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Treatment of Loa Loa Infections with Hetrazan¹

The successful results reported in the treatment of Wuchereria bancrofti infections with 1-diethylcarbamyl-4-methyl-piperazine ("hetrazan")² (1) prompted us to try this new drug in case of Loa loa infection. To date, we have treated five cases. As is frequently the case in Loa loa infections, microfilariae could not be found in the venous blood. However, the clinical picture is distinctive and a diagnosis can be established without the finding of microfilariae. Good results have been obtained in all five cases. All were completely relieved of symptoms and the only recurrence was in one case in which the chief manifestation was an unusual one, diffuse pruritis.

THE CASES We have tabulated the important clinical findings in the five cases (Table 1). All were adults; there were four men and one woman. Three were missionaries in the French Cameroons, one a merchant from the same area, and the fifth a physician who had worked for several years in Angola.

¹ From the Bureaus of Laboratories and Preventable Diseases, Health Department, City of New York.

² The hetrazan used in these studies was supplied by the Lederle Laboratories Division of the American Cyanamid Company, either directly or through the agency of Dr. Harold W. Brown.