AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., s1-31(6), 1951, pp. 698-702
Copyright © 1951 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Payne, E. H.
Right arrow Articles by Wille, W. S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Payne, E. H.
Right arrow Articles by Wille, W. S.

Intravenous Amodiaquin (Camoquin1) in Naturally Acquired and Induced Malaria

Eugene H. Payne2, Victor M. Villarejos3, E. A. Sharp4, J. W. Reinertson5 AND Warren S. Wille6

Amodiaquin (Camoquin Hydrochloride), a synthetic antimalarial, has been studied by different investigators, (1, 2, 3, 4, 5, 6, 7) and its high effectiveness by oral administration against the different species of pathogenic plasmodia has been proved. All of them confirm the rapidity with which the parasites disappear from the circulating blood and the resulting remission of the acute symptoms of the disease.

This drug is the dihydrochloride dihydrate of 4-(3'-diethyl-aminomethyl-4'-hydroxyanilino)-7-chloroquinoline and is soluble in water in a concentration of 5% at room temperature resulting in a clear yellow solution. Oral administration when possible, is preferable to other forms of administration in all antimalarial treatment. However, it is necessary to remember that an effective and dependable antimalarial for parenteral administration having rapid action is a valuable weapon for the treatment of the algid state, comatose patients, those who are vomiting or who have diarrhea which prevents good absorption of the medication from the intestine.


1 Camoquin is Parke, Davis and Company's registered trademark for amodiaquin.


2 Department of Clinical Investigation, Parke, Davis and Company, Detroit, Michigan.


3 Professor of Tropical Pathology, University of San Andrés, La Paz, Bolivia.


4 Director, Department of Clinical Investigation, Parke, Davis and Company, Detroit, Michigan.


5 Assistant Paristiologist, Research Laboratory, Parke, Davis and Company, Detroit, Michigan.


6 Ypsilanti State Hospital, Ypsilanti, Michigan.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1951 by the American Society of Tropical Medicine and Hygiene.