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Am. J. Trop. Med., s1-28(1), 1948, pp. 87-100
Copyright © 1948 by American Journal of Tropical Medicine

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Studies on Cyclic Passage of Yellow Fever Virus in South American Mammals and Mosquitoes1

IV. Marsupials (Metachirus Nudicaudatus and Marmosa) in Combination with Aedes Aegypti as Vector

Mary B. Waddell AND R. M. Taylor
From the Laboratory of the Yellow Fever Research Service, Rio de Janeiro, Brazil

Cyclic passages of jungle yellow fever virus strains were successfully made by using Metachirus nudicaudatus and Marmosa cinerea as animal hosts and Aedes aegypti as the insect vector.

One jungle yellow fever strain which was isolated from a marmoset captured in a region where the disease is endemic was found to be better adapted to passage through metachirus than was a strain obtained from a human infection during a transient outbreak of jungle yellow fever. After repeated passage, by means of mosquitoes, through marmosets and metachirus, this latter strain apparently became more suited to passage through metachirus and was thereafter maintained in cyclic passage through metachirus without difficulty.

While these marsupials are easily infected with yellow fever virus through the bite of the infected mosquito vector, they do not so readily or so consistently infect normal mosquitoes as do two species of marmosets which were previously studied.

The epidemiological implications of these observations are discussed.


1 The work on which these observations are based was done under the auspices of the Serviço de Estudos e Pesquisas sôbre a Febre Amarela (Yellow Fever Research Service), which is maintained jointly by the Ministry of Education and Health of Brasil and the International Health Division of The Rockefeller Foundation.






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Copyright © 1948 by the American Society of Tropical Medicine and Hygiene.