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Camoquin Treatment of Malaria: a Preliminary Report¹

1. Camoquin, a 4-aminoquinoline compound, was administered in a single dose of 10 mgm/kg. to 30 patients with vivax malaria and to 20 with falciparum malaria.

2. Among both the vivax and the falciparum patients, all temperatures were normal within 48 hours of treatment; the average temperature was normal by 32 hours after treatment.

3. Parasitemia disappeared quickly, the time averaging 37 hours for vivax cases, 30 hours for falciparum cases.

4. Only one vivax clinical relapse occurred, although patients were under observation for periods of 6 to 16 months.

5. Camoquin is a relatively non-toxic drug.

6. Camoquin deserves more widespread use in malarious areas throughout the world, and should be particularly valuable in rural locations and/or when hospitalization of the patient is not feasible.

¹ From the Medical Service of Gorgas Hospital, Ancon, Panama Canal Zone.

² Gratitude is expressed to Parke, Davis & Co. for supply of Camoquin used in this study. The author also expresses appreciation to Dr. Gilbert M. Stevenson, Chief of the Medical Service of Gorgas Hospital, Panama Canal Zone, for permission to carry out the study on the wards of that hospital and for advice and counsel.

³ Box 128, Ross, California.