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The Action of Antimalarial Drugs in Mosquitoes Infected with Plasmodium Falciparum¹

In a previous report (1) evidence was presented to show that there is a definite relation between drug activity in the invertebrate host infected with Plasmodium gallinaceum, and drug activity in the sporozoite infected vertebrate host. This conclusion has been predicated on the fact that those drugs which have a prophylactic effect on sporozoite induced infections of P. gallinaceum in the vertebrate host have a similar prophylactic effect in the mosquito in that they permanently arrest the development of the oocysts so that sporozoites are never produced, whereas, the ordinary suppressive drugs, which have no prophylactic activity in the vertebrate host, are similarly ineffective in the mosquito since they have no discernible effect on the development of oocysts and the production of sporozoites.

For the purposes of this study a prophylactic drug in the vertebrate host is defined as one, which, when administered for a specific interval, permanently interrupts the pre-erythrocytic development of the parasite and prevents the formation of the erythrocytic forms, and, correspondingly, in the invertebrate host, a prophylactic drug is defined as one that is effective against the pre-sporozoite stages of the parasite and prevents the formation of sporozoites.

¹ The authors wish to express their appreciation to Dr. V. H. Haas and Dr. M. D. Young for making available the facilities of the Malaria Research Laboratory of the U. S. Public Health Service at Columbia, South Carolina, and to Dr. R. D. Burgess for his unstinting help.

² Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland.