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A Heretofore Unreported Agglutinable Human Blood Factor and Its Possible Relationship to Blackwater Fever^1,2,3,

It appears that a new human agglutinable blood factor has been demonstrated by the use of chimpanzee-immune serum developed in rabbits.

The presence in 97 per cent of all healthy white group O individuals and 97.4 per cent of all healthy group O negroes studied strongly suggested that it is not associated with the AB, MN, Rh-Hr, or P systems.

While we are not certain as to the usefulness of this factor it appears from previous work that its absence is intimately associated with the etiology of blackwater fever.

It is possible that this factor may explain the unaccounted for reactions following the transfusion of compatible bloods of both AB group and Rh type.

¹ This is Paper No. 5 from the Medical Research Unit of the University of Miami, and the Veterans Administration Hospital, Coral Gables, Florida.

² To the Anthropoid Ape Research Foundation of Dania, Florida, and to its personnel, especially David R. Denis and Billy G. Mann, we are greatly indebted for all chimpanzee blood used in these studies. Their cooperation at all times made this work possible.

To Louise D. Scott, my acknowledgement for the technical assistance rendered throughout much of this investigation.

To Dr. Alfred Blumberg of the Veterans Administration Hospital and Dr. Murray Sanders of the Medical Research Unit of the University of Miami, I am indebted for their excellent cooperation.

Finally, to Dr. Philip Levine my appreciation for supplying the anti-Cellano serum.

³ Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the author are the result of his own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

⁴ Department of Bacteriology, Division of Tropical Disease Research, University of Miami, Medical Research Unit, Coral Gables 34, Florida.