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Chloromycetin¹ in Experimental Trypanosoma Equiperdum Infection in Rats^,2

Chloromycetin was inactive against filariasis in the cotton rat (1), was mildly active in Borrelia novyi infection in mice (2), and had a curative effect in experimental syphilis in the rabbit (3). The chemotherapeutic action against trypanosomiasis is shown herewith.

Albino rats, weighing 108 to 140 grams, were inoculated intraperitoneally with a suspension of Typanosoma equiperdum in physiological saline. The infected animals showed a mean parasitemia of 39 trypanosomes per 1000 red blood cells in forty-eight hours. At this time, Chloromycetin was administered to groups of five animals each in single intravenous doses of 20, 40, 60, 80, or 100 mgs./kg., of 1.0 per cent concentration in 60 per cent propylene glycol-water solution. In the subsequent twenty-four hours a number of animals were dead or dying. Those living showed increased trypanosome counts in blood while the dead animals showed positive liver smear preparations. All animals were dead forty-eight hours after treatment (Table 1).

¹ Parke, Davis and Company registered trade-mark for chloramphenicol.

² Research Laboratories, Parke, Davis and Company, Joseph Campau Ave. at the River, Detroit 32, Michigan.