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The Treatment of Hookworm Disease with Tetrachlorethylene¹

1. Fifty-nine prisoners were treated with 3 cc. of tetrachlorethylene, 30 with 2 cc., and 30 with 2.4 cc. of a 3 to 1 mixture of tetrachlorethylene and oil of chenopodium. Subsequently the prisoners were treated until all worms were removed, and the efficiency rates were calculated on the basis of the per cent of worms removed by the first treatment.

2. Tetrachlorethylene is more effective against female Necators than male Necators but the reverse is true of the species Ankylostoma.

3. Tetrachlorethylene in doses of 2 or 3 cc. is not as effective against Necators as is 2.4 cc. of a 3 to 1 mixture of this drug with oil of chenopodium, but when both Necators and Ankylostomes are considered the efficiency rate for tetrachlorethylene alone is higher.

4. Tetrachlorethylene is more effective against Ankylostomes than is carbon tetrachloride or than either of these drugs in combination with oil of chenopodium.

5. Both species considered, tetrachlorethylene is just as efficient as any drug that was tried or any combination of drugs.

6. The decreasing order of resistance to tetrachlorethylene is the same as that found by Soper to a 2 to 1 combination of carbon tetrachloride or tetrachlorethylene and oil of chenopodium, viz., female Ankylostoma, male Ankylostoma, male Necator, female Necator.

7. No fatalities and only one intoxication of significance were observed in the series of approximately 1,500 treatments with 3 cc. of tetrachlorethylene.

¹ This report is based upon experimental work conducted under the auspices and with the support of the Government of Madras, India, and the International Health Division of the Rockefeller Foundation.