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Indirect in Vitro Action of Antibiotics in Comparison with Activity of Accepted Amebacides¹

1. The method designed to test whether or not an apparently amebacidal action is exerted indirectly through inhibition of growth of associated bacteria has been applied to nine antibiotics. It was found that all exhibited some degree of indirect action in vitro.

2. The method has also been used to retest seven accepted amebacides. The slight bacteriostasis observed in two of them (carbarsone oxide and vioform) was insufficient to influence the test. No bacteriostasis was otherwise observed.

3. Indirect action through bacteriostasis has been correlated with oxidation of the culture medium.

4. Direct amebacidal action cannot be determined in the presence of an agent having bacteriostatic activity by the method presented.

¹ From the Division of Pharmacology and Experimental Therapeutics, University of California Medical School, San Francisco, California. This investigation was supported by grants from the National Institutes of Health and Abbott Laboratories. A portion of this report was presented before the American Society for Pharmacology and Experimental Therapeutics at the meeting of the Federation of American Societies for Experimental Biology, Detroit, Michigan, April 22, 1949.

² Present address: Department of Tropical Medicine and Public Health, Tulane University of Louisiana, School of Medicine, New Orleans, Louisiana.