Volume 89, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Schistosomiasis control efforts mainly target school–aged children. We studied the epidemiology of schistosomiasis in two high-risk communities in south Côte d'Ivoire, placing particular emphasis on pre-school–aged children. We used a suite of diagnostic techniques, including Kato–Katz, urine filtration, reagent strips, and urine circulating cathodic antigen cassettes. Risk factors for schistosomiasis were determined by focus group discussions and a structured questionnaire. The prevalence of in the two study villages among the pre-school–aged children (age < 6 years) was 20.9% and 25.0%, whereas several-fold higher prevalences were found in school–aged children (58.7–68.4%) and adolescents/adults (59.5–61.7%). The prevalence of in the three age groups was 5.9–17.3%, 10.9–18.4%, and 3.8–21.3%, respectively. Most participants had light-intensity infections. Mothers' occupations and older siblings play important roles in the epidemiology of schistosomiasis in pre-schoolers. In the current epidemiologic settings, more attention is warranted on pre-school–aged children and adolescents/adults for successful schistosomiasis control.


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  1. Southgate VR, Rollinson D, Tchuem Tchuenté LA, Hagan P, , 2005. Towards control of schistosomiasis in sub-Saharan Africa. J Helminthol 79: 181185.[Crossref]
  2. Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Ehrlich Sachs S, Sachs JD, , 2006. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3: e102.[Crossref]
  3. Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J, , 2006. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis 6: 411425.[Crossref]
  4. Utzinger J, Raso G, Brooker S, de Savigny D, Tanner M, Ørnbjerg N, Singer BH, N'Goran EK, , 2009. Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution. Parasitology 136: 18591874.[Crossref]
  5. Sleigh AC, Mott KE, Hoff R, Barreto ML, Mota EA, Maguire JH, Sherlock I, Weller TH, , 1985. Three-year prospective study of the evolution of Manson's schistosomiasis in north-east Brazil. Lancet 326: 6366.[Crossref]
  6. Woolhouse MEJ, , 1998. Patterns in parasite epidemiology: the peak shift. Parasitol Today 14: 428434.[Crossref]
  7. Wilkins HA, Goll PH, Marshall TF, Moore PJ, , 1984. Dynamics of Schistosoma haematobium infection in a Gambian community. III. Acquisition and loss of infection. Trans R Soc Trop Med Hyg 78: 227232.[Crossref]
  8. Butterworth AE, Capron M, Cordingley JS, Dalton PR, Dunne DW, Kariuki HC, Kimani G, Koech D, Mugambi M, Ouma JH, Prentice MA, Richardson BA, Arap Siongok TK, Sturrock RF, Taylor DW, , 1985. Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune responses. Trans R Soc Trop Med Hyg 79: 393408.[Crossref]
  9. Verani JR, Abudho B, Montgomery SP, Mwinzi PN, Shane HL, Butler SE, Karanja DM, Secor WE, , 2011. Schistosomiasis among young children in Usoma, Kenya. Am J Trop Med Hyg 84: 787791.[Crossref]
  10. Allen HE, Crompton DWT, de Silva N, LoVerde PT, Olds GR, , 2002. New policies for using anthelmintics in high risk groups. Trends Parasitol 18: 381382.[Crossref]
  11. Geary TG, Woo K, McCarthy JS, Mackenzie CD, Horton J, Prichard RK, de Silva NR, Olliaro PL, Lazdins-Helds JK, Engels DA, Bundy DA, , 2010. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40: 113.[Crossref]
  12. Garba A, Barkire N, Djibo A, Lamine MS, Sofo B, Gouvras AN, Bosque-Oliva E, Webster JP, Stothard JR, Utzinger J, Fenwick A, , 2010. Schistosomiasis in infants and preschool-aged children: infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of Niger. Acta Trop 115: 212219.[Crossref]
  13. Bosompem KM, Bentum IA, Otchere J, Anyan WK, Brown CA, Osada Y, Takeo S, Kojima S, Ohta N, , 2004. Infant schistosomiasis in Ghana: a survey in an irrigation community. Trop Med Int Health 9: 917922.[Crossref]
  14. Dabo A, Badawi HM, Bary B, Doumbo OK, , 2011. Urinary schistosomiasis among preschool-aged children in Sahelian rural communities in Mali. Parasit Vectors 4: 21.[Crossref]
  15. N'Guessan NA, Acka CA, Utzinger J, N'Goran EK, , 2006. Identification des régions à haut risque de schistosomoses en Côte d'Ivoire. Bull Soc Pathol Exot 100: 119123.
  16. Coulibaly JT, Knopp S, N'Guessan NA, Silué KD, Fürst T, Lohourignon LK, Brou JK, N'Gbesso YK, Vounatsou P, N'Goran EK, Utzinger J, , 2011. Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire. PLoS Negl Trop Dis 5: e1384.[Crossref]
  17. Rollinson D, Knopp S, Levitz S, Stothard JR, Tchuem Tchuenté LA, Garba A, Mohammed KA, Schur N, Person B, Colley DG, Utzinger J, , 2012. Time to set the agenda for schistosomiasis elimination. Acta Trop, doi:10.1016/j.actatropica.2012.04.013.
  18. Coulibaly JT, N'Gbesso YK, Knopp S, Keiser J, N'Goran EK, Utzinger J, , 2012. Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium . PLoS Negl Trop Dis 6: e1917.[Crossref]
  19. Katz N, Chaves A, Pellegrino J, , 1972. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop São Paulo 14: 397400.
  20. Farooq M, Mallah MB, , 1966. The behavioural pattern of social and religious water-contact activities in the Egypt-49 bilharziasis project area. Bull World Health Organ 35: 377387.
  21. Siegal FM, , 1968. Schistosomiasis hematobia in preschool children of Ibadan, Nigeria. Am J Trop Med Hyg 17: 737742.
  22. Abdel-Salam E, Abdel-Fattah M, , 1977. Prevalence and morbidity of Schistosoma haematobium in Egyptian children. A controlled study. Am J Trop Med Hyg 26: 463469.
  23. Perel Y, Sellin B, Perel C, Arnold P, Mouchet F, , 1985. Use of urine collectors for infants from 0 to 4 years of age in a mass survey of urinary schistosomiasis in Niger. Med Trop 45: 429433.
  24. Smith FM, , 1985. Bilharziasis in the African infant and child in the Mtoko, southern Rhodesia. Cent Afr J Med 4: 287288.
  25. Stothard JR, Sousa-Figueiredo JC, Betson M, Green HK, Seto EYW, Garba A, Sacko M, Mutapi F, Vaz Nery S, Amin MA, Mutumba-Nakalembe M, Navaratnam A, Fenwick A, Kabatereine NB, Gabrielli AF, Montresor A, , 2011. Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children. Parasitology 138: 15931606.[Crossref]
  26. Keiser J, Ingram K, Utzinger J, , 2011. Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control. Parasitology 138: 16201632.[Crossref]
  27. Stothard JR, Gabrielli AF, , 2007. Schistosomiasis in African infants and preschool children: to treat or not to treat? Trends Parasitol 23: 8386.[Crossref]
  28. Sousa-Figueiredo JC, Basáñez MG, Mgeni AF, Khamis IS, Rollinson D, Stothard JR, , 2008. A parasitological survey, in rural Zanzibar, of pre-school children and their mothers for urinary schistosomiasis, soil-transmitted helminthiases and malaria, with observations on the prevalence of anaemia. Ann Trop Med Parasitol 102: 679692.[Crossref]
  29. Ekpo UF, Oluwole AS, Abe EM, Etta HE, Olamiju F, Mafiana CF, , 2012. Schistosomiasis in infants and pre-school-aged children in sub-Saharan Africa: implication for control. Parasitology 139: 835841.[Crossref]
  30. Johansen MV, Sacko M, Vennervald BJ, Kabatereine NB, , 2007. Leave children untreated and sustain inequity! Trends Parasitol 23: 568569.[Crossref]
  31. Sousa-Figueiredo JC, Pleasant J, Day M, Betson M, Rollinson D, Montresor A, Kazibwe F, Kabatereine NB, Stothard JR, , 2010. Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole. Int Health 2: 103113.[Crossref]
  32. Stothard JR, Sousa-Figueiredo JC, Betson M, Bustinduy A, Reinhard-Rupp J, , 2013. Schistosomiasis in African infants and preschool children: let them now be treated! Trends Parasitol 29: 197205.[Crossref]
  33. Ekpo UF, Laja-Deile A, Oluwole AS, Sam-Wobo SO, Mafiana CF, , 2010. Urinary schistosomiasis among preschool children in a rural community near Abeokuta, Nigeria. Parasit Vectors 3: 58.[Crossref]
  34. Namwanje H, Kabatereine NB, Olsen A, , 2011. The acceptability and safety of praziquantel alone and in combination with mebendazole in the treatment of Schistosoma mansoni and soil-transmitted helminthiasis in children aged 1–4 years in Uganda. Parasitology 138: 15861592.[Crossref]
  35. Hotez PJ, Engels D, Fenwick A, Savioli L, , 2010. Africa is desperate for praziquantel. Lancet 376: 496498.[Crossref]
  36. Stothard JR, Sousa-Figuereido JC, Betson M, Adriko M, Arinaitwe M, Rowell C, Besiyge F, Kabatereine NB, , 2011. Schistosoma mansoni infections in young children: when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable? PLoS Negl Trop Dis 5: e938.[Crossref]
  37. Odogwu SE, Ramamurthy NK, Kabatereine NB, Kazibwe F, Tukahebwa E, Webster JP, Fenwick A, Stothard JR, , 2006. Schistosoma mansoni in infants (aged < 3 years) along the Ugandan shoreline of Lake Victoria. Ann Trop Med Parasitol 100: 315326.[Crossref]
  38. Sabah AA, Fletcher C, Webbe G, Doenhoff MJ, , 1986. Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol 61: 294303.[Crossref]
  39. King CH, , 2010. Parasites and poverty: the case of schistosomiasis. Acta Trop 113: 95104.[Crossref]
  40. Kariuki HC, Clennon JA, Brady MS, Kitron U, Sturrock RF, Ouma JH, Ndzovu ST, Mungai P, Hoffman O, Hamburger J, Pellegrini C, Muchiri EM, King CH, , 2004. Distribution patterns and cercarial shedding of Bulinus nasutus and other snails in the Msambweni area, Coast province, Kenya. Am J Trop Med Hyg 70: 449456.
  41. Clennon JA, King CH, Muchiri EM, Kitron U, , 2007. Hydrological modeling of snail dispersal patterns in Msambweni, Kenya and potential resurgence of Schistosoma haematobium transmission. Parasitology 134: 683693.[Crossref]
  42. Tchuem Tchuenté LA, Southgate VR, Webster BL, De Bont J, Vercruysse J, , 2001. Impact of installation of a water pump on schistosomiasis transmission in a focus in Cameroon. Trans R Soc Trop Med Hyg 95: 255256.[Crossref]

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  • Received : 31 May 2012
  • Accepted : 19 Jan 2013

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