| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Buruli ulcer (BU) is a severe disabling and disfiguring disease caused by Mycobacterium ulcerans. Its affects primarily children less than 15 years of age in many tropical and subtropical countries.1–3 In early or preulcerative lesions, M. ulcerans produces a lipid toxin, mycolactone, which is responsible for necrosis of the dermis, panniculus, and fascia, culminating in extensive ulcers.4 Preulcerative lesions and small ulcers may be surgically excised and closed. However, antimicrobial drug therapy is often effective for treatment of early lesions.5 Large ulcers or extensive edematous lesions generally require excision followed by skin grafting.6
The Bas-Congo Province of the Democratic Republic of Congo is endemic for BU and the disease is generally under-diagnosed in this region.7–9 In the surgical ward of the Institut Médical Evangélique Hospital at Kimpese, BU patients are regularly admitted, more than 90% are in an advanced stage of the disease. As required by the Medical Committee of Institut Médical Evangélique, all patients or their responsible relative or guardian must provide informed consent for all diagnostic and treatment procedures and publication of any or all images derived from the management of the patient, including clinical photographs that might reveal patient identity. We report the diagnostic and management difficulties in a patient with an edematous form of BU localized to the face and scalp.
A four-year-old Angolan boy from a refugee camp in Mpete, Democratic Republic of Congo, was admitted to the Institut Médical Evangélique Hospital on September 3, 2002, with facial edema that began two weeks earlier with painless swelling of the eyelids (Figure 1
). He had no history of trauma or insect bite and his temperature was normal. Various clinical features and types of treatment given over the observation period are shown in Table 1. Several antibiotic regimens were administered: oral ampicillin, and topical chloramphenicol ointment, followed by chloramphenicol and gentamicin, and chloramphenicol, gentamicin, indomethacin, and dexamethasone. Three weeks after admission, a diagnosis of M. ulcerans infection was suspected, but the results of a superficial skin biopsy proved nonspecific.
|
|
Ulceration that extended to the right eyelid and base of the nose (Figure 2) was treated by four surgical interventions, daily wound dressing, and skin grafts. In December 2002, lagophthalmos, upper eyelid ectropion, dacryocystitis, and a right periorbital active BU lesion developed after the first skin graft.
|
). The edema resolved and ulcerative lesions healed rapidly during this period.
|
).
|
Our patient was referred from an Angolan refugee clinic for edema of the face that developed spontaneously without a known history of insect bite, trauma, fever or pain.10 The differential diagnosis of edematous BU includes cutaneous cellulitis, edema from underlying osteomyelitis, systemic diseases (e.g., renal or cardiac failure), malnutrition, traumatic edema, Kaposi’s sarcoma, or lymphatic obstruction.
Our patient had been living in Bas-Congo for three years. He frequently accompanied his mother to a field near Kasi village, a well-known BU-endemic area.9,11 His parents had a fatalistic attitude, believing that the illness had a mystical origin and was the result of a bewitching, currently called "Mbasu" in Kikongo.12 Belief in a supernatural origin of BU has been reported by several investigators in other African countries.13,14 We frequently organize health education sessions to help BU patients and their families to better understand the nature of the disease.7
Although our patient was initially treated with antibiotics and anti-inflammatory agents, his lesion progressed. Exacerbation of BU under anti-inflammatory treatment has been observed in an Australian patient who was treated with corticosteroids.15
Diagnosis of BU in our patient was initially tentative because of the rarity of patients with the edematous nonulcerative form of BU, particularly diffuse edema of the face, who came to our hospital. Approximately one month after admission, a weeping erythematous preulcerative lesion appeared in the center of his forehead, from which a punch biopsy specimen (3 mm) was obtained. It is recommended that specimens for laboratory confirmation from nonulcerative forms (papules, nodules, plaques, and edematous forms) should be taken from the center of the surgically excised tissue and should include the entire thickness of infected tissue.1 Fine-needle aspiration was recently proposed as an alternative to punch biopsies because it does not require local anesthesia (Eddyani M and others, unpublished data).
