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Critical Tests of Hookworm Remedies on Man

The efficiency of carbon tetrachloride and of the more recently introduced remedy, tetrachlorethylene, against hookworms has been systematically demonstrated on dogs by Dr. M. C. Hall of the Bureau of Animal Industry. The efficacy tests were performed by administering the drugs to animals and counting all the worms passed after careful screening of the stools. After the treatment the test animals were killed and all worms remaining were recovered and counted. A comparison of the number of worms removed by treatment with the number of worms recovered post mortem establishes the degree of efficacy of the anthelmintic.

The present paper gives a record of data as regards the efficacy of anthelmintics in man similar to those obtained by Hall and his coworkers on dogs. The drugs tested against hookworms were carbon tetrachloride, oil of chenopodium and thymol. The possible relation of the specific drug to the death of the patients involved will not be dealt with in this paper.

Received July 30, 1926.