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The Inflammatory Reaction to Toxoplasma in the Omentum and Peritoneal Fluid of the Mouse^*

This paper is the second in a series of cytologic studies on Toxoplasma. The first dealt with the cytologic structure of the parasite as found in the ascitic fluid of the infected mouse and as revealed by the Feulgen reaction (1). An investigation of the inflammatory reaction to Toxoplasma, simultaneously, in the omentum and in the peritoneal fluid follows logically because: 1. The close juxtaposition of this tissue and the fluid obligates their concomitant consideration; 2. Certain artifacts of common occurrence with other tissues may be avoided with the omentum; (a) Sectioning for microscopic examination is unnecessary; (b) The blood vessels and nerves may be observed in situ in relatively lengthy unmutilated portions; (c) The inoculation is without trauma to the omentum so that infection results from an unmodified selective migration of the parasite; and 3. The varied cellular structure of the omentum permits the assumption of a similar pattern of invasion for other tissues in the mouse.

^* This work supported in part by grants from the U. S. Public Health Service and the U. S. Navy Office of Naval Research.

¹ Department of Preventive Medicine and Public Health, University of Texas Medical Branch, Galveston, Texas.