Until recently, the only effective treatment of BU was surgical excision of the affected tissue.1,16 As early as 1950, an edematous form of BU on the eyelid of a four-year-old child was diagnosed in eastern Democratic Republic of Congo.3 The difficulties encountered in treating such cases and the need to be surgically conservative were emphasized.3 In the 1960s, some investigators noted healing of early lesions of BU after treatment with antibiotics.17 A number of well-documented cases of early lesions at our hospital in 1970 were treated successfully with rifampin (Meyers WM, unpublished data). The Global Buruli Ulcer Initiative has recently recommended the initial use of conservative treatment, particularly when lesions are located on the face, breast, and genitalia. The suggested approach is to treat the patient with antibiotics (rifampin and streptomycin) for eight weeks, with only debridement and dressings before surgery.16
Our patient had two surgical excisions before antibiotic treatment was initiated. Additional excisions were performed after three and eight weeks of antibiotherapy. However, in addition to surgery, the adjunctive medical treatment may have facilitated healing of our patient; the edema resolved and the ulcerative lesions healed rapidly during treatment and only limited debridements were required. For lesions involving the eye, clinicians may consider initial specific antibiotherapy for preulcerative lesions to promote early healing and to avoid ocular complications.
Edematous forms of BU and lesions on the face have been reported in different countries. However, there is little information on their frequency. During a five-year study (1997–2001) of 1,700 patients in Benin, edematous forms were found in only 0.7% of the patients, and lesions were found on the face and neck in 4.2% of children (0–14 years of age).18,19 In Bas-Congo during a six-year period (2002–2007), 16 (7.3%) of 219 patients had lesions on the face and 10 (62.5%) were edematous lesions (Phanzu D, unpublished data). Thus, edematous forms on the face may be more frequent in Bas-Congo than in Benin. These differences deserve special attention.
In conclusion, this case report demonstrates the diagnostic and management difficulties of the edematous form of BU on the face and suggests the possible benefit of specific antibiotherapy to enhance healing and limit the extent of surgical excisions. Our observations highlight the importance of this clinical presentation of BU and the need for health workers managing BU lesions of the head and neck to be aware of the special challenges these lesions present. Ophthalmologists, ear, nose, and throat specialists, and plastic surgeons should take special note. Prompt referral of suspected BU cases and the training of the staff at both the peripheral level and health professionals at regional hospitals in the early diagnosis of BU are of utmost importance. Finally, all clinicians treating BU patients should stay well informed of developments in the antimicrobial treatment of BU, an apparently fast-moving area of research.
Received June 27, 2007. Accepted for publication August 31, 2007.
Acknowledgments: We thank the staff of the Institut Médical Evangélique in Kimpese staff and the staff of the Mycobacteriology Unit of the Institute of Tropical Medicine in Antwerp for patient care and microbiologic analyses. We also thank Gaëlle Antoine for an outstanding work in preparation of the manuscript.
Financial support: This study was supported by the European Commission (International Science and Technology Cooperation Development Program), Project No. INCO-CT-2005-05-051476-BURULICO.
* Address correspondence to Françoise Portaels, Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalstraat 155, Antwerp 2000, Belgium. E-mail: portaels{at}itg.be 
Authors’ addresses: Delphin M. Phanzu, Desire B. Imposo, and Roger L. Mahema, Institut Médical Evangélique, PO Box 68, Kimpese, Bas-Congo, Democratic Republic of Congo. Anthony Ablordey, Noguchi Memorial Institute for Medical Research, PO Box 25, Legon, Ghana. Lucien Lefevre, Onze Lieve Vrouw Hospital, Moorselbaan 64, Aalst, Belgium. Patrick Suykerbuyk and Françoise Portaels, Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium. Wayne M. Meyers, Armed Forces Institute of Pathology, Washington, DC 20306.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
