AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med., s1-9(2), 1929, pp. 83-96
Copyright © 1929 by American Journal of Tropical Medicine

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weiss, C.
Right arrow Articles by Landrón, F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Weiss, C.
Right arrow Articles by Landrón, F.

Immunological Investigations on Tropical Sprue in Porto Rico1

Charles Weiss AND Francisco Landrón
From the School of Tropical Medicine of the University of Porto Rico under the auspices of Columbia University, and the Presbyterian Hospital, San Juan, Porto Rico

1. Specimens of whole blood from a series of 20 sprue patients were compared with specimens obtained from 20 miscellaneous hospital cases in their ability to inhibit the growth of various monilia. (Technique of Bull and Tao). No evidence of a specific monilicidal activity of the blood in sprue patients was found.
2. Exotoxins, together with the corresponding Michel vaccines (killed, autolyzed suspensions) were prepared from M. psilosis, M. albicans and a cryptococcus from cutaneous blastomycosis and used in skin tests on a series of 22 undoubted cases of sprue and 26 patients suffering with various medical and surgical disorders. While a majority of sprue cases gave positive reactions to the exotoxins of M. psilosis, a still larger percentage of the same series also reacted to the toxins of M. albicans and of a cryptococcus of cutaneous blastomycosis. In the controls (non-sprue patients) about one-third reacted to all three toxins. The tests with vaccines gave similar results.
3. Attempts to transmit sprue to three human subjects and to three ring-tailed monkeys (M. rhesus) by rubbing into their tongues the scrapings obtained from the inflamed tongue of a cachectic sprue patient were unsuccessful. Other attempts at producing the disease by injecting monilia into the skin of human volunteers and into the tongue and peritoneum of monkeys, were similarly negative.


1 Presented before the American Association of Immunologists, Washington, D. C., May 1, 1928.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1929 by the American Society of Tropical Medicine and Hygiene.