AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med., s1-30(3), 1950, pp. 371-376
Copyright © 1950 by American Journal of Tropical Medicine

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The Rate of Disappearance of Leishmania Donovani from the Spleen of the Infected Golden Hamster Following a Single Injection of a Pentavalent Antimonial1

Frederick G. Germuth, Jr., M.D., Harry Eagle, M.D. AND Vance Oyama

1. Following a single intramuscular injection of pentavalent antimonials, there was a progressive decrease in the number of viable L. donovani in the spleen of infected hamsters, the decrease continuing as long as 16 to 32 days after injection.
2. Possible explanations for this prolonged action, and its implications for the treatment of leishmaniasis in man, have been discussed.


1 From Section on Experimental Therapeutics, Laboratory of Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland.






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Copyright © 1950 by the American Society of Tropical Medicine and Hygiene.