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Chemotherapy of Lymphogranuloma Venereum¹

Of the various chemotherapeutic substances stated to have activity against the agent of lymphogranuloma venereum only the sulfonamides have proven themselves valuable clinically. Experimental investigation in mice has confirmed this but has shown that although the acute symptoms are relieved by the sulfonamides the tissues in the majority of cases are not sterilized even with high blood levels of drug. Some carrier strains recovered from treated mice have shown a degree of increased resistance to sulfonamides and at least one strain with similar increased resistance has been isolated from a human case. Both experimentally and clinically penicillin has shown a definite activity in this infection but one that is disappointingly low.

¹ Given before the American Society of Tropical Medicine, December 3, 1947, Atlanta, Georgia.