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Cross-Immune Reactions between Panamanian Strains of Q Fever and Endemic Typhus

Guinea-pigs recovered from an infection with the SM strain of murine typhus showed a partial immunity against the Panamanian JD strain of Q fever as indicated by prolongation of the incubation period and shortening of the febrile period.

In reverse cross-immunity experiments, guinea-pigs immune to the JD strain of Q fever showed a variable febrile reaction and consistent suppression or modification of the testicular reaction on inoculation with murine typhus rickettsia.

Complement-fixation tests, employing immune guinea-pig serums and yolk sac antigens, showed no significant cross-reactions.

¹ Department of Public Health and Gorgas Memorial Laboratory, Panama, R. de P.