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Am. J. Trop. Med., s1-26(3), 1946, pp. 311-318
Copyright © 1946 by American Journal of Tropical Medicine

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Preliminary Report on the Evaluation of Penicillin in the Treatment of Yaws*

James H. Dwindelle1, Charles R. Rein2, Thomas H. Sternberg3 AND Albert J. Sheldon4

In summary it may be said that penicillin holds definite promise as a therapeutic agent in yaws. Its use in doses of 1,200,000 O. U. in adults and proportionate doses for children given over periods of four, two and one days respectively resulted in rapid clinical cures. The serologic response was not as striking as the clinical, but until more follow-up figures are obtained a full evaluation is n ot possible. The oil-beeswax preparation of penicillin made it possible to treat patients on an ambulatory basis over one and two days with the same dose of penicillin given in aqueous solution to hospitalized patients over four days. The immediate clinical and serologic results obtained with pencillin in oil with beeswax appeared to be as good as those of the aqueous solution. The development of a successful one-day treatment schedule would be of great practical value in a country such as Haiti where large numbers of patients must be treated on an ambulatory basis in rural clinics. A report on 12 months follow-up observations will be made at a later date.


* Cooperative research project of the Division of Health and Sanitation, Office of Inter-American Affairs; Preventive Medicine Service, Office of the Surgeon General, U. S. Army; Divisions of Serology and Parasitology, Army Medical Center; and the Government of the Republic of Haiti. The Authors wish to acknowledge the aid and cooperation of Brigadier General James S. Simmons, USA, Chief, Preventive Medicine Service, Office of the Surgeon General; Brigadier General George R. Callender, USA, Director, Army Medical School, Army Medical Center; Colonel John D. Yeagley, MC, AUS, Director, Division of Health and Sanitation, Office of Inter-American Affairs; Dr. J. E. Moore, Johns Hopkins Hospital; Drs. Roger Saint-Victor and Edie Lemoin, American Sanitary Mission (representative of the Office of Inter-American Affairs), Haiti; Dr. Edouard A. Petrus and Mr. Georges Milfort, General Hospital Laboratory, Haiti; Major Arthur C. Allen, MC, AUS, Army Institute of Pathology; and Felix V. Jean-Louis, American Sanitary Mission Haiti.

Read at the annual Meeting of the American Society of Tropical Medicine at Cincinnati, Ohio, November 14, 1945.


1 Lt. Col. M.C., A.U.S., Chief of Field Party, American Sanitary Mission (representative of the Office of Inter-American Affairs), Port-au-Prince, Haiti.


2 Lt. Col. M.C., A.U.S., Formerly Chief, Division of Serology, Army Medical School, Army Medical Center, Washington, D. C.


3 Lt. Col. M.C., A.U.S., Chief, Venereal Disease Control Division, Preventive Medicine Service, Office of the Surgeon General, U. S. Army, Washington, D. C.


4 Maj. M.C., A.U.S., Chief, Helminthology Section, Division of Parasitology, Army Medical School, Army Medical Center, Washington, D. C.






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Copyright © 1946 by the American Society of Tropical Medicine and Hygiene.