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Experimental Histoplasmosis: Portal of Entry of the Fungus^1,2,

In an attempt to determine the portal of entry of Histoplasma capsulatum into experimental animals, mice and guinea pigs were inoculated with this fungus in its yeast-like phase. Routes of experimental inoculation were oral and intranasal, with intravenous and intraperitoneal injection being used as controls. Criteria of infection in the animals were positive cultures from the tissues and typical gross pathology at autopsy.

In the feeding experiments 30 mice and 12 guinea pigs were used. Organisms morphologically identical with Histoplasma capsulatum were recovered in cultures from 21 mice and 9 guinea pigs.

Twelve guinea pigs were inoculated intranasally, and yeastlike fungi were recovered from 9 animals.

¹ Read at the annual meeting of the Society of American Bacteriologists, Minneapolis, May 12, 1948.

² This is a portion of a thesis presented to the Graduate Faculty of the University of Minnesota in partial fulfillment of the requirements for the Ph.D. degree. The author wishes to acknowledge with appreciation the counsel and guidance during the progress of this research of the late Dr. W. P. Larson and Dr. C. E. Skinner of the Department of Bacteriology and Immunology of the University of Minnesota Medical School.

³ Department of Pathology and Bacteriology, University of Nebraska College of Medicine, Omaha.

⁴ Present address: Dept. Bacteriology, School of Medicine, Univ. Rochester, Rochester 7, N. Y.