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A Comparison of Aureomycin and Carbarsone in the Treatment of Intestinal Amebiasis^1,2,

Of fifteen patients treated for intestinal amebiasis with 250 mgm. of aureomycin twice daily for 10 days there was a 53 per cent apparent cure rate (6 negative post-treatment purged stool specimens). Of fifteen treated with 250 mgm. of aureomycin thrice daily for 10 days, there was an 80 per cent apparent cure rate. By way of comparison, among the 40 individuals who took a combination of carbarsone (250 mgm. three times a day for 10 days) and sulfadiazine (3.0 Gm. priming dose and 1.0 Gm. four times a day), there was a 52 per cent apparent cure rate. Side effects of the drugs were negligible.

It is evident that aureomycin in the higher of the two dosages used is an effective amebicidal agent, and it is likely that with still higher dosages the effect would be more noteworthy.

¹ From the Medical Department of the Tela Railroad Co., United Fruit Co., La Lima, Honduras.

² The Aureomycin was supplied by the Lederle Laboratories Division of the American Cyanamid Company.

³ With the Technical Assistance of Quintin Gonzalo Máximo.