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Aureomycin in the Treatment of Yaws¹

Aureomycin² has been shown to be effective in the treatment of infections caused by certain bacteria, viruses, rickettsiae and spirochaetes. Among the infections due to spirochaetes, it has been investigated clinically in the treatment of syphilis (1) and experimentally in the treatment of relapsing fever and leptospirosis icterohaemorrhagica (2). There have been no reports concerning the use of aureomycin in the treatment of yaws.

In January 1950, at the Hôpital Général, Port-au-Prince, Haiti, we commenced a clinical study to determine the effectiveness of aureomycin as a therapeutic agent in yaws. Thirty patients, all of whom were West Indians, were selected for this investigation with the aim of obtaining representative examples of each stage of yaws for treatment with aureomycin. Eight patients were female and twenty-two were male. Their ages ranged from 7 through 61 years. Three had primary lesions only; eight had both primary and secondary lesions; one had a primary lesion, secondary lesions and plantar lesions;

¹ The Institute of Inter-American Affairs, Division of Health and Sanitation, Port-au-Prince, Haiti.

² The aureomycin hydrochloride used in this study was supplied through the courtesy of Dr. R. W. Linton of the Lederle Laboratories, Division of American Cynamide Company.