1921
Volume 88, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We describe a case of hemophagocytic lymphohistiocytosis related to visceral leishmaniasis in late adulthood. Because clinical features of visceral leishmaniasis can mimic those of hemophagocytic lymphohistiocytosis, diagnosing leishmaniasis as the underlying etiology can be quite challenging. In our case, treatment with amphotericin B resulted in a dramatic resolution of clinical abnormalities.

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/content/journals/10.4269/ajtmh.12-0563
2013-03-06
2017-09-26
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References

  1. Rajagopala S, Dutta U, Chandra KS, Bhatia P, Varma N, Kochhar R, , 2008. Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis–case report and systematic review. J Infect 56: 381388.[Crossref]
  2. Tapisiz A, Belet N, Ciftci E, Ince E, Dogru U, , 2007. Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis. J Trop Pediatr 53: 359361.[Crossref]
  3. Scott RB, , 1939. Leukopenic myelosis: (section of medicine). Proc R Soc Med 32: 14291434.
  4. Freeman HR, Ramanan AV, , 2011. Review of haemophagocytic lymphohistiocytosis. Arch Dis Child 96: 688693.[Crossref]
  5. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G, , 2007. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48: 124131.[Crossref]
  6. Gagnaire MH, Galambrun C, Stephan JL, , 2000. Hemophagocytic syndrome: a misleading complication of visceral leishmaniasis in children–a series of 12 cases. Pediatrics 106: E58.[Crossref]
  7. Marom D, Offer I, Tamary H, Jaffe CL, Garty BZ, , 2001. Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis. Pediatr Hematol Oncol 18: 6570.[Crossref]
  8. Tunc B, Ayata A, , 2001. Hemophagocytic syndrome: a rare life-threatening complication of visceral leishmaniasis in a young boy. Pediatr Hematol Oncol 18: 531536.[Crossref]
  9. Carvalho SF, Lemos EM, Corey R, Dietze R, , 2003. Performance of recombinant K39 antigen in the diagnosis of Brazilian visceral leishmaniasis. Am J Trop Med Hyg 68: 321324.
  10. Larroche C, Bruneel F, Andre MH, Bader-Meunier B, Baruchel A, Tribout B, Genereau T, Zunic P, , 2000. Intravenously administered gamma-globulins in reactive hemaphagocytic syndrome. Multicenter study to assess their importance, by the immunoglobulins group of experts of CEDIT of the AP-HP. Ann Med Interne (Paris) 151: 533539.
  11. Boggs JM, Chang NH, Goundalkar A, , 1991. Liposomal amphotericin B inhibits in vitro T-lymphocyte response to antigen. Antimicrob Agents Chemother 35: 879885.[Crossref]
  12. Hauser WE, Jr Remington JS, , 1983. Effect of amphotericin B on natural killer cell activity in vitro . J Antimicrob Chemother 11: 257262.[Crossref]
  13. Kretschmar M, Geginat G, Bertsch T, Walter S, Hof H, Nichterlein T, , 2001. Influence of liposomal amphotericin B on CD8 T-cell function. Antimicrob Agents Chemother 45: 23832385.[Crossref]
  14. Mehta RT, Mehta K, Lopez-Berestein G, Juliano RL, , 1985. Effect of liposomal amphotericin B on murine macrophages and lymphocytes. Infect Immun 47: 429433.
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  • Received : 11 Sep 2012
  • Accepted : 09 Dec 2012

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