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The Hepatic Lesions of Experimental Yellow Fever

When Noguchi, in 1919 (1), published his first pathological findings in experimental yellow fever, he spoke of yellow livers (in which fatty degeneration may be presumed to exist), but in treating of the pathological histology of such organs he described only tumefaction, vacuolization,¹ and necrosis of the cells, the frequent presence of karyokinetic nuclear figures (this phenomenon, which also interested Martin and Pettit (2) in their study of the livers of guinea pigs dying of infection with Leptospira icterohaemorrhagiae, is demonstrable also in human yellow fever (3)), the existence of irregularly distributed hemorrhagic foci and periportal lymphocytic infiltration, and finally the presence of Leptospira icteroides.

Villamil Mendoza, who infected (in Mérida) four guinea pigs and two dogs with the blood of a guinea pig which had in turn been infected by the injection of blood from human yellow fever, refers, in speaking of the liver lesions in both dogs, to the existence of a "very marked fatty degeneration," a liver like butter (4).

Received October 10, 1922.
¹ As is well known, if the special histochemical technique for the staining of fat is not employed, the cells which are attacked by a distrophic steatosis may appear as simply vacuolated.