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Para-Specific Action of Bothropic and Crotalic Antivenins¹

The neutralization of Agkistrodon, Bitis, Naja, Sepedon and Vipera venomas by anti-bothropic and anti-crotalic sera was examined quantitatively. It was found that these antivenins exert a slight degree of para-specific action on venoms of the genus Vipera only. This neutralization is, however, much inferior to that by specific antivenins, so that the once recommended use of South American sera in European snake poisoning is not justified. Some problems of antivenin titration are discussed.

¹ Carried out under Government of the State of São Paulo (Public Health) Contract Reg. no. TC 4045 and presented before the Society of Experimental Medicine at São Paulo, S.P., December 9, 1950.

² From the Instituto Butantan, São Paulo, S.P., Brazil.