HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schubert, M. Articles by Schreiber, F. G. Search for Related Content PubMed Articles by Schubert, M. Articles by Schreiber, F. G.

Comparison of Several Antimonials in the Treatment of Experimental Schistosomiasis Mansoni in Mice^1,2,

No data at all has yet been published on therapeutic indices of any drugs in any form of schistosomiasis. Recent reports from this Laboratory (1, 2) have described methods for testing the effects of drugs on experimental schistosomiasis mansoni in mice. The drug testing was of a rough screening nature and only a very crude classification of drugs into four groups was provisionally attempted: 1. Drugs that cleared most of the mice of worms and left an average of not over one worm per mouse. 2. Drugs that left an average of between one and five worms per mouse, caused a shift of most of the worms to the liver and reduced the proportion of worms paired to values below fifty per cent. 3. Drugs that during treatment caused a shift of most of the worms to the liver and a breakup of most worm pairs followed after the end of treatment by a reversal of these changes, but that never caused the average number of worms per mouse to fall below five.

¹ From the Department of Therapeutics, New York University College of Medicine.

² The work described in this paper was supported by a research grant from the Division of Research Grants and Fellowships of the National Institute of Health, U. S. Public Health Service.