1921
Volume 88, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Chloroquine (CQ) is officially used for the primary treatment of malaria in Honduras. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated malaria in the municipality of Puerto Lempira, Gracias a Dios, Honduras was evaluated using the Pan American Health Organization—World Health Organization protocol with a follow-up of 28 days. Sixty-eight patients from 6 months to 60 years of age microscopically diagnosed with uncomplicated malaria were included in the final analysis. All patients who were treated with CQ (25 mg/kg over 3 days) cleared parasitemia by day 3 and acquired no new infection within 28 days of follow-up. All the parasite samples sequenced for CQ resistance mutations () showed only the CQ-sensitive genotype (CVMNK). This finding shows that CQ remains highly efficacious for the treatment of uncomplicated malaria in Gracias a Dios, Honduras.

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  • Received : 31 Oct 2012
  • Accepted : 30 Nov 2012

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