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Discussion¹

I have been asked to discuss the chemotherapy of amebiasis, a subject which I must necessarily approach from the viewpoint of a laboratory worker who is concerned with the search for more effective therapeutic amebacidal agents. Discussion of the chemotherapy of hepatic amebiasis might seem superfluous after Dr. Conan's presentation of the excellent results obtained in the treatment of hepatic amebiasis with chloroquine, but there are certain aspects of the disease which deserve further consideration or emphasis. Since the development, evaluation, and successful clinical application of amebacidal drugs will be affected by factors which are inherent in the pathogenesis of the disease and in the various properties of a drug, I wish to direct your attention particularly to those aspects of pathogenesis and pharmacological behavior which are determining factors in successful chemotherapy.

The etiology and pathology of amebic lesions appear to be clearly defined and uncomplicated.

¹ See footnote² Introduction to Panel.

² Sterling-Winthrop Research Institute, Rensselaer, N. Y.