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The Effect of Magnesium Sulphate, Simultaneously Administered, on the Efficacy and Safety of Carbon Tetrachlorid for the Removal of Hookworms¹

The experiments on dogs reported by us in this paper indicate that the efficacy of carbon tetrachlorid is not impaired by the simultaneous administration of magnesium sulphate. The work of Macht and Finesilver indicates that this simultaneous administration will result in decreased absorption of carbon tetrachlorid and thereby increase the safety factor. This method of administration of carbon tetrachlorid deserves test as a possible method of increasing the safety of carbon tetrachlorid and avoiding the occasional bad results obtained with this highly effective anthelmintic.

¹ Read by title at the nineteenth annual meeting of the American Society of Tropical Medicine, San Francisco, Cal., June 25 and 26, 1923.