrancotti A, Rossignol M, Boulanger D, Cisse B, Sokhna C, Arca B, Simondon F, Remoue F, , 2008. Novel peptide marker corresponding to salivary protein gSG6 potentially identifies exposure to Anopheles bites. PLoS ONE 3: e2472.[Crossref]
  121. Dodoo D, Aikins A, Kusi KA, Lamptey H, Remarque E, Milligan P, Bosomprah S, Chilengi R, Osei YD, Akanmori BD, Theisen M, , 2008. Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children. Malar J 7: 142.[Crossref]
  122. Hopkins H, Gonzalez IJ, Polley SD, Angutoko P, Ategeka J, Asiimwe C, Agaba B, Kyabayinze DJ, Sutherland CJ, Perkins MD, Bell D, , 2013. Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J Infect Dis 208: 645652.[Crossref]
  123. Surabattula R, Vejandla MP, Mallepaddi PC, Faulstich K, Polavarapu R, , 2013. Simple, rapid, inexpensive platform for the diagnosis of malaria by loop mediated isothermal amplification (LAMP). Exp Parasitol 134: 333340.[Crossref]
  124. Fu E, Kauffman P, Lutz B, Yager P, , 2010. Chemical signal amplification in two-dimensional paper networks. Sens Actuators B Chem 149: 325328.[Crossref]
  125. Osborn JL, Lutz B, Fu E, Kauffman P, Stevens DY, Yager P, , 2010. Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks. Lab Chip 10: 26592665.[Crossref]
  126. Fung AO, Damoiseaux R, Grundeen S, Panes JL, Horton DH, Judy JW, Moore TB, , 2012. Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines. Malar J 11: 175.[Crossref]
  127. Hamers RL, De Beer IH, Kaura H, Van Vugt M, Caparos L, Rinke De Wit TF, , 2008. Diagnostic accuracy of 2 oral fluid-based tests for HIV surveillance in Namibia. J Acquir Immune Defic Syndr 48: 116118.[Crossref]
  128. Kagulire SC, Stamper PD, Opendi P, Nakavuma JL, Mills LA, Makumbi F, Gray RH, Serwadda D, Reynolds SJ, , 2007. Performance of two commercial immunochromatographic assays for rapid detection of antibodies specific to human immunodeficiency virus types 1 and 2 in serum and urine samples in a rural community-based research setting (Rakai, Uganda). Clin Vaccine Immunol 14: 738740.[Crossref]
  129. Pascoe SJ, Langhaug LF, Mudzori J, Burke E, Hayes R, Cowan FM, , 2009. Field evaluation of diagnostic accuracy of an oral fluid rapid test for HIV, tested at point-of-service sites in rural Zimbabwe. AIDS Patient Care STDS 23: 571576.[Crossref]
  130. Taye B, Woldeamanuel Y, Kebede E, , 2006. Diagnostic detection of human immunodeficincy virus type-1 antibodies in urine, Jimma Hospital, south west Ethiopia. Ethiop Med J 44: 363368.
  131. Boehme C, Molokova E, Minja F, Geis S, Loscher T, Maboko L, Koulchin V, Hoelscher M, , 2005. Detection of mycobacterial lipoarabinomannan with an antigen-capture ELISA in unprocessed urine of Tanzanian patients with suspected tuberculosis. Trans R Soc Trop Med Hyg 99: 893900.[Crossref]
  132. Mutetwa R, Boehme C, Dimairo M, Bandason T, Munyati SS, Mangwanya D, Mungofa S, Butterworth AE, Mason PR, Corbett EL, , 2009. Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients. Int J Tuberc Lung Dis 13: 12531259.
  133. Lucchi NW, Oberstaller J, Kissinger JC, Udhayakumar V, , 2013. Malaria diagnostics and surveillance in the post-genomic era. Public Health Genomics 16: 3743.[Crossref]
  134. Sia SK, Kricka LJ, , 2008. Microfluidics and point-of-care testing. Lab Chip 8: 19821983.[Crossref]
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  • Received : 02 Nov 2012
  • Accepted : 05 Aug 2013

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