1921
Volume 88, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We investigated the effectiveness of routine preventive measures for anemia in Beninese pregnant women during pregnancy. Anemia (hemoglobin < 110 g/L) was common: 68.3% at first antenatal visit (ANV1), 64.7% at second antenatal visit (ANV2), and 40.6% at delivery. Parasitic infections and nutritional deficiencies were the most preventable causes. After intermittent preventive treatment (IPTp) and antihelminthic treatments, malaria prevalence decreased from 15.1% (ANV1) to 4.0% (ANV2) and increased again to 9.6% at delivery. Helminth infections dropped from 11.1% (ANV1) to 7.2% (ANV2) and 2.4% at delivery. Malaria was associated with lower mean hemoglobin on ANV1 and delivery, and iron deficiency was associated with lower mean hemoglobin on ANV1 and ANV2. IPTp and antihelminthic treatments were efficacious to clear parasitic infections and improve hematologic status, whereas the effectiveness of daily iron and folic acid supplements to correct iron and folate deficiencies and decrease anemia was less marked, possibly because of lack of compliance.

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References

  1. WHO, 2001. Iron Deficiency Anaemia Assessment, Prevention, and Control. A Guide for Programme Managers. Geneva, Switzerland: WHO. [Google Scholar]
  2. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B, , 2009. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr 12: 444454.[Crossref] [Google Scholar]
  3. Stoltzfus RJ, , 2003. Iron deficiency: global prevalence and consequences. Food Nutr Bull 24: S99S103.[Crossref] [Google Scholar]
  4. Bodeau-Livinec F, Briand V, Berger J, Xiong X, Massougbodji A, Day KP, Cot M, , 2011. Maternal anemia in Benin: prevalence, risk factors, and association with low birth weight. Am J Trop Med Hyg 85: 414420.[Crossref] [Google Scholar]
  5. van den Broek N, , 1998. Anaemia in pregnancy in developing countries. Br J Obstet Gynaecol 105: 385390.[Crossref] [Google Scholar]
  6. Tolentino K, Friedman JF, , 2007. An update on anemia in less developed countries. Am J Trop Med Hyg 77: 4451. [Google Scholar]
  7. Balarajan Y, Ramakrishnan U, Ozaltin E, Shankar AH, Subramanian SV, , 2011. Anaemia in low-income and middle-income countries. Lancet 378: 21232135.[Crossref] [Google Scholar]
  8. Ouédraogo S, Koura GK, Accrombessi MMK, Bodeau-Livinec F, Massougbodji A, Cot M, , 2012. Maternal anaemia at first antenatal visit: prevalence and risk factors in a malaria endemic area in Benin. Am J Trop Med Hyg, 87: 418424.[Crossref] [Google Scholar]
  9. Stephansson O, Dickman PW, Johansson A, Cnattingius S, , 2000. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA 284: 26112617.[Crossref] [Google Scholar]
  10. Xiong X, Buekens P, Fraser WD, Guo Z, , 2003. Anemia during pregnancy in a Chinese population. Int J Gynaecol Obstet 83: 159164.[Crossref] [Google Scholar]
  11. De Maeyer EM, , 1989. Preventing and Controlling Iron Deficiency Through Primary Care. Geneva, Switzerland: WHO. [Google Scholar]
  12. WHO, 2000. WHO Expert Committee on Malaria. Twentieth Report. Geneva, Switzerland: WHO. [Google Scholar]
  13. WHO, 2009. Weekly Iron-Folic Acid Supplementations (WIFS) in Women of Reproductive Age: Its Role in Promoting Optimal Maternal and Child Health Position Statement. Geneva, Switzerland: WHO. [Google Scholar]
  14. Ndibazza J, Muhangi L, Akishule D, Kiggundu M, Ameke C, Oweka J, Kizindo R, Duong T, Kleinschmidt I, Muwanga M, Elliott AM, , 2010. Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial. Clin Infect Dis 50: 531540.[Crossref] [Google Scholar]
  15. Kabyemela ER, Fried M, Kurtis JD, Mutabingwa TK, Duffy PE, , 2008. Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency. J Infect Dis 198: 163166.[Crossref] [Google Scholar]
  16. Beaton GH, , 2000. Iron needs during pregnancy: do we need to rethink our targets? Am J Clin Nutr 72: 265S271S. [Google Scholar]
  17. Milman N, , 2008. Prepartum anaemia: prevention and treatment. Ann Hematol 949: 959. [Google Scholar]
  18. Chesley LC, , 1972. Plasma and red cell volumes during pregnancy. Am J Obstet Gynecol 112: 440450.[Crossref] [Google Scholar]
  19. Hytten F, , 1985. Blood volume changes in normal pregnancy. Clin Haematol 14: 601612. [Google Scholar]
  20. Menendez C, Fleming AF, Alonso PL, , 2000. Malaria-related anaemia. Parasitol Today 16: 469476.[Crossref] [Google Scholar]
  21. Jennifer LS, Simon B, , 2010. Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review. Trop Med Int Health 15: 776795.[Crossref] [Google Scholar]
  22. Stoltzfus RJ, Dreyfuss ML, , 1998. Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. Washington, DC: International Life Sciences Institute Press. [Google Scholar]
  23. Menendez C, Bardaji A, Sigauque B, Romagosa C, Sanz S, Serra-Casas E, Macete E, Berenguera A, David C, Dobano C, Naniche D, Mayor A, Ordi J, Mandomando I, Aponte JJ, Mabunda S, Alonso PL, , 2008. A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic. PLoS One 3: e1934.[Crossref] [Google Scholar]
  24. Kayentao K, Kodio M, Newman RD, Maiga H, Doumtabe D, Ongoiba A, Coulibaly D, Keita AS, Maiga B, Mungai M, Parise ME, Doumbo O, , 2005. Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali. J Infect Dis 191: 109116.[Crossref] [Google Scholar]
  25. Tukur IU, Thacher TD, Sagay AS, Madaki JK, , 2007. A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women. Am J Trop Med Hyg 76: 10191023. [Google Scholar]
  26. ter Kuile FO, van Eijk AM, Filler SJ, , 2007. Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. JAMA 297: 26032616.[Crossref] [Google Scholar]
  27. Huynh BT, Fievet N, Gbaguidi G, Dechavanne S, Borgella S, Guezo-Mevo B, Massougbodji A, Ndam NT, Deloron P, Cot M, , 2011. Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin. Am J Trop Med Hyg 85: 214220.[Crossref] [Google Scholar]
  28. Faucher JF, Aubouy A, Adeothy A, Cottrell G, Doritchamou J, Gourmel B, Houze P, Kossou H, Amedome H, Massougbodji A, Cot M, Deloron P, , 2009. Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated Plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial. J Infect Dis 200: 5765.[Crossref] [Google Scholar]
  29. Bertin G, Briand V, Bonaventure D, Carrieu A, Massougbodji A, Cot M, Deloron P, , 2011. Molecular markers of resistance to sulphadoxine-pyrimethamine during intermittent preventive treatment of pregnant women in Benin. Malar J 10: 196.[Crossref] [Google Scholar]
  30. WHO, 1989. Preventing and Controlling Iron Deficiency Anaemia Through Primary Health Care. A Guide for Health Administrators and Programme Managers. Geneva, Switzerland: WHO. [Google Scholar]
  31. Widdowson EM, Spray CM, , 1951. Chemical development in utero . Arch Dis Child 26: 205214.[Crossref] [Google Scholar]
  32. Kuizon MD, Desnacido JA, Placon CP, Ancheta LD, Macapinlac MP, , 1983. Iron supplementation using different dose levels in prenant Phillipinois. Nutr Res 3: 257264.[Crossref] [Google Scholar]
  33. Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM, , 2003. Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial. Am J Clin Nutr 78: 145153. [Google Scholar]
  34. Milman N, Bergholt T, Eriksen L, Byg K-E, Graudal N, Pedersen P, Hertz J, , 2005. Iron prophylaxis during pregnancy—how much iron is needed? A randomised, controlled study of 20 to 80 mg ferrous iron daily to pregnant women. Acta Obstet Gynecol Scand 84: 238247.[Crossref] [Google Scholar]
  35. Menendez C, Todd J, Alonso P, Francis N, Lulat S, Ceesay S, M'boge B, Greenwood B, , 1994. The effects of iron supplementation during pregnancy, given by traditional birth attendants, on the prevalence of anaemia and malaria. Trans R Soc Trop Med Hyg 88: 590593.[Crossref] [Google Scholar]
  36. Zavaleta N, Caulfield LE, Garcia T, , 2000. Changes in iron status during pregnancy in Peruvian women receiving prenatal iron and folic acid supplements with or without zinc. Am J Clin Nutr 71: 956961. [Google Scholar]
  37. Bonnar J, Goldberg A, Smith JA, , 1969. Do pregnant women take their iron? Lancet 1: 457458.[Crossref] [Google Scholar]
  38. Habib F, Alabdin EH, Alenazy M, Nooh R, , 2009. Compliance to iron supplementation during pregnancy. J Obstet Gynaecol 29: 487492.[Crossref] [Google Scholar]
  39. Seck BC, Jackson RT, , 2008. Determinants of compliance with iron supplementation among pregnant women in Senegal. Public Health Nutr 11: 596605.[Crossref] [Google Scholar]
  40. Pena-Rosas JP, Viteri FE, , 2009. Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev 4: CD004736. [Google Scholar]
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  • Received : 27 Mar 2012
  • Accepted : 29 Jul 2012

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