HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Young, M. D. Articles by Stubbs, T. H. Search for Related Content PubMed Articles by Young, M. D. Articles by Stubbs, T. H.

Some Characteristics of Foreign Vivax Malaria Induced in Neurosyphilitic Patients^1,2,

1. White neurosyphilitic patients were infected with foreign Plasmodium vivax malaria, both by blood inoculation and by mosquito bite. Infections resulting from mosquito transmission showed the averaged prepatent period to be 12.8 days and the average incubation period to be 14.2 days. These periods were significantly shorter for the Mediterranean strains than for strains from the Pacific.

2. In the mosquito transmitted infections, the first maximum fever usually preceded the maximum parasitemia by several days. The average of the first maximum fever was 106.0° F. The maximum parasitemia averaged 13,900 parasites per cmm.

3. In the blood transmitted infections, the first maximum fevers and the maximum parasitemias usually occurred at about the same time. The maximum parasitemias were higher than in mosquito induced infections.

4. The tertian type paroxysms showed an average periodicity of 44.5 hours, ranging from 43.6 to 45.1 hours. None showed a 48-hour periodicity.

5. Chills accompanied the fevers in 73.2 per cent of the cases. Chills were less frequently present with the first 5 fevers than with the later fevers.

6. The types of fever at onset of mosquito induced infections were: quotidian, 50 per cent; remittent, 42 per cent; and tertian, 8 per cent. These types were often succeeded by a different type.

7. Sodium bismuth thioglycollate was reliable in changing remittent and quotidian paroxysms to tertian occurrence.

8. Usually, the primary infections produced over 10 paroxysms.

9. Little or no heterologous immunity was demonstrated between 5 foreign strains and the St. Elizabeth strain of P. vivax.

10. The foreign malarias appear to be satisfactory as a therapeutic agent to treat white neurosyphilitic patients. This was not true of Negro patients.

Received March 26, 1947.
¹ This is the sixth in a series of reports on imported malarias. The complete title of this report reads, "Studies on Imported Malarias. 6. Some Characteristics of Foreign vivax Malarias Induced in Neurosyphilitic Patients".

² Contribution from the Imported Malaria Studies program of the Office of Malaria Investigations, National Institute of Health, and the Office of Malaria Control in War Areas, United States Public Health Service, Columbia, S. C.

The Harmon General Hospital and the South Carolina State Hospital furnished laboratory space and made possible the securing of the information upon the induced infections. To the staffs of these hospitals we express our appreciation as well as to the Office of the Surgeon General, United States Army, whose active interest made the program possible.

³ Now Assistant Dean, Emory University Medical School.