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Experimental Chemotherapy of Amebiasis¹

(1) The pathogenesis of amebiasis is discussed.

(2) Comparative amebacidal tests in vitro and in vivo have been made, utilizing improved appraisal technics.

(3) The development of an essentially synthetic medium may lead to a more rational approach to the chemotherapy of this disease.

(4) The mechanisms of anti-amebic action have been demonstrated for two of the various chemical types available.

(5) Three trivalent arsenicals (two containing sulfur) have proved of value in trials in macaques, and one has been effective in initial trials in man.

¹ With the technical assistance of Alvin S. Hambly Jr., Bertha Gardiner and Elsa Zitcer.

The work described in this report was done under a contract recommended by the Committee of Medical Research, between the Office of Scientific Research and Development, the Surgeon General's Office, United States Army Service Forces, and the University of California.