AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med., s1-29(2), 1949, pp. 181-184
Copyright © 1949 by American Journal of Tropical Medicine

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The Active Form of Tryparsamide, TPB, in the Treatment of Human Trypanosomiasis1,2,

Ernst A. H. Friedheim, M.D., Ph.D.

TPB represents the "active form", i.e. the arsenoxide of tryparsamide in a stabilized and detoxified form, combining high trypanocidal activity towards the trypanosomes in blood and lymph and CSF, with the propensity to clear up readily the trypanosome meningo-encephalitis.

TPB is without effect on tryparsamide resistant trypanosomes.


1 From the Laboratory of Ernst A. H. Friedheim, 333 West 52nd St., New York 19, N. Y.


2 In collaboration with the Sleeping Sickness Service of French West Africa.







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Copyright © 1949 by the American Society of Tropical Medicine and Hygiene.