1921
Volume 88, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Severe malaria is characterized by a massive release of proinflammatory cytokines in the context of sequestration of parasitized and normal red cells (RBCs). High-mobility group box 1 (HMGB1) is a DNA- and heparin-binding protein that also acts as a cytokine when released from cells in the extracellular milieu after a proinflammatory stimulus. In this study, we have measured the circulating levels of HMGB1 in 76 children with severe or uncomplicated malaria. Sera from both severe ( = 0.0022) and uncomplicated ( = 0.0049) patients had significantly higher circulating HMGB1 levels compared with healthy controls. Elevated HMGB1 in patients with ongoing infections might prolong inflammation and the febrile state of malaria and could offer a potential target for therapeutic intervention.

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  • Received : 29 Aug 2012
  • Accepted : 30 Nov 2012
  • Published online : 03 Apr 2013

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