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Am. J. Trop. Med., s1-28(2), 1948, pp. 295-297
Copyright © 1948 by American Journal of Tropical Medicine

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The In Vitro Effect of Atabrine on Cryptococcus Neoformans

David Dean Brockman, M.D.1

Atabrine is fungicidal in vitro at concentrations of 25 to 50 mgm. per cent and fungistatic at 3 to 25 mgm. per cent for C. neoformans. Toxic reactions are obtained with much lower plasma or tissue concentrations. Atabrine is, therefore, of little therapeutic value in cryptococcus infections.


1 From the Department of Pathology, Duke University School of Medicine, Durham, North Carolina.






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Copyright © 1948 by the American Society of Tropical Medicine and Hygiene.