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The Use of a Phenyl Arsenoxide in the Treatment of Wuchereria Bancrofti Infection¹

It has been shown (Otto and Maren, 1947) that the substituted phenyl arsenoxides as a group have a markedly lethal action in vitro against the microfilaria of both Dirofilaria immitis and Litomosoides carinii. In well tolerated doses several of them will regularly kill the adults of both these filariids in their respective hosts, the dog and the cotton rat. Of these arsenamide (p-[bis-(carboxymethyl-mercapto)-arsino]-benzamide; T.D.C. #970) kills all the adult worms of D. immitis in daily intravenous doses of 0.23 mgm. As. per kilogram for two weeks. However, such doses do not effect any immediate reduction in the microfilaria count.

Arsenamide contains 20 per cent arsenic and is readily soluble as its sodium salt (Maren, 1946). We have used it as a 2 per cent solution buffered at approximately pH 7.0 and have found that it is stable when stored in amber vials.

¹ From the Department of Parasitology of the School of Hygiene and Public Health of the Johns Hopkins University, Baltimore, Md., the Department of Parasitology of the School of Public Health of the Medical Faculty of Columbia University, and the Department of Health, Christiansted, Saint Croix, the Virgin Islands.

This work was supported in part by a contract recommended by the Committee on Medical Research initially between the Office of Scientific Research and Development and the Johns Hopkins University and continued between the Office of the Surgeon General of the U. S. Army and the same university and in part by a grant from the John and Mary R. Markle Foundation to Columbia University.