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The Gametocytes of Tertian Malaria and their Early Appearance in Malaria Transmitted by Anopheles Punctipennis¹

In the foregoing, the gametocytes of tertian malaria have been described as they appear stained by Wright's stain. Their relationship to the asexual forms, to one another, and their trend over a twenty-day period has been estimated. It was found that the average number of gametocytes as compared to schizonts was as 1 is to 22, and that this ratio is practically fixed from the onset of the infection to its artificial termination on or about the twentieth day. The ratio of male to female cells is as 1 is to 3.4.

It has also been shown that gametocytes are present early in course of tertian malaria initiated by mosquitoes. This was demonstrated by the successful infection of mosquitoes on two different cases of malaria on the fourth day following the onset of the infections. The practical value of this finding is to emphasize the necessity for screening all cases of tertian malaria from the very beginning of the disease.

Incidental to the use of Anopheles punctipennis in this work, the following summary may be made:

Tertian malaria was transmitted by Anopheles punctipennis in 6 of 9 attempts.

The incubation period in 6 cases of tertian malaria initiated by mosquitoes varied from fourteen to thirty-one days.

Anopheles punctipennis is an efficient experimental vector of Plasmodium vivax.

¹ This research was aided by a grant from the Committee on Scientific Research of the American Medical Association